Combination products

Figure Bl.16.9. Background-free, pseudo-steady-state CIDNP spectra observed in the photoreaction of triethylamine with different sensitizers ((a), antliraquinone (b), xanthone, CIDNP net effect (c), xanthone, CIDNP multiplet effect, amplitudes multiplied by 1.75 relative to the centre trace) in acetonitrile-d3. The stmctiiral formulae of the most important products bearing polarizations (1, regenerated starting material 2, N,N-diethylvinylamine 3, combination product of amine and sensitizer) are given at the top R denotes the sensitizer moiety. The polarized resonances of these products are assigned in the spectra. Reprinted from [21].

Phenylmagnesium bromide (2.8 mol) was prepared in anhydrous ether (21) from bromobenzene (440 g, 2.9 mol) and magnesium turnings (68.0 g 2.8 g-atom). To this solution was added dropwise a solution of indole (328 g, 2.8 mol) in benzene (8(X)ml). The resulting solution was stirred for 10 min and then a solution of cyclopentanoyl chloride (322 g, 2.4 mol) in benzene (800 ml) was added dropwise. The solution was stirred for 1 h and then water (11) was added carefully. The precipitate which formed was collected by filtration and dried to give 169 g of crude product. Additional product (97 g) was obtained by evaporation of the organic layer of the filtrate. The combined products were recrystallized from toluene to give 250 g (49% yield) of pure product. 

Dissipation studies for combination products and tank mix uses... 

Second PCR combine products above denaturation, annealing of complementary strands... 

Although soybeans contribute about one-half of the world production of oilseeds, they supply less than one-third of the total edible vegetable fats and oils (Table 11) because of their relatively low oil content. Nonetheless, production of soybean oil exceeds the combined production of cottonseed, peanut, and sunflower seed oils. 

Animal uses employ resin in various stabilized forms at levels of 200,000 400,000 500,000 and 1 x 10 units of per gram. Combination products containing A and D are also available, with 650,000 units of vitamin A and 325,000 units vitamin D per gram of product being the most common dosage form. 

Sulbactam (25, R = R = H, R" = R " = dl ) is produced by Pfizer. The oral version of sulbactam in combination with ampicillin is called Unasyn Oral which is the mutual prodmg sultamicillin. Two sulbactam parenteral products are sold, a combination product with ampicillin called Unasyn and a combination with cefoperazone [62893-19-0] called Sulperazon. In addition, sulbactam is sold alone for parenteral use with any P-lactam antibiotic as Betamaze. In 1990 worldwide sales of sulbactam containing products were over 280 million. 

Dried product is collected in either cyclones or baghouses depending upon the product-particle size. When primary coUection is carried out in cyclones, secondary collection in a baghouse or scrubber is usually necessary in order to comply with environmental regulations. A rotary valve is used to provide an airlock at the discharge point. Screws are utihzed to combine product from multiple cyclones or large bag-houses. If required, a portion of the dried product is separated from the main stream and returned to the feed system for use as backmix. 

The combined product is mixed with i 1. of 20 per cent sodium hydroxide solution and stirred on the steam bath for four hours, in order to hydrolyze a small proportion of heptyl acetate. The oil is then separated and distilled, and the portion boiling at 172-176° collected. The residue in the flask is mixed with about 100 cc. of water and distilled, whereupon a further small quantity of oil passes over with the steam. This distillate and the forerun are freed of the bulk of the water in a separatory funnel, and distilled from a smaller flask. In this way the total yield of -heptyl alcohol boiling at 172-176° (uncorr.) is 350-370 g. (75-81 per cent of the theoretical amount). The alcohol may be redistilled under reduced pressure, and it passes over almost without loss at 7i-72°/i2 mm. 

This can be viewed as optimization of the pharmacotherapeutic profile and therefore is treated as a fixed combination product, for which a separate note for guidance... 

On evaporating the alcoholic solution under reduced pressure from a water bath held at 50-60° (Note 6) the residue weighs about 540 g. A mixture of 600 cc. of absolute alcohol and 10 cc. of concentrated sulfuric acid (Note 7) is then added. The mixture is then heated on the water bath under a reflux condenser for three hours. The excess of alcohol and some of the water formed are removed by distillation under reduced pressure and the residue again heated for two hours with 300 cc. of absolute alcohol and an additional 4 cc. of concentrated sulfuric acid. The alcohol is removed by distillation under reduced pressure, and when the ester has cooled to room temperature, the sulfuric acid is neutralized with a concentrated solution of sodium carbonate the ester (upper layer) is separated, and the aqueous solution extracted with ether, or preferably benzene about one-tenth of the yield is in the extract. The combined products are placed in a i-l. distilling flask and distilled under reduced pressure after the solvent and alcohol and water have been removed. The ester is collected at 94-990, chiefly at 97-98°/x6 mm. (Note 8). The yield of a product analyzing about 97-98 per cent ethyl cyanoacetate amounts to 474-492 g. (77-80 per cent of the theoretical amount) (Note 9). 

