Vascular aging

Paterniti S, Dufouil C, Alperovitch A. Long-term benzodiazepine use and cognitive decline in the elderly the epidemiology of vascular aging study. J Clin Psychopharmacol 2002 22(3) 285-93. 

Rasmussen H, Chu K, Campochiaro P, et al. Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF. 11D (ADPEDF) in neo-vascular age-related macular degeneration (AMD). Hum Gene Ther 2001 12 2029-2032. 

Bone marrow cells have the potential to give rise to vascular progenitor cells that hone in on damaged vessels and differentiate into SMC and EC (255) However, progressive progenitor cell deficits, the effect of concomitant vascular aging, may contribute to the development of atherosclerosis (256), because the age-dependent failure of the bone marrow to produce vascular progenitor cells responsible for arterial repair drives atherosclerosis and its thromboembolic complications (reviewed in ref. 257). 

Kunz J. Initial lesions of vascular aging disease (arteriosclerosis). Gerontology 2000 46 295-299. 

SUva R, Axer-Siegel R, Eldem B, Guymer R, Kirchhof B, Papp A, et al. The SECURE study long-term safety of ranibizumab 0.5 mg in neo-vascular age-related macular degeneration. Ophthalmol 2013 120(l) 130-9. 

Ferrara N, Damico L, Shams N, et al (2006) Developmemt of Ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 26 859-870... 

In the peel strong immunological depositions of acetyl esterase were found in epidermis, the small cells of the exocarp and in the oil cavities (Fig. 3 A,B,C). In the mesocarp and endocarp the immunological depositions were more moderate (Fig. 3 D), but strong immunological depositions were found in the vascular bundles, especially in xylem. The immunological depositions in the peel seem to be correlated with cell size or cell age. The small cytoplasma rich cells have a higher content of acetyl esterase. 

Routine antioxidant vitamin supplementation, e.g. with vitamins C and/or E, of the diabetic diet should be considered. Vitamin C depletion is present in all diabetics irrespective of the presence of vascular disease. A recent study demonstrated no significant difference between the dietary intake of vitamin C (the main determinant of plasma ascorbate) in patients with diabetes and age-matched controls, confirming the view that ascorbate depletion is secondary to the diabetic process and su esting that diabetic patients require additional intakes of the vitamin to maintain optimal levels (Sinclair et /., 1994). Antioxidant supplementation may have additive beneficial effects on a wide variety of processes involved in diabetic vascular damage including blood pressure, immune function, inflammatory reactions. 

Kirstein, M., Brett, J., RadoflT, S., Ogawa, S., Stem, D. and Vlassara, H. (1990). Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth fector role in vascular disease of diabetes and aging. Proc. Natl Acad. Sci. USA 87, 9010-9014. 

Cyclosporine and tacrolimus are calcineurin inhibitors that are administered as part of immunosuppressive regimens in kidney, liver, heart, lung, and bone marrow transplant recipients. In addition, they are used in autoimmune disorders such as psoriasis and multiple sclerosis. The pathophysiologic mechanism for ARF is renal vascular vasoconstriction.41 It often occurs within the first 6 to 12 months of treatment, and can be reversible with dose reduction or drug discontinuation. Risk factors include high dose, elevated trough blood concentrations, increased age, and concomitant therapy with other nephrotoxic drugs.41 Cyclosporine and tacrolimus are extensively metabolized by... 

Psychotic symptoms in late life (greater than 65 years of age) are generally a result of an ongoing chronic illness carried over from younger life however, a small percentage of patients develop psychotic symptoms de novo, defined as late-life schizophrenia. The 6-month prevalence rate of schizophrenia in the elderly is around 1%. However, other illnesses presenting with psychotic symptoms are common in this population, as approximately one-third of patients with Alzheimer s disease, Parkinson s disease, and vascular dementia experience psychotic symptoms. The majority of data for antipsychotic use in the elderly comes from experience treating these other disease states. 

Penile disease (Peyronie s disease or anatomic abnormalities) Surgical Procedures Perineal surgery Radical prostatectomy Vascular surgery Lifestyle Age... 

I NF can affect any age group. Although the risk of NF is higher in patients with underlying diseases (specifically diabetes, alcoholism, cardiac disease, and peripheral vascular disease), healthy hosts can become infected as well.20... 

Low risk Node-negative and all the following pathologic tumor size of 2 cm or less, or grade 1, absence of peritu-moral vascular invasion, HER2/neu gene neither overexpressed nor amplified, and age 35 years or older... 

Another prominent site of deposition of (5-amyloid fibrils with age and in AD is within the cerebrovasculature in areas of the brain prone to parenchymal amyloid deposition [137-139]. The peptide deposits along the surfaces of the smooth muscle cells of the vascular wall, resulting in the death of those cells and their replacement by amyloid fibrils, weakening the vascular wall. Endothelial cells are also affected [140]. The Dutch mutation in the APP precursor protein Q22E, within the (5-peptide sequence, produces a particularly fibrillogenic and toxic (to smooth muscle cells) peptide associated with primarily vascular deposition of mutant peptide and hemorrhagic vessel disease [137]. Thus, in addition to neuronal cells, the brain vascular smooth muscle cells are a pathologically relevant cell type. While the source of... 

One more example of acute polychlorpinen poisoning occurred in the Ukraine around 1969-70, when 27 women aged 26-49 were sent out to sow collective farm fields three days after the fields had been treated with polychlorpinen. A warm rain washed the pesticide from the soil, and the pesticide evaporated intensively. All the women showed symptoms of acute poisoning 20-40 minutes later eight lost consciousness, and nine had fits. The poisoned women spent from 3-25 days in the regional hospital, after which they all went to the VNIIGINTOKS clinic with disruptions of the neural and cardio-vascular systems, as well as of the digestive tract over the next 9-13 months [43]. 

Compound (32) is currently being developed for the clinical treatment of cancer, of atherosclerotic vascular disease, and of age-related macular degeneration, all of which are PDT applications.132,133 Photodiagnostic applications also appear to be in view.141... 

M. Nordstrom and T. Kjellstrom, Age dependency of cystathione beta-synthase activity in human fibroblasts in homocysteinemia and atherosclerotic vascular disease. Atherosclerosis 94, 213-221 (1992). 

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