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Water-soluble vitamin multivitamin

Water-soluble vitamins removed by hemodialysis (HD) contribute to malnutrition and vitamin deficiency syndromes. Patients receiving HD often require replacement of water-soluble vitamins to prevent adverse effects. The vitamins that may require replacement are ascorbic acid, thiamine, biotin, folic acid, riboflavin, and pyridoxine. Patients receiving HD should receive a multivitamin B complex with vitamin C supplement, but should not take supplements that include fat-soluble vitamins, such as vitamins A, E, or K, which can accumulate in patients with renal failure. [Pg.394]

Recently, Prasad et al. cloned a mammalian Na+-dependent multivitamin transporter (SMVT) from rat placenta [305], This transporter is very highly expressed in intestine and transports pantothenate, biotin, and lipoate [305, 306]. Additionally, it has been suggested that there are other specific transport systems for more water-soluble vitamins. Takanaga et al. [307] demonstrated that nicotinic acid is absorbed by two independent active transport mechanisms from small intestine one is a proton cotransporter and the other an anion antiporter. These nicotinic acid related transporters are capable of taking up monocarboxylic acid-like drugs such as valproic acid, salicylic acid, and penicillins [5], Also, more water-soluble transporters were discovered as Huang and Swann [308] reported the possible occurrence of high-affinity riboflavin transporter(s) on the microvillous membrane. [Pg.264]

In contrast to the dissolution criteria used for water-soluble vitamins, the hierarchy for index minerals is based on their importance in public health. For example, iron was chosen as the number one index mineral because iron deficiency is the most prevalent condition in the United States and because iron is present in almost all the multivitamin-mineral combination products currently available on the... [Pg.413]

Assay of Water-soluble Vitamins (WSVs) in Multivitamin Tablets... [Pg.138]

The SP procedure of water-soluble vitamins from multivitamin tablets is particularly challenging due to the diverse analytes of varied hydrophobicities and pfC. Water-soluble vitamins (WSVs) include ascorbic acid (vitamin C), niacin, niacinamide, pyridoxine (vitamin B ), thiamine (vitamin Bj), folic acid, riboflavin (vitamin B2) and others. While most WSVs are highly water soluble, riboflavin is quite hydrophobic and insoluble in water. Folic acid is acidic while pyridoxine and thiamine are basic. In addition, ascorbic acid is light sensitive and easily oxidized. The extraction strategy employed was a two-step approach using mixed solvents of different polarity and acidity as follows ... [Pg.138]

FIGURE 7 HPLC chromatogram of water-soluble vitamin in multivitamin tablets. See Reference 33 for details. Reprinted with permission from Reference 33. [Pg.140]

Finally, we come to the last of the vitamins that appear on the contents list of my multivitamin pill—pantothenic acid. This water-soluble vitamin serves a single purpose in physiology and biochemistry it is a precursor to a far more complex molecule known as coenzyme A or, simply, CoASH. [Pg.204]

Water-soluble vitamins in formulations have been determined by use of ion-pair chromatography. The vitamins include several B vitamins as well as niacin, folic acid, and ascorbic acid (565). Vitamins D and Da were rapidly separated on reverse phase columns (247) as are vitamins A, D, and E in multivitamin tablets (564). Addition of silver ions to the mobile phase has been shown to increase the flexibility inherent in RPC by complexing with the unsaturated bonds and thereby decreasing the retention factor. This effect is also observed with other unsaturated drug molecules including steroids (247). Vitamin A and related compounds have... [Pg.151]

A large number of methods have been developed for analysis of water-soluble vitamins simultaneously in pharmaceutical products (like multivitamin tablet supplements). In fact, for these products no particular sample preparations are required and the high concentrations simplify the detection, enabling the use of UV [636]. The use of MS is also reported [637]. As well, Moreno and Salvado [638] reports also the use of a unique SPE cartridge (C18) for separating fat-soluble and water-soluble vitamins, which are, then analyzed using different chromatographic systems. [Pg.637]

