Polymer-peptide conjugates

Collier JH, Messersmith PB (2004) Self-assembling polymer-peptide conjugates nanostructural tailoring. Adv Mater 16 907-910... 

Diez I, Hahn H, Ikkala O, Bomer HG, Ras RHA (2010) Controlled growth of silver nanoparticle arrays guided by a self-assembled polymer-peptide conjugate. Soft Matter 6 3160-3162... 

Kiihnle H, Bomer HG, (2009) Biotransformation on polymer-peptide conjugates a versatile tool to trigger micro structure formation. Angew Chem Int Ed 48 6431-6434... 

Conan J. Fee, Hybrid Systems Engineering Polymer-Peptide Conjugates Volume 36 (2009)... 

Figure 29 Schematic illustration of the approach combining (1) peptide-directed self-assembly of polymer-peptide conjugates and (2) polymerization of positioned diacetylene moieties. Peptide-polymer conjugates (top, a) first organize into supramolecular assemblies (top, b), which exhibit a distinct superhelical structure (bottom) this can be converted into conjugated polymers (red) under retention of their previously assembled structure (top, c). Reprinted with permission from Frauenrath, H. Jahnke, E. Chem. Eur. J. 2008, 14, 2942. Copyright 2007, Wiley-VCH.

B. R. Line, A. Mitra, A. Nan and H. Ghandehari, Targeting tumor angiogenesis Comparison of peptide and polymer-peptide conjugates, J. Nucl. Med., 46,1552-1560 (2005). 

Tomiyama, T., et al, Effect of introduction of chondroitin sulfate into polymer-peptide conjugate responding to intracellular signals. Nanoscale Research Letters, 6 (1) 1-7,2011. 

Fig. 13 pH-controlled switch of a polymer—peptide conjugate with two switch defects in the peptide segment two-step process from the fully disturbed peptide segment (left) via two intermediate structures (middle ) to the undisturbed aggregator (right) after RAFT polymerization results in a fibrillar microstructure. Reprinted with permission from [108]. Copyright (2007)... 

Kros et al. reported a polymer-peptide conjugate prepared via nickel-mediated NCA polymerization and a subsequent polymerization of an isocyanide, again using the nickel complex as initiator [111]. The active catalyst is attacked by the more electrophilic isocyanide and the coordinated amine reacts with the isocyanide to yield a carbene-like initiator for the isocyanide polymerization (see Fig. 14). The product can be purified from free residual homopolymers by selective solvent... 

Figure 21 Synthesis of SGI-functionalized peptides as precursors for polymer-peptide conjugates.

Liu, T.-Y, Hussein, W.M., Jia, Z., et al. Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer. Biomacromolecules 14, 2798-2806 (2013). doi 10.1021/bm400626w... 

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