Yoshida sarcoma

Widder KJ, Marino PA, Morris RM, Howard DP, Poore GA, Senyei AE (1983a) Selective targeting of magnetic albumin microspheres to the Yoshida sarcoma ultrastructural evaluation of microsphere disposition. Eur J Cancer Clin Oncol 19 141-147. 

BIOLOGICAL ACTIVITY OF PODOLACTONES Anti-tumoral Activity, a) Yoshida Sarcoma. 

The in vitro bioactivitivity of 29 podolactones, 15 of them natural products, against cultured Yoshida Sarcoma cells [64-65] was investigated by Hayashi s group during the period between 1975 and 1979. 

Table 1. Citotoxicity of natural and synthetic podolactones against Yoshida Sarcoma...

Antitumor activity of norditerpenpoid dilactones in Podocarpus plants structure-activity relationship on in vitro citotoxicity against Yoshida Sarcoma. Hayashi, Y. Matsumoto, T Tashiro, T. Gann 1979, 70,365-369. 

Effective on Walker carcinosarcoma, Yoshida sarcoma, and Jensen sarcoma in vivo some action on lymphoma NK/Ly, no effect in sarcoma 37, reduction of survival time for Guer sarcoma some weight loss doses to 150 mg/kg not lethal 512... 

The starting material for the isolation were cells of the Jensen and Yoshida sarcomas, and the procedure used took into account the possible interference of the nucleoproteins. Yields of 0.1 to 0.2 % based on the fresh weight of the cells were obtained (Table III). Above an ionic strength of 0.3 n the protein is completely soluble below this value, the solubility decreases steadily, but a sharp inflection point in the solubility curve is missing. Addition of ATP increases the solubility. 

A convenient synthesis was reported for l,3-bis(tetrahydro-2-fur-anyl)-5-fluorouracil (Thf2 FU), whose toxicity and antitumor activity were compared with Ftorafur (Thf-FU) and FU. The oral LDc in mice was approximately 3-fold greater than that observed for Thf-FU, ich was much less toxic than FU. Thf -FU slowly hydrolyzed to FU in vivo and showed significant antitumor effects at 0.15-0.45 mmol/kg (p.o.) against Ehrlich and AH-130 carcinomas, sarcoma 180, Yoshida sarcoma and Walker 256 carcinosarcoma. The most active in a series of 1-alkyIcarbamoyl derivatives of FU was the 1-jt-butylcarbamoyl compound, which gave an of... 

Rodent (Yoshida sarcoma cells) DNA cross links No data (+) Bedford and Fox 1981... 

Widder, K. J., Morris, R. M., Poore, G. A., Howard, D. P., and Senyei, A. E. (1983) Selective targeting of magnetic albumin microspheres containing low-dose doxorubicin total remission in Yoshida sarcoma-bearing rats. Eur. J. Cancer Clin. Oncol. 19, 135-139. 

Early in vivo experiments (1913) showed that garlic and its compounds acted against mmors in mice, with similar results obtained by others (Reuter, Koch, and Lawson, in Garlic, pp. 178-186). Not only could mmor growth be inhibited, but alliin as freshly obtained from garlic bulbs and directly injected into rat sarcomas, resulted in reduction and dissipation. Similar results were obtained for intramuscular injections. Others, however, reported otherwise. On the other hand, allicin deactivated ehrlich ascites mmor cells, and also deactivated cells of Yoshida sarcoma (a mammary tumor). Other examples are described in the reference, with the note that fresh garlic neutralizes cancer cell virulence without compromising the immune response, whereby atumals at least become immune to untreated mmor cells. 

Ishidate et al. 133,205-208 found that isoxazolidinium salts 47a and the like are effective in the therapy of malignant tumors and have strong biological activity toward Yoshida sarcoma. It appears that the salt 47d is inactive to Yoshida sarcoma.153,56,2°9 The relation between the size of the alkyl substituent in the salt 75 and its antibacterial action was investigated. The bacteriostatic action is maximal with R = CI2H2J, which is still active toward Staphylococcus aureus 209P with the maximum dilution of 400,000. For use as a disinfectant or a bacteriocide the salt of 75 is possible.30... 