M. C. Gennaro, Separation of water-soluble vitamins by reversed-phase ion-interaction-reagent high-performance liquid chromatography Application to multivitamin pharmaceuticals, J. Chromatogr. Sci., 29 410(1991). [Pg.245]

Among the water-soluble vitamins subject to photodegradation during administration, thiamine, ascorbic acid, and riboflavine must be considered. A multivitamin product containing all of these vitamins was added to both 0.9% NaCl and 5% dextrose infusion solutions packaged in PVC and Clearflex containers. These admixtures were then exposed to photonic energy (2000 lux) for 24 hours and showed a rapid degradation of both riboflavine and ascorbic acid (95). [Pg.422]

Vitamins In particular, water-soluble vitamins have to be provided in adequate quantities. With a carbohydrate diet and alcoholic liver disease, the daily requirement is higher. A daily intake of multivitamins, best combined with trace elements and minerals, is recommended. As a rule, liposoluble vitamins are best administered by parenteral route due to inadequate absorption. The therapeutic significance of zinc (s. pp 50, 99) should always be borne in mind. (34, 153, 155,169)... [Pg.278]

The potential of PBI LC-MS in the analysis of various vitamins was explored by Careri et al. [99-100]. The fat-soluble vitamins A, D, and E were analysed in food and multivitamin preparations [99]. Absolute detection limits in SIM mode were 0.6-25 ng after fast leversed-phase separation using a 97% aqueous methanol as mobile phase. Mass spectra in El, positive-ion and negative-ion Cl were obtained and discussed. The mass-spectral and quantitative performance of PBI LC-MS in the analysis of eleven water-soluble vitamins was also explored [100]. Detection limits were determined in SIM mode under positive-ion Cl, and were below 15 ng for ascorbic acid, nicotinamide, nicotinic acid, and pyridoxal, around 100 ng for dehydroascorbic acid, panthothenic acid, and thiamine, and above 200 ng for biotin, pyridoxamime, and pyridoxine. Riboflavine was not detected. [Pg.97]

Figure 6.5. HPLC chromatograms showing the analysis of water-soluble vitamins in multivitamin capsules tablets. Reprinted with permission from reference 17. Figure 6.5. HPLC chromatograms showing the analysis of water-soluble vitamins in multivitamin capsules tablets. Reprinted with permission from reference 17.
Immediate treatment with large doses (50-KX) mg) of intravenous thiamine may produce a measurable decrease in cardiac output and increase in peripheral vascular resistance as early as 30 minutes after the initial injection. Dietary supplementation of thiamine is not as effective because ethanol consumption interferes with thiamine absorption. Because ethanol also affects the absorption of most water-soluble vitamins, or their conversion to the coenzyme form, Al Martini was also given a bolus containing a multivitamin supplement. [Pg.377]

An overpressured layer chromatographic procedure, with photodensitometric detection for the simultaneous determination of water-soluble vitamins in multivitamin pharmaceutical preparations, was developed and evaluated. HPTLC on silica gel plates with 1-butanol-pyridine-water (50 35 15 vol/vol) as mobile phase was used. The quantitation was carried out without derivatization [vitamin B2 (Rf value 0.30), vitamin Bg (Rf value 0.64), folic acid (Rf value 0.37), nicotinamide (Rf value 0.80), and vitamin C (Rf value 1.02)] or after spraying ninhydrin reagent [calcium panthothenate (Rf value 0.72)] or 4-demethylaminocin-namaldehyde [vitamin B12 (Rf value 1.84) and biotin (Rf value 0)]. [Pg.1159]

Vitamin B12 (cobalamine) is needed to metabolize fatty adds and amino acids and to synthesize DNA in cells. Vitamin C also has several functions. It is needed to synthesize collagen, the most abundant protein in the body, but it also acts as an antioxidant, helping to reduce the risk of developing chronic diseases like heart disease and cancer. Water-soluble vitamins are not stored in the body. Because they are eliminated in urine, a continuous daily support through diet is required. However, even foods that contain the necessary vitamins can have reduced vitamin content after storage, processing, or cooking. Therefore, many people take a multivitamin tablet to supplement their diet. To ensure that these tablets contain the labeled amounts of vitamins, there must be a quality control assay for these tablets. [Pg.1323]

