Bayer antimalarials

Initially approved in the 1930s as antimalarial drug, quinacrine (2) became one of the first potential substitutes to quinine. The total synthesis of quinacrine would be achieved in 1931 by German scientists at Bayer,and it would be subsequently marketed as Mepacrine or Atebrine. However, quinacrine would soon be replaced by another synthetic and more efficient antimalarial drug, chloroquine (3). 

Tresochin/Bayer Imagon/Astra (it was until recently the best antimalarial drug, now rendered useless in most areas drug resistance acquired by the parasite)... 

Sulphanilamide (3), the parent member of this class, was synthesized by Gelmo [4] in 1908 and later by Heinrich Hoerlein of Bayer, who was awarded the German Patent 226,239 on May 18,1909 [5], long before its antimicrobial activity was discovered. Klarer and Mietzsch working at LG. Farbenindustrie in Germany synthesized a variety of azo dyes as continuation of EhrUch s interest in dyes as antimalari-... 

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