Design of Biomimetic Antimicrobial Polymers

Sangeeta Kalal, Manish Kumar Rawal, Narendra Pal Singh Chauhan, AbolfazI Yazdanpanah, Rakshit Ameta and Masoud Mozafari 

The synthesis of polymers and oligomers that mimic the complex constructions and notable biological properties of proteins is crucial research with both fundamental and practical implications. Therefore, considerable work has gone into designing polymers, which mimic important physico-chemical properties, such as the existence of both cationic and hydrophobic groups, of naturally occurring AMP [11-14], 

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Antibiotic-resistant bacteria cause life-threatening infections in hospitals and society in general. There is a vital requirement to develop new antimicrobial agents, but this task involves extensive scientific trials. This chapter reviewed broad-spectrum polymeric antimicrobials, which are not susceptible to current resistance, and mechanisms of bacteria to mimic the antimicrobial action of natural HDP, which exert their effect by permeabilising the bacterial cytoplasmic membrane. Most cationic antimicrobial polymers appear to work in a manner similar to membrane-active AMP, such as magainin. The design and synthesis of different polymers, such as methacrylate-based copolymers, PPE, polynorbornene by-products, amphiphilc arylamide polymers and large polymers, have been studied as biomimetic polymers in different applications. 

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