Bayer’s strain

Concept of I Strain Bayer s Strain Theory Limitations of Strain Theory Eused Ring Systems Stability of Ring Systems... 

Reactivity of strongly bonded molecules was considered by Thiele [60], who introduced the concept of residual valence. This is tied in with Bayer s strain theory in the sense that a solution for the same question was sought. Whereas the stereochemistry of the cycloalkanes made Bayer s theory obsolete, the later introduction of resonance more or less confirmed Thiele s intuition. 

The chemical properties of cycHc ketones also vary with ring size. Lower members (addition reactions, than corresponding acycHc ketones. The Cg—C 2 ketones are unreactive, reflecting the strain and high enol content of medium-sized ring systems. Lactones are prepared from cycHc ketones by the Bayer-ViUiger oxidation reaction with peracids. S-Caprolactone is manufactured from cyclohexane by this process ... 

Actinomycin F, Actinomycin KS4 KS4. An antibiotic produced by cultures of actinomycin C-elaborat-ing strains of Streptomyces, such as Streptomyces BOP 476 (NRRL 2580) and Sirt-piomy r. chrysomaltus (NRRL 2250). Considered to be a derivative of actinomycin C2 amino acid analysis indicates that the prolines present in actinomycin C2 are substituted by sarcosine in actinomycin I, Production by controlled biosynthesis Schmidt-Kastner. Naturwiss. 43, 131 (1956) idem, Ann. N.Y. Acad. Set. 89, 199 (1960) Schmidt-Kastner, Hackmann, U.S. pat. 3,219,544 (1965 to Bayer). 

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