Vidovic, S., Stojanovic, B., Veljkovic, J., and Prazic-Arsic, L., 2008. Simultaneous determination of some water-soluble vitamins and preservatives in multivitamin syrup by validated stability-indicating high-performance liquid chromatography method. Journal of Chromatography A. 1202 155-162. [Pg.241]

Chen, P., Chen, B., and Yao S., 2006. High-performance liquid chromato-graphy/electrospray ionization-mass spectrometry for simultaneous determination of taurine and 10 water-soluble vitamins in multivitamin tablets. Analytica Chimica Acta. 569 169-175. [Pg.300]

Chen, P., Atkinson, R., and Wolf, W.R., 2009. Single-laboratory validation of a high-performance liquid chromatographic-diode array detector-fluorescence detector/mass spectrometric method for simultaneous determination of water-soluble vitamins in multivitamin dietary tablets. Journal of AOAC... [Pg.364]

The next generation of HPLC detectors, namely mass spectrometers, are now available and being deployed for water-soluble vitamin determinations in dietary supplements with electrospray ionization interface (ESI) (Holler et al. 2006). There remain obstacles to overcome for multivitamin analyses in complex food matrices, as co-elution of vitamins or excipients can compromise... [Pg.416]

Multivitamin preparations. Most water-soluble vitamins are polarographically active and can be determined in simple preparations without any difficulties. Difficulty is given, however, with complex multivitamin preparations. In a preparation containing in I O g (in addition to fillers) 2500 I.U. of vitamin A, 200 I.U. of vitamin D, 1 mg of vitamin Bj, T5 mg of vitamin Bg, 1 /ag of vitamin B 2> mg of pteroylglutamic acid, 0-5 mg of calcium pantothenate, 10 mg of niacinamide, 37-5 mg of vitamin C, 1 mg of vitamins E and 0-2 mg of vitamins K, the analyses were carried... [Pg.189]

TLC can be used to differentiate riboflavin from FMN (flavin mononucleotide) and some flavin analogs using various mobile phases riboflavin phosphates can be separated from riboflavin biphosphates, whereas the isomeric riboflavin phosphates co-migrate in all chromatographic systems studied (Nielsen et al., 1986). Bhushan and AH (1987) used TLC to analyze riboflavin in different matrices and also to separate and identify vitamin B2 from other water-soluble vitamins (Bi, Bj, and B12). Thielemann (1974) used TLC to separate and identify vitamin B2 from fat-soluble vitamins (A, Di, and E) in multivitamin preparations. [Pg.384]

Bhushan and Ali (1987) used TLC to separate vitamin B from the other water-soluble vitamins in multivitamin preparations they used silica gel plates... [Pg.384]

Nuttall and Bush (1971) analyzed biotin in multivitamin preparations. The fat-soluble vitamins were first extracted, and the water-soluble materials were separated in three TLC systems biotin was resolved using the mobile phase acetone-acetic acid-benzene-methanol (1 1 14 4) and detected by spraying the plate with o-toluidine-potassium iodide. Groningsson and Jansson (1979) determined biotin in the presence of other water-soluble vitamins using silica gel TLC and the mobile phase chloroform-methanol-formic acid (70 40 2) detection was by spraying with p-DACA. [Pg.385]

A separation of vitamin A from other vitamins is described by Thielemann (16,17). On silica plates eluted with a mixture of benzene-petroleum ether-acetic acid (35 65 1, by vol) vitamin A (Rf = 0.71), was separated from other lipophilic vitamins such as D2 and E (Revalues 0.18 and 0.7, respectively). Under these conditions, the water-soluble vitamins present in the multivitamin preparation remained at the origin. [Pg.1057]

Reversed-phase HPLC systems are often used for the simultaneous assay of thiamine and other water-soluble vitamins in multivitamin preparations. No special treatment of the sample is required before chromatography and UV detection at 270 nm or 254 nm is usually employed. [Pg.381]

