Osteogenic differentiation bone marrow-derived stem cells

Mesenchymal stem cells are a valuable therapeutic tool in tissue engineering because they proliferate and differentiate into distinct cellular phenotypes, such as osteoblasts, chondrocytes, adipocytes, and muscle cells. Mesenchymal stem cells have been initially identified in bone marrow as nonhe-matopoietic stem cells, called bone marrow-derived stan cells. Their osteogenic differentiation potential was described by Maniatopoulos et al. (1988). The adipose tissue, often removed during... 

Stem cells isolated from human exfoliated deciduous teeth (SHED) have been identified as a novel population of MSC family. SHED have the same capacity as bone marrow-derived MSCs to differentiate into multiple cell types, including osteoblasts and odontoblasts, and to generate bone or dentin-pulp complex tissue (Miiua et al., 2003 Cordeiro et al., 2008 Yamada et al., 2010). However, osteogenic/odontogenic differentiation of SHED and bone marrow-derived MSCs is regulated by different mechanisms, and SHED can have a stronger tendency to be induced into odontoblasts than bone marrow-derived MSCs (Kara et al., 2011). Most importantly, SHED show very strong proliferative abilities and can be obtained from deciduous teeth without any ethical concern, which may provide a useful cell source as an alternative to bone marrow-derived MSCs for mineralized tissue formation. 

Hanada, K., Dennis, J.E., and Caplan, A.l. Stimulatory effects of basic fibroblast growth factor and bone morphogenetic protein-2 on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. /. Bone Miner. Res. 12 1606-1614,1997. 

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