BAYER 205

Scientists at Bayer implemented traffic lights for the prioritization of molecules from the HTS hits. Their score is based on solubility, lipophilicity, molecular weight, Polar Surface Area (PSA), and number of rotatable bonds. [Pg.242]

All Molecules Processed Red/Yellow Alerts FDA Mutagenicity Alerts Octanol/water logP (CLOGP) [Pg.243]

Bioavailability Rule of Five Bioavailability Abbott Score PharmaAlgorithms pKa Syracuse Solubility Octanol/water logP (KOWWIN) [Pg.243]

Andrews Binding Energy Polar/Non-Polar Surface Area 3D Clark log(brain/blood) [Pg.243]

These descriptors are similar to R05 criteria, since PSA directly correlates with the sum of hydrogen-bond donors and acceptors. Water solubility is also critically related to permeability and bioavailability. [Pg.243]

Welter O, Bayer T and Greschner J 1991 Micromachined silicon sensors for scanning force microscopy J. Vac. Sc/. Technol. B 9 1353... [Pg.1723]

The utility of acid-base titrimetry improved when NaOH was first introduced as a strong base titrant in 1846. In addition, progress in synthesizing organic dyes led to the development of many new indicators. Phenolphthalein was first synthesized by Bayer in 1871 and used as a visual indicator for acid-base titrations in 1877. Other indicators, such as methyl orange, soon followed. Despite the increasing availability of indicators, the absence of a theory of acid-base reactivity made selecting a proper indicator difficult. [Pg.278]

Bayer s alumina Bayferrox Bayhibit AM Bay leaves Bayleton... [Pg.93]

Xanthenes date from 1871 when von Bayer synthesized fluorescein (5) by the condensation of two moles of resorcinol with one mole of phthaUc anhydride in the presence of concentrated sulfuric acid (1). [Pg.398]

The above batch process has undergone numerous refinements to improve yields, processing characteristics, purity, and storage stabiUty, but it remains the standard method of manufacture for these products. Recentiy a continuous process has been reported by Bayer AG (6) wherein the condensation is carried out in an extmder. The by-products are removed in a degassing zone, and the molten polymer, mixed with stabilizers, is subsequendy cracked to yield raw monomer. [Pg.178]

See also in sourсe #XX -- [ Pg.61 ]

See also in sourсe #XX -- [ Pg.28 , Pg.146 , Pg.507 , Pg.543 ]

See also in sourсe #XX -- [ Pg.36 , Pg.40 , Pg.41 ]

See also in sourсe #XX -- [ Pg.122 , Pg.130 , Pg.132 , Pg.139 , Pg.142 , Pg.270 , Pg.271 , Pg.508 , Pg.521 , Pg.529 , Pg.538 , Pg.671 , Pg.735 , Pg.901 , Pg.910 , Pg.913 , Pg.915 , Pg.919 , Pg.968 ]

See also in sourсe #XX -- [ Pg.47 ]

See also in sourсe #XX -- [ Pg.14 , Pg.15 , Pg.116 , Pg.272 , Pg.273 , Pg.281 , Pg.290 ]

See also in sourсe #XX -- [ Pg.24 , Pg.24 , Pg.94 , Pg.98 , Pg.106 ]

See also in sourсe #XX -- [ Pg.111 ]

See also in sourсe #XX -- [ Pg.8 , Pg.80 , Pg.370 ]

See also in sourсe #XX -- [ Pg.4 , Pg.33 , Pg.366 , Pg.499 , Pg.505 ]

See also in sourсe #XX -- [ Pg.39 , Pg.43 , Pg.159 ]

See also in sourсe #XX -- [ Pg.93 ]

See also in sourсe #XX -- [ Pg.161 ]

See also in sourсe #XX -- [ Pg.170 , Pg.180 ]

See also in sourсe #XX -- [ Pg.8 , Pg.80 , Pg.370 ]

See also in sourсe #XX -- [ Pg.6 , Pg.7 , Pg.335 , Pg.398 , Pg.404 , Pg.430 ]

See also in sourсe #XX -- [ Pg.3 ]

See also in sourсe #XX -- [ Pg.4 , Pg.15 ]

See also in sourсe #XX -- [ Pg.138 ]

See also in sourсe #XX -- [ Pg.5 ]

See also in sourсe #XX -- [ Pg.346 , Pg.362 , Pg.363 , Pg.368 ]

See also in sourсe #XX -- [ Pg.8 ]

See also in sourсe #XX -- [ Pg.620 ]

See also in sourсe #XX -- [ Pg.10 , Pg.21 , Pg.117 , Pg.125 , Pg.154 , Pg.166 , Pg.168 , Pg.171 , Pg.236 ]

See also in sourсe #XX -- [ Pg.61 ]

See also in sourсe #XX -- [ Pg.78 , Pg.103 ]

See also in sourсe #XX -- [ Pg.283 ]

See also in sourсe #XX -- [ Pg.52 , Pg.70 , Pg.119 , Pg.185 , Pg.193 , Pg.203 , Pg.242 ]

See also in sourсe #XX -- [ Pg.171 , Pg.310 , Pg.406 ]

See also in sourсe #XX -- [ Pg.2 ]

See also in sourсe #XX -- [ Pg.222 ]

