Nifedipine, Bayer compound

It is closely related to the Bayer compound nifedipine currently under investigation in Europe as an antianginal agent (40). 

Generally, the dihydropyridine CCBs have evolved into three distinct subclasses based on their pharmacokinetics and pharmacodynamics. Early dihydropyridines such as nifedipine and nicardipine are characterized by a rapid onset of action and short duration of action due to limited half-life lives, thus requiring twice-daily dosing (Bayer, 2004). In addition, these short-acting compounds may have potential detrimental effects... 

Mannhold R, Rodenkirchen R and Bayer R, Haus W, The importance of drug ionization for the action of calcium antagonistsand related compounds, Arzneim.-Forsch., 34, 407-409 (1984). NB Tetrabutylammonium hydroxide used as base. Cited in Nifedipine, Ali SL, APDS, 18,231-288 (1989). 

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