Design polymer

Poly(orthoesters) represent the first class of bioerodible polymers designed specifically for dmg deUvery appHcations (52). In vivo degradation of the polyorthoester shown, known as the Al amer degradation, yields 1,4-cydohexanedimethanol and 4-hydroxybutyric acid as hydrolysis products (53). 

Pitches can be transformed to a mesophase state by further chemical and physical operations. Heat treatment of conventional pitches results in additional aromatic polymeriza tion and the distillation of low molecular weight components. This results in an increase in size and concentration of large planar aromatic molecular species whereupon the precursor pitch is transformed to a mesophase state exhibiting the characteristics of nematic Hquid crystals (1). Additional heat treatment converts the mesophase pitch to an infusible aromatic hydrocarbon polymer designated as coke. 

Heitz, W. Polymeric Reagents. Polymer Design, Scope, and Limitations. Vol. 23, pp. 1—23. 

Design of injection molding equipment to produce car bumpers made from polymers Designing feedback control systems for bioreactors... 

R Duncan, M Bhakoo, PA Flanagan, D Sgouras. Evaluation of the biocompatibihty of soluble synthetic polymers designed as drug carriers. Proc Int Symp Controlled Release Bioact Mater 15 121-122, 1988. 

A Nathan, J Kohn. Amino acid derived polymers. In SW Shalaby, ed. Biomedical Polymers Designed-to-Degrade Systems. Cincinnati, OH Hanser/Gardner, 1994, pp 117-151. 

POTENZONE and doherty Computer-Assisted Polymer Design... 

Polymers designed with this technique have a number of important aspects in common with proteins. First of all, the transition from a liquid-like globule into a frozen state occurs as a first order phase transition. Further, the frozen state itself has an essential stability margin, which is determined by the design parameters. As in real proteins, neither a large variation of temperature or other environmental conditions, nor a mutational substitution of several monomers leads to any change in basic state conformation. In this respect the ability of sequence design to capture certain essential characteristics of proteins seems quite plausible. 

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