It has been suggested that benzylic radicals may form a dimeric association complex which may easily collapse to the combination product but be geometrically unfavorable for disproportionation.1,8-179 Even if this applies for the aralkyl radicals, it cannot account for the behavior of systems with other / -substituents. 

Even though the rate of radical-radical reaction is determined by diffusion, this docs not mean there is no selectivity in the termination step. As with small radicals (Section 2.5), self-reaction may occur by combination or disproportionation. In some cases, there are multiple pathways for combination and disproportionation. Combination involves the coupling of two radicals (Scheme 5.1). The resulting polymer chain has a molecular weight equal to the sum of the molecular weights of the reactant species. If all chains are formed from initiator-derived radicals, then the combination product will have two initiator-derived ends. Disproportionation involves the transfer of a P-hydrogen from one propagating radical to the other. This results in the formation of two polymer molecules. Both chains have one initiator-derived end. One chain has an unsaturated end, the other has a saturated end (Scheme 5.1). 

Bizilj et at reported that disproportionation is more important for oligomeric radicals. While combination products were unequivocally identified, analytical difficulties prevented a precise determination of the disproportionation products. Accordingly, they were only able to state a maximum value of ktself reaction of 11 and <1.50 for reaction between 8 and 11. 

Under particularly difficult conditions, neutralizing amines are expensive and not always totally successful. The use of satellite dosing points and programs that combine neutralizers with filmers (either fed separately or as a combination product) may produce the desired result. Proof of effectiveness requires pH and Fe/Cu/Ni mass balance profile trials to be undertaken. 

For fluidized bed reactors, special water-soluble, combustion catalyst and slag modifier combination products are available. These products are diluted and typically are fed at rates of from 20 to 60 lb per day for every 10 tons of bed extraction. 

Besides the azo coupling reactions of 1-methyl- and 2,5-dimethylpyrrole with benzenediazonium-4-sulfonate mentioned above, Butler et al. (1977) synthesized almost all possible combination products of the unsubstituted and four 4-substituted benzenediazonium ions with pyrrole itself, with most isomeric mono-, di-, and trimethyl-pyrroles, and with 3-ethyl-2,4-dimethylpyrrole. These authors also investigated the kinetics of all these combinations (see Sec. 12.7). 

Haemophilus influenzae type b (Hib) conjugate vaccine. Three Hib conjugate vaccines are licensed for infant use. If PRP-OMP (PedvaxHIB or ComVax) is administered at ages 2 and 4 months, a dose at age 6 months is not required. DTaP/Hib combination products should not be used for primary immunization in infants at ages 2, 4 or 6 months, but can be used as boosters following any Hib vaccine. 

An EU application for a combination product that contains previously authorised active substances must be supported by appropriate safety and efficacy data for the combination. However, there is no need to submit data on the safety and efficacy of the components individually. The combination product is considered a unique product distinct from the authorisations granted to the individual ingredients, and will thus have a separate exclusivity clock running from the date when the combination was authorised. 

In 2002, the world production of polymers (not including synthetic libers and rubbers) was ca. 190 million metric tons. Of these, the combined production of poly(ethylene terephthalate), low- and high-density polyethyelene, polypropylene, poly(vinyl chloride), polystyrene, and polyurethane was 152.3 milhon metric tons [1]. These synthetic, petroleum-based polymers are used, inter alia, as engineering plastics, for packing, in the construction-, car-, truck- and food-industry. They are chemically very stable, and can be processed by injection molding, and by extrusion from the melt in a variety of forms. These attractive features, however, are associated with two main problems ... 

There is an additional problem that must be considered for radicals that escape an original geminate radical pair. Such radicals are polarized. If they form new (encounter) radical pairs, they could yield combination products after undergoing T-S mixing again. However, because of the rapidity of nuclear relaxation in free radicals, the F-type polarization generally predominates. 

Dependence on barbiturates has declined in recent years as physicians have substituted benzodiazepines for the treatment of many of the conditions for which barbiturates were formerly used. Clinicians will still see cases of abuse and dependence among medical patients receiving barbiturates or barbirurate combination products (e.g., Fiorinal) and in substance abusers (Silberstein and McCrory 2001). 

Butalbital Many combination products (e.g., Esgic, Fioricet, Fipricet with Codeine, and Fiorinal with Codeine)... 

Production, Import/Export, Use, Release, and Disposal. Methyl parathion is commercially produced in the United States and abroad. Since 1977, production volume statistics for methyl parathion have been combined with those of ethyl parathion, also known as parathion. In 1983, the combined production capacity was estimated at 29 million kg for the United States and 10-15 million kg for western Europe (lARC 1983). Data on recent production in the United States were not located. In 1980,... 

Listing as a hazardous waste Column bottoms or heavy ends from the combined production of PCE and TCE Yes EPA1981d(40CFR 261.32) EPA 1981e... 

---