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Electrospray ionization with

Cui, M., Song, F., Liu, Z., and Liu, S. (2001). Metal ion adducts in the structural analysis of ginsenosides by electrospray ionization with multi-stage mass spectrometry. Rapid Commun. Mass Spectrom. 15, 586-595. [Pg.83]

N. J. Haskins, C. Eckers, A. J. Organ, M. F. Dunk and B. E. Winger, The use of electrospray ionization with Fourier transform ion cyclotron resonance mass spectrometry in the analysis of trace impurities in a drag substance. Rapid Communications in Mass Spectrometry, 1995,9(11), 1027-1030. [Pg.120]

Electrospray ionization with the high resolving power of Fourier transform mass spectrometry (FTMS) makes possible the detection of adducts and subpicomole impurities that confuse lower resolution measurements, as shown in Figure 8.30. This method achieves accurate determination of molecular weights (<0.002 %) and permits the verification of 50-100-mer DNA and RNA sequences. [169,170]... [Pg.346]

Fig. 7A-D. SFC/ELSD/CLND/MS analysis of an equimolar mixture of Tolbutamide, Fmoc-Ile-OH, Mebendazole, and Prednisolone. The column flow rate was 5 ml/min. A portion of the column effluent was split to each of the three detectors (CLND, 200 pl/min ELSD,200 pl/min MS, 100 pl/min). A makeup flow of 50/50 MeOH/H20 (300 pl/min) was added to the flow stream diverted to the mass spectrometer ion source. Mass spectra were acquired using electrospray ionization with no special modifications to the ion source A total ion current chromatogram showing two of the four components ionize efficiently under electrospray ionization conditions B ELSD chromatogram of the four components, all showing comparable response C UV chromatogram (254 nm) shows some selectivity in detection as does D D CLND detection. Reprinted from [7] with permission from D.B. Kassel... Fig. 7A-D. SFC/ELSD/CLND/MS analysis of an equimolar mixture of Tolbutamide, Fmoc-Ile-OH, Mebendazole, and Prednisolone. The column flow rate was 5 ml/min. A portion of the column effluent was split to each of the three detectors (CLND, 200 pl/min ELSD,200 pl/min MS, 100 pl/min). A makeup flow of 50/50 MeOH/H20 (300 pl/min) was added to the flow stream diverted to the mass spectrometer ion source. Mass spectra were acquired using electrospray ionization with no special modifications to the ion source A total ion current chromatogram showing two of the four components ionize efficiently under electrospray ionization conditions B ELSD chromatogram of the four components, all showing comparable response C UV chromatogram (254 nm) shows some selectivity in detection as does D D CLND detection. Reprinted from [7] with permission from D.B. Kassel...
P Dobberstein, E Schroder. Accurate mass determination of a high molecular weight protein using electrospray ionization with a magnetic sector instrument. Rapid Commun Mass Spectrom 7 861, 1993. [Pg.195]

Sulfatides (3-sulfogalactosylceramides) were initially detected by mass spectrometry using FAB ionization but spectrum showed a number of fragmentations which complicates considerably the method (Ohashi and Nagai, 1991). More recently structural characterization of sulfatides by collisional-activated dissociation (CAD) was described in quadrupole ion-trap tandem mass spectro-metric methods with electrospray ionization. With the method [M - H]- ions of sulfatides yield abundant structurally informative ions that permit unequivocal assignments of the long-chain base and fatty acid constituent including the location of double bond (Hsu and Turk, 2004). The major sulfatide molecular species are quantified similarly in the 2 clinical forms (motor and... [Pg.578]

John Fenn is generally credited for first developing the application of electrospray ionization with mass spectrometry (Fenn et al, 1989). Electrospray ionization is an atmospheric pressure ionization technique, in contrast to MALDl, which is normally carried out in vacuo. When used for mass spectrometry, atmospheric pressure ionization involves ionization at pressure, solvent removal and charge transfer to analyte molecules, and then introduction into the mass spectrometer via some sort of ion guide system. In electrospray ionization, the liquid... [Pg.60]

Myung, S., Wiseman, J.M., Valentine, S.J., Takats, Z., Cooks, R.G., Clemmer, D.E., Coupling desorption electrospray ionization with ion mohihty/mass spectrometry for analysis of protein structure evidence for desorption of folded and denatured states. J. Phys. Chem. B 2006,110, 5045. [Pg.123]

Williams, J.P. Scrivens, J.H. Coupling desorption electrospray ionization and neutral desorption/extractive electrospray ionization with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs. Rapid Commun. Mass Spectrom. 2008, 22, 187-196. [Pg.233]