See also in sourсe #XX -- [ Pg.145 , Pg.152 ]

See also in sourсe #XX -- [ Pg.422 ]

See also in sourсe #XX -- [ Pg.241 ]

See also in sourсe #XX -- [ Pg.19 , Pg.60 ]

See also in sourсe #XX -- [ Pg.13 , Pg.15 , Pg.20 , Pg.22 , Pg.26 , Pg.63 , Pg.67 , Pg.178 ]

See also in sourсe #XX -- [ Pg.4 ]

See also in sourсe #XX -- [ Pg.189 , Pg.375 , Pg.384 , Pg.385 ]

See also in sourсe #XX -- [ Pg.53 ]

See also in sourсe #XX -- [ Pg.184 ]

See also in sourсe #XX -- [ Pg.1425 ]

See also in sourсe #XX -- [ Pg.168 , Pg.215 , Pg.545 ]

See also in sourсe #XX -- [ Pg.181 ]

See also in sourсe #XX -- [ Pg.92 ]

See also in sourсe #XX -- [ Pg.605 ]

See also in sourсe #XX -- [ Pg.2 , Pg.33 , Pg.576 ]

See also in sourсe #XX -- [ Pg.8 , Pg.80 , Pg.370 ]

See also in sourсe #XX -- [ Pg.215 ]

See also in sourсe #XX -- [ Pg.616 ]

See also in sourсe #XX -- [ Pg.355 ]

See also in sourсe #XX -- [ Pg.26 , Pg.53 ]

See also in sourсe #XX -- [ Pg.12 ]

See also in sourсe #XX -- [ Pg.161 ]

See also in sourсe #XX -- [ Pg.15 , Pg.210 , Pg.211 , Pg.277 , Pg.420 , Pg.453 , Pg.551 , Pg.698 ]

See also in sourсe #XX -- [ Pg.4 , Pg.6 , Pg.7 , Pg.9 , Pg.11 , Pg.12 , Pg.13 , Pg.16 , Pg.224 , Pg.226 , Pg.227 , Pg.232 , Pg.234 , Pg.236 , Pg.239 ]

See also in sourсe #XX -- [ Pg.184 ]

See also in sourсe #XX -- [ Pg.53 ]

See also in sourсe #XX -- [ Pg.64 , Pg.67 , Pg.90 ]

See also in sourсe #XX -- [ Pg.290 ]

See also in sourсe #XX -- [ Pg.22 , Pg.36 , Pg.63 , Pg.64 , Pg.65 , Pg.66 , Pg.67 , Pg.68 , Pg.71 , Pg.73 , Pg.78 , Pg.79 , Pg.82 , Pg.86 , Pg.88 , Pg.103 , Pg.104 , Pg.105 , Pg.110 , Pg.117 , Pg.120 , Pg.221 , Pg.223 , Pg.224 , Pg.229 , Pg.254 , Pg.290 , Pg.291 , Pg.293 , Pg.296 , Pg.298 , Pg.300 , Pg.301 , Pg.304 , Pg.305 , Pg.307 , Pg.308 , Pg.316 , Pg.318 , Pg.319 , Pg.325 , Pg.327 , Pg.354 , Pg.357 , Pg.359 , Pg.361 , Pg.363 , Pg.365 , Pg.366 , Pg.368 ]

See also in sourсe #XX -- [ Pg.73 , Pg.171 ]

See also in sourсe #XX -- [ Pg.79 ]

See also in sourсe #XX -- [ Pg.15 , Pg.32 , Pg.67 , Pg.69 , Pg.70 , Pg.92 , Pg.128 , Pg.186 , Pg.222 , Pg.244 ]

See also in sourсe #XX -- [ Pg.13 , Pg.59 , Pg.202 ]

See also in sourсe #XX -- [ Pg.534 ]

See also in sourсe #XX -- [ Pg.272 , Pg.318 ]

See also in sourсe #XX -- [ Pg.78 ]

See also in sourсe #XX -- [ Pg.259 ]

See also in sourсe #XX -- [ Pg.35 ]

See also in sourсe #XX -- [ Pg.8 , Pg.271 , Pg.326 ]

See also in sourсe #XX -- [ Pg.449 ]

See also in sourсe #XX -- [ Pg.17 ]

See also in sourсe #XX -- [ Pg.176 , Pg.187 , Pg.188 , Pg.369 , Pg.431 , Pg.445 , Pg.450 , Pg.456 , Pg.522 ]

See also in sourсe #XX -- [ Pg.295 , Pg.372 , Pg.374 ]

See also in sourсe #XX -- [ Pg.111 , Pg.118 ]

See also in sourсe #XX -- [ Pg.187 ]

See also in sourсe #XX -- [ Pg.10 , Pg.252 ]

See also in sourсe #XX -- [ Pg.316 , Pg.358 ]

See also in sourсe #XX -- [ Pg.105 ]

See also in sourсe #XX -- [ Pg.29 ]

See also in sourсe #XX -- [ Pg.35 ]

See also in sourсe #XX -- [ Pg.425 , Pg.438 ]

See also in sourсe #XX -- [ Pg.202 , Pg.203 ]

See also in sourсe #XX -- [ Pg.3 , Pg.4 ]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...