The isozymes of mammalian synthetase and the bacterial enzyme show similarities in subunit weight. TheE. coli enzyme was found to be a monomer of 56,000 daltons (37), and the rat liver acidic isozyme and the Novikofif ascites enzyme (45) have a molecular weight of 55,000-60,000. The A. vinelandii enzyme is a native dimer of 110,000 daltons (14) and the rat skeletal and Yoshida sarcoma enzymes are dimers of... 

Yoshida sarcoma ED50, 7.4jag/ml ORGANISM Naja naja atra (Chordata/Reptilia) Formosan cobra reference 212... 

Nitroxides suppressed tumorigenesis (Metodiewa etal. 1997). The medication of Tempicol-2 [4-hydroxy-4-(2-picolyl-2,2,6,6-tetramethylpiperidine-1-oxyl], a stable free radical, to rats bearing 3 day-old Yoshida sarcoma (promotion phase) induced both growth inhibition and apoptotic cell death, comparable to the effects of Tempace and Rutoxyl [ rutin/4 - acetamide-1 -hydroxyl-2,2,6,6-tetramethyl-piperidinium] under the same experimental conditions (Metodiewa et al. 1998). 

Schizophyllan Schizophyllum commune sarcoma-37, sarcoma-180, Ehrlich carcinoma, and Yoshida sarcoma in-vivo [33]... 

Goseki, N., Yamazaki, S., Endo, M., Onodera, T., Kosaki, G., Hibino, Y., and Kuwahata, T., 1992, Antitumor effect of methionine-depleting total parenteral nutrition with doxorubicin administration on Yoshida sarcoma-bearing rats. Cancer 69 1865-1872. 

This formulation, which is often referred to as SPG, consists mainly of the benzylidene-D-glucoside of podophyllotoxin. It is active against Ehrlich ascites tumour (in vitro and in vivo), Yoshida sarcoma, C3H and C3HO tumours, S 180 and L 1210 [2, 229-233]. Mastocytoma cell multiplication is inhibited by 0-63-1-3 pg/ml of the drug, but it does not inhibit DNA... 

UDP-N-Acetylgluco-samine-2 -epimerase strong decrease Morris hepatomas Yoshida sarcoma, Yoshida ascites tumor Reutter et al. 1970, Kikuchi et al. 1971, Harms et al. 1973, Grunholz 1978 Kikuchi (2/. 1971... 

N-Acetylmannosamine-kinase decrease Morris hepatomas, Yoshida sarcoma, Yoshida ascites hepatoma Kikuchi et al. 1971, Grunholz 1978... 

Ling, P. R., Istfan, W. N., Lopes, M. S, Babayan, K. V., Blackburn, L. G. Bistrian, R. B. (1991). Structured lipid made from fish oil and medium-chain triglycerides alters tumor and host metabolism in Yoshida-sarcoma-bearing rats. Am. J. Clin. Nutr., 53,1177-84. 

Suppression of cell membrane transport plays a role in the resistance to nitrogen mustard (HN2) by the Yoshida sarcoma cells. Metabolism of cyclophosphamide (3a, cytoxan) by rat hepatic microsomes has been reported. The active metabolite 4 is formed by a three-step enzymatic reaction. 

Emetine - As an inhibitor of protein synthesis at the transcription level, emetine is also active against leukemias L-1210 and P-388, B16 melanomas, Ehrlich ascites carcinoma and Yoshida sarcoma. Pharmacologic studies showed that it effects a sympathetic blockade, antagonizes hyal-uronldase, inhibits oxydative N-demethylatlon of aminopyrine and N-ethyl-morphlne as well as the S-demethylation of 6-MP riboside in vitro. 2,143... 

A number of experiments have been carried out on Yoshida sarcoma connected with lysosomal enzymes by Japanese investigators. 

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