A simultaneous detection of all water-soluble vitamins in multivitamin solution by only one TLC analysis was described by Postaire et al. in 1991 (31). The method used HPTLC plates with silica gel as stationary phase and n-butanol/ pyridine/water (50 35 15, v/v) as mobile phase. The quantitation was carried out by photodensitometric detection without derivatization (B, B2, Bg, C, folic acid, nicotinamide) or after spraying ninhydrin reagent (calcium panthothenate) or 4-dimethylaminocinnamaldehyde (B12, biotin). The use of an over-pressured layer chromatograph improved the resolution of the HPTLC plates. Good reproducibility, satisfactory standard deviations, and recoveries were obtained for all the vitamins. [Pg.409]

Riboflavin is an ingredient of many pharmaceutical multivitamin preparations. Methods have been described for the determination of riboflavin and other, water-soluble vitamins (Bj, B, B12, niacin, niacinamide, folic acid, ascorbic acid). For... [Pg.412]

The simultaneous determination of the B vitamins, thiamine, riboflavin, pyridoxal, pyridoxine, and pyridoxamine in a pharmaceutical product using CZE was described by Huopalahti and Sunell (90). Hydrochlorid acid was used for the extraction of the vitamins from the multivitamin-multimineral tablet. The applied potential was 6.0 kV, and a 75-p.m fused-silica capillary tubing was used. The electrolyte used was a 20-mM sodium phosphate buffer pH 9.0. A clear separation of standards as well as of the pharmaceutical sample is shown in Figure 14. This method appears to be a fast and simple technique for the simultaneous determination of water-soluble vitamins in pharmaceutical products, where the... [Pg.434]

Pantothenic acid/calcium pantothenate in pharmaceutical products and vitamin premixes was also analyzed using low-wavelength ultraviolet (UV) detection (64,66). The vitamin was extracted from tablets or powdered premixes with 0.005 M NaH2P04 buffer (pH 4.5) and separated from other water-soluble vitamins on an aminopropyl-bonded silica column (LiChrosorb NH2) eluted with an acetonitrile-0.005 MNaH2P04 buffer (pH 4.5) (87 13, v/v) and detected at 210 nm. Quantitative recoveries (>95%) and relative standard deviations 0.79% to 2.2% were obtained for multivitamin tablets, vitamin premixes, fortified yeasts, and raw materials. The limit of sensitivity was approximately 1 mg/g sample. The results were compared with those obtained by the standard microbiological procedure. Low levels of calcium pantothenate (<3 mg per tablet) were more precisely analyzed by the HPLC procedure than by the microbiological method. [Pg.575]

Gennaro (51) proposed a method for the separation of water-soluble vitamins by means of the ion interaction reagent using octylamine < -phosphate or octylamine salicylate buffer (at pH 6.4) as the interaction reagent and the mobile phase at a flow rate of 1 mL/min, and a 2.5-p.m Spherisorb ODS C18 column (250 X 4.6 mm) as the stationary phase. The column effluent was monitored at 210 nm. Retention times of pantothenic acid obtained with octylamine t)-phos-phate and octylamine salicylate were 64.0 and 9.8 min. The method was used for the determination of pantothenic acid in a model mixture of water-soluble vitamins and also in a commercial multivitamin isotonic salt dietetic drink (Fig. 9). [Pg.576]

The key step of a multivitamin method is the development of a simultaneous and quantitative extraction procedure. The intra- and intergroup heterogeneity of water-soluble vitamins makes it difficult to realize this goal. The application of an acid treatment, to hydrolyze the bound forms, can be used for simultaneous extraction of Bi, B2, B3, Bg, Bs,... [Pg.497]


See other pages where Water-soluble vitamin multivitamin is mentioned: [Pg.35]    [Pg.420]    [Pg.423]    [Pg.272]    [Pg.596]    [Pg.60]    [Pg.4922]    [Pg.4924]    [Pg.294]    [Pg.400]    [Pg.537]    [Pg.500]   


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Water-soluble vitamins multivitamin determination

Water-soluble vitamins vitamin

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