Possibilities for Interference B

Risk of thrombosis Optimal adjustment Risk of bleeding 

Increased intake of vitamin K-rich food Damage to vitamin K-producing intestinal bacteria by antibiotics  

Inhibition of enteral coumarin absorption by adsorbents, e.g., antacids, medicinal charcoal Inhibition of hepatic coumarin metabolism, e.g., by cimetidine, metronidazole  

Acceleration of hepatic coumarin metabolism enzyme induction, e.g., by carbamazepine, rifampicin  

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