Biomimetic polymers

Biomimetic polymers in pharmaceutical and biomedical sciences. Eitropean Journal of Pharmaceutics and Biopharmaceutics, Vol. 58, 2, (September 2004), pp. (385-407), ISSN 0939-6411... 

Rather than using the protein molecule as a whole, the imprinting of selected protein epitopes may present a more practical approach. Imprints of such patches may then act as receptors for these parts of the protein. It could be shown that an MIP imprinted with a tetrapeptide was able to recognize not only the template but also a protein bearing the same 3-amino acid terminus as the peptide template [129]. If this approach proves to be successful in other cases as well, MI-based recognition will no longer be limited to small molecules. The result will be even more antibody like biomimetic polymers. 

Guan Z. Supramolecular design in biopolymers and biomimetic polymers for advanced mechanical properties. Pol3mi Int 2007 56 467-473. 

Silbert L, Ben Shlush I, Israel E, Porgador A, Kolusheva S, Jelinek R. Rapid chromatic detection of bacteria by use of a new biomimetic polymer sensor. Appl Environ Microbiol 2006 72 7339-7344. 

Biomimetic polymers. 2. Molecular recognition. 3. Supramolecular chemistry. 

Potential applications of peptide-polymer conjugates include drug delivery materials, optoelectronics, biosensors, tissue scaffolds, tissue replacement materials, hydrogels, adhesives, biomimetic polymers, lithographic masks, and templates for metallic or silica nanostructures. 

Iwasaki, Y., Tabata, E., Kurita, K., Akiyoshi, K. (2005). Selective cell attachment to a biomimetic polymer surface through the recognition of cell-surface tags. Bioconjug. Chem., 16, 567-575. 

Seal BL, Panitch A (2003) Physical polymer matrices based on affinity interactions between peptides and polysaccharides. Biomacromolecules 4 1572-1582 Seal BL, Panitch A (2006) Viscoelastic behavior of environmentally sensitive biomimetic polymer matrices. Macromolecules 39 2268-2274... 

Drotleff S, Lungwitz U, Breunig M, et al. (2004). Biomimetic polymers in pharmaceutical and biomedical sciences. Euro. J. Pharmaceutics and Biopharmaceutics. 58 385-407. 

Iwata R, Suk-In P, Hoven VP, Takahara A, Akiyoshi K, Iwasaki Y. Control of nanobiointerfaces generated from well-defined biomimetic polymer brushes for protein and cell manipulations. Biomacromolecules 2004 5(6) 2308-14. 

Antibiotic-resistant bacteria cause life-threatening infections in hospitals and society in general. There is a vital requirement to develop new antimicrobial agents, but this task involves extensive scientific trials. This chapter reviewed broad-spectrum polymeric antimicrobials, which are not susceptible to current resistance, and mechanisms of bacteria to mimic the antimicrobial action of natural HDP, which exert their effect by permeabilising the bacterial cytoplasmic membrane. Most cationic antimicrobial polymers appear to work in a manner similar to membrane-active AMP, such as magainin. The design and synthesis of different polymers, such as methacrylate-based copolymers, PPE, polynorbornene by-products, amphiphilc arylamide polymers and large polymers, have been studied as biomimetic polymers in different applications. 

J.E. Guillet, Biomimetic Polymer Catalysts for Important Photochemical Reactions, Can. Chem. News 52 (2000) 16. 

R. Zhang, PX. Ma, Biomimetic polymer/apatite composite scaffolds for mineraUzed tissue engineering, Macromol. Biosci. 4 (2)... 

In addition to the mussel adhesive proteins, DOPA is found in polychaete sandcastle worm glue secretions, which are in situ forming multiprotein cements deployed during constmction of tube-shaped brick and mortar shelters built from particulates that are available in the sandcastle worm environment. These interesting protein cements have been characterized and have led to the recent emergence of first-generation biomimetic polymer adhesives. 

To achieve this task, biomimetic polymers usually allow for the control of cellular processes, such as proliferation, differentiation or migration, or they are used to control material uptake into cells. While the former are of cmdal importance, especially in tissue regeneration and engineering, the latter is the prerequisite for gene and dmg delivery. " All these approaches involve a sophisticated polymer design, which ideally combines synthesis and modification steps with a high degree of spatial control over the applied modifications. 

Consequently, the scope of this chapter is to give an overview on the current developments of biomimetic polymers in biomedical applications including an introduction on cell-biomaterial interactions, applied biomimetic strategies, and synthesis and modification techniques for seleaed natural and S3mthetic polymers. Examples of recent studies using... 

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