Quinone reductase

Foster, C. E., Bianchet, M. A., Talalay, P., Faig, M. Amzel, L. M. (2000). Structures of mammalian cytosolic quinone reductases. Free Radic. Biol. Med. 29, 241-5. 

The antioxidant system in humans is a complex network composed by several enzymatic and nonenzymatic antioxidants. In addition to being an antioxidant, lycopene also exerts indirect antioxidant properties by inducing the production of cellular enzymes such as superoxide dismutase, glutathione S-transferase, and quinone reductase that also protect cells from reactive oxygen species and other electrophilic molecules (Goo and others 2007). 

Liu G, Zhou J, Wang J (2009) Acceleration of azo dye decolorization by using quinone reductase activity of azoreductase and quinone redox mediator. Bioresour Technol 100 2791-2795... 

From the biological point of view, the effect of anaerobiosis has been characterized in purely anaerobic, facultative anaerobic, and aerobic bacteria, in yeasts, and in tissues from higher organisms [6-12], From these studies it can be deduced that almost every azo compound can be biologically reduced under anaerobic conditions [4]. Reduced flavins are produced by cytosol flavin-dependent reductases [6, 13], while quinone reductase activity located in the plasma membrane [14] and extracellular azo reductase activities [9, 15] were also observed. 

Ross D. Quinone reductases multitasking in the metabolic world. Drug Metab Rev 2004 36(3-4) 639-654. 

Vella F, Ferry G, Delagrange P, et al. NRH quinone reductase 2 an enzyme of surprises and mysteries. Biochem Pharmacol 2005 71(1-2) 1-12. 

This enzyme [EC 1.6.99.2] (also known as NAD(P)H quinone reductase, DT diaphorase, quinone reductase, azoreductase, phylloquinone reductase, and menadione reductase) catalyzes the reaction of NAD(P)H with an acceptor to produce NAD(P) and the reduced acceptor. This FAD-dependent enzyme is inhibited by dicoumarol. 

Clbacron blue dependent enzymes Quinone reductases... 

Quinone reductase induction. Acetonitrile extract of the dried root, in cell culture at a concentration of 7.9 mg/g, was active on Hematoma-Mouse-lClC7. The sample was assayed for the induction of detoxifying enzymes that may have anticarcinogenic activity . 

Carcache-Blanco, E.J. et al.. Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase, J. Nat. Prod., 66, 1197, 2003. 

Su, B.-N. et al. Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay, Phytochemistry, 63, 335, 2003. 

Chang, L.C. et al.. Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase. Journal of Natural Products, 60, 869, 1997. 

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