Syngeneic bone marrow cells

In a typical experiment of this type, Cudkowicz et al. (1970) injected (i.v.) graded numbers of syngeneic bone marrow cells (ranging from O.37 to 6x10 ... 

Identification of this gene rearrangement is the sine qua non for the diagnosis of CML, and its presence in the hematopoietic cells of virtually all patients with CML made it an ideal target for the development of therapeutic agents. Proof that BCR-ABL 1 was crucial for the development of CML was shown when the hybrid gene was transfected into bone marrow cells of mice which were subsequently transplanted into an irradiated syngeneic recipient and shown to lead to the development of a CML-like syndrome (5). 

Syngeneic Transplant The person donating the bone marrow or stem cell is an identical twin. 

Between 1949 and 1954, Jacobson, Lorenz, Barnes and Loutit made important experiments in mice showing that cells from the spleen or the bone marrow protected from death caused by radiation. Of note, a different evolution was observed after syngeneic and allogeneic transplantation, since mice in the latter group usually died due to complications defined as secondary disease . This experience anticipated the most relevant problem after this type of transplantation, graft-versus-host disease (GVHD). 

Figure 4 Enhanced B-cell proliferation by coculture of AdCD40L-modified DCs and syngeneic B cells. EX2s purified from bone marrow were transduced with AdCD40L or AdNull and then cocultured with nonspecific B cells. Coculture of irradiated AdCD40L transduced DCs (AdCD40L) with B cells resulted in the proliferation of the B cells, whereas AdNull-modified DCs (AdNull) or nMve DCs (Naive) induced no B-cell proliferation.

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