Ge, X., Sirich, T.L., Beyer, M.K., Desaire, H., Leary, J.A. (2001) A Strategy for the Determination of Enzyme Kinetics Using Electrospray Ionization with an Ion Trap Mass Spectrometer. Anal. Chem. 73 5078-5082. [Pg.143]

Sun F, He Q, Shi P, Xiao P, Cheng Y (2007) Characterization and identification of triterptaioid saponins in crude extracts from Clematis spp. by high-performance liquid chromatography/ electrospray ionization with multi-stage tandem mass spectrometry. Rapid Commun Mass Spectrom 21 3743-3750... [Pg.4084]

Hsu FF, Turk J. Electrospray ionization with low-energy collisionally activated dissociation tandem mass spectrometry of glycerophospholipids mechanisms of fragmentation and structural characterization. J Chromatogr B. 2009 877 2673-95. [Pg.116]

Murray KK. DNA sequencing by mass spectrometry. J Mass Spectrom. 1996 31 1203-15. Xiang Y, Abliz Z, Takayama M. Cleavage reactions of the complex ions derived from self-complementary deoxydinucleotides and alkali-metal ions using positive ion electrospray ionization with tandem mass spectrometry. J Am Soc Mass Spectrom. 2004 15 689-96. Boschenok J, Sheil MM. Electrospray tandem mass spectrometry of nucleotides. Rapid CommunMass Spectrom. 1996 10 144-9. [Pg.261]

Advances in mass spectrometry have made it a tool of exceptional power for analysis of large biomolecules. Electrospray ionization, MALDI, and other soft ionization techniques for nonvolatile compounds and macromolecules make possible analyses of proteins, nucleic acids, and other biologically relevant compounds with molecular weights up to and in excess of 100,000 daltons. Electrospray ionization with quadrupole mass analysis is now routine for biomolecule analysis as is analysis using MALDI-TOF instruments. Extremely high resolution can be achieved using Fourier transform-ion cyclotron resonance (FT ICR, or FTMS). We shall discuss ESI and MALDI applications of mass spectrometry to protein sequencing and analysis in Sections 24.5E, 24.13B, and 24.14. [Pg.443]

Hsu, E.-E. and Turk, J. (2005) Electrospray ionization with low-energy collisionally activated dissociation tandem mass spectrometry of complex lipids Structural characterization and mechaiusm of fragmentation. In Modern Methods for Lipid Analysis by Liquid Chromatography/Mass Spectrometry and Related Techiuques (Byrdwell, W.C., ed.). pp. 61-178, AOCS Press, Champaign, IL. [Pg.171]

Many metabolites are polar, ionic, and nonvolatile. Thus comprehensive metabolic analysis is not well suited for gas chromatographic techniques. Metabolite mixtures in complex biological samples such as lymph and blood, however, can be rapidly characterized by electrospray ionization with ion mobility coupled to mass spectrometry. As with GC-IMS, coupling ion mobility spectrometers with mass spectrometers produces two dimensions of information. There are many types of ion mobility-mass spectrometers (IM-MS) and most of these will be discussed in other chapters of this book. The focus of this chapter, however, is on atmospheric pressure IMS with quadrupole or time-of-flight mass spectrometry. Other types of IM-MS have also been recently been reviewed. Advantages of coupling atmospheric pressure IMS with a mass spectrometer include ... [Pg.244]

Dobberstein, P. Schroeder, E. Accurate Mass Determination of a High Molecular Weight Protein Using Electrospray Ionization with a Magnetic Sector Instrument. Rapid Commun. Mass Spectrom, 1993, 7, 861-864. [Pg.617]

Hsu, RR, Turk, J., Rhoades, E.R., Russell, D.G., Shi, Y.X. and Groisman, E.A., Structural characterization of cardiohpin by tandem quadrupole and mulhple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. J. Am. Soc. Mass Spectrom., 16, 491-504 (2005). Hsu, RR and Turk, J., Characterization of cardiohpin from Escherichia coli by electrospray ionization with multiple stage quadrupole ion-trap mass spectrometric analysis of [M — 2H -I Na](—) ions. J. Am. Soc, Mass Spectrom., 17, 420-429 (2006). [Pg.244]

Nischwitz V, Michalke B (2009) Electrospray ionization with selected reaction monitoring for the determination of Mn-citrate, Fe-citrate, Cu-citrate and Zn-citrate. Rapid Comm... [Pg.260]

Jackson, G. S. Enke, C. G. Electtical equivalence of electrospray ionization with conducting and... [Pg.118]


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Electrospray ionization

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