Tissue replacement

Puskas, J.E. and Chen, Y. Biomedical application of commercial polymers and novel polyisobutylene-based thermoplastic elastomers for soft tissue replacement. Biomacromolecules, 5, 1141, 2004 GAK-GV, 7, 455 8, 526, 2004 (German). 

Schiraldi et al. [64] have developed this kind of material by combining silica particles and pHEMA. pHEMA is a biocompatible hydrogel that has been widely studied in the past decades due to its chemical-physical structure and mechanical properties. It has been widely used in ophthalmic prostheses (contact or intraocular lenses), vascular prostheses, drug delivery systems and soft-tissue replacement [65]. These authors have shown that by incorporating silica nanoparticles, the resulting hybrid material is highly biocompatible and promotes bone cell adhesion and proliferation of bone cells seeded on it.1 ... 

Alcohol is toxic to the liver, and prolonged use results in cirrhosis, a condition in which scar tissue replaces normal liver tissue, and impairs the ability of the liver to function. Ghronic use can also result in permanent damage to the GNS, partly due to a poor diet regimen and diminished intake of vitamin B1 (thiamine). 

Suchanek, W., and M. Yoshimnra, Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J. Mater. Res., 13(1), 94 (1998). 

Metallic biomaterials (metals such as Ti or its alloys and others) are used for the manufacture of orthopaedic implants due to their excellent biocompatibility with respect to electrical and thermal conductivity and their mechanical properties, e.g., for hard tissue replacement such as total hip and knee joints, for fracture healing aids such as bone plates and screws or dental implants. For example, Co-Cr-Mo alloys are employed for metal-on-metal hip bearings in total joint replacements. Problems with implants occur because of ion release in patients with metal implants. To control this ion release, the ultratrace determination of Co, Cr and Mo in the blood (or serum) and urine of patients with Co-Cr-Mo alloy hip implants is carried out routinely in the author s laboratory. The trace metal determination of Co, Cr and Mo in complex matrices such as urine and blood by ICP-MS is not trivial due to the low concentrations expected in the sub-ngmF1 range, the possible danger of contamination during sample collection, sample preparation and the... 

Well-known products include wound dressing, temporary skin, and connective-tissue replacement (BioFill , Gengiflex ) [7]. Numerous groups are working on these applications and investigating the healing effect of this external BC material (Table 2). 

Potential applications of peptide-polymer conjugates include drug delivery materials, optoelectronics, biosensors, tissue scaffolds, tissue replacement materials, hydrogels, adhesives, biomimetic polymers, lithographic masks, and templates for metallic or silica nanostructures. 

Contaminating antibodies in the negative control serum are cross-reacting with proteins from the specimen tissue. Replace the negative reagent control serum repeat staining protocol. 127-130... 

Correct answer = E. Griseofulvin accumulates in the infected, newly synthesized keratin-containing tissues making them unsuitable for the growth of the fungi. Therapy must be continued until normal tissue replaces infected tissue. This usually requires long-term therapy. 

Park S-H, Llinas A, Goel VK, Keller JC. Hard Tissue Replacements. In Bronzino JD, ed. The Biomedical Engineering Handbook. CRC Press. Boca Raton. FL. 1995, pp. 672-703. 

The use of hydrogels in the preparation of scaffolds for other applications such as dental pulp tissue replacement or mandible condylar reconstruction has also been tackled. 

Woerly, S. Plant, G.W. Harvey, A.R. Cultured rat neuronal and glial cells entrapped within hydrogel polymer matrices A potential tool for neural tissue replacement. Neurosci. Lett. 1996, 205, 197-201. 

Rinse the dropper with hot water and dry with a clean tissue. Replace the cap right after use. 

Mano, J.F. Sousa, R.A. Boesel, L.F. Neves, N.M. Reis, R.L. Bioinert, biodegradable and injectable polymeric matrix composites for hard tissue replacement state of the art and recent... 

In hard tissue replacement, polyurethane filled with hydroxyapatite is used. The composite must have high strength and stiffness and excellent creep and fatigue resistance. The material in the study met these requirements when hydroxyapatite was pretreated with hexamethylene diisocyanate. The treatment improved the adhesion between the matrix and the filler. ... 

Techniques to produce multiscale biomaterial scaffolds with designer geometries are the need of the hour to provide improved biomimetic properties for functional tissue replacements. While micrometer fibers generate an open pore stnicture, nanofibers support cell adhesion and facilitate cell-cell interactions. This was further proven by cell penetration studies, which showed superior ingrowth of cells into hierarchical structures. Mixed bimodal scaffolds of two different polymers are another promising approach, because they exhibit hierarchical pore/ surface systems and combine the beneficial properties of both polymers at two different scales. Vaiious 3D micro- and nanoscale multiscale scaffolds have been fabricated through various techniques and were found to have the potential to essentially recreate natural bone, cardiac, neural, and vascular tissues. 

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