Polymeric Antimicrobials

Jiang and Zhu (2001) reported on the synthesis of poly(p-carboxyphe-noxy succinic monoester anhydride) and poly(p-carboxyphenoxy adipic monoester anhydride) (PCPSM and PCPAM), and the copolymer P(CPAM-CPSM) as polymeric antimicrobial prodrugs for diseases such as malaria and hepatitis B. They also reported that PCPSM exhibits strong fluorescence, the intensity of which increases linearly with its molecular weight (Jiang et al., 2001a,b). They showed that when co-polymerized the fluorescence is maintained, though diminished approximately in proportion to the copolymer composition. 

PVA film/ Tetraborate (TB)/ Proteolytic enzyme Protease C (Pr)+, a cationic polymeric antimicrobial (AM=Metacid) 235... 

Gettings RL, White WC (1987) Formation of polymeric antimicrobial surfaces from organofunctional silanes. Polym Mater Sci Eng 57 181-185... 

Disclosed are dry, disposable, polymeric antimicrobial-applying products having sustained-release antimicrobial activity. They corrsist essentially of a polymeric material, such as a natrual polymer, synthetic polymer or mixture thereof, in the form of fibres, yarrrs, woverr, non-woven and knitted fabrics, sheets and films, and an amine salt antimicrobial agent, which is releasably impregnated into... 

Alconate . [Rhone-Poulenc Surf.] Sttlfosttccinates surfactants, wetting agent dispersant penetrant Aickener, conditioner for personal cate prods., tug shanqxios, industrial and mining applies. enuilsifier in emulsion polymerization antimicrobial for daridruff shanqxxis. 

Antibiotic-resistant bacteria cause life-threatening infections in hospitals and society in general. There is a vital requirement to develop new antimicrobial agents, but this task involves extensive scientific trials. This chapter reviewed broad-spectrum polymeric antimicrobials, which are not susceptible to current resistance, and mechanisms of bacteria to mimic the antimicrobial action of natural HDP, which exert their effect by permeabilising the bacterial cytoplasmic membrane. Most cationic antimicrobial polymers appear to work in a manner similar to membrane-active AMP, such as magainin. The design and synthesis of different polymers, such as methacrylate-based copolymers, PPE, polynorbornene by-products, amphiphilc arylamide polymers and large polymers, have been studied as biomimetic polymers in different applications. 

Getman G. An advanced polymeric antimicrobial for plastic materials including polyolefin resins. International Polyolefins, conference proceedings. Society of Plastics Engineers 2008. 

FORMATION OF POLYMERIC ANTIMICROBIAL SURFACES FROM ORGANOFUNCTIONAL SILANES... 

The ability to create essentially irreversible polymeric coatings of cationic silanes on surfaces and the ability of these modified surfaces to kill and/or control microorganisms has been demonstrated in laboratory and real world situations. A large number of microbological techniques have been found useful in determining the antimicrobial activity of a wide variety of surfaces with polymeric antimicrobials. This has provided considerable insight into the mode of antimicrobial action of these compounds. 

Formation of Polymeric Antimicrobial Surfaces From Organo-Functional Silanes... 

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