Fragment antigen-binding

Ferrara N, Damico L, Shams N, et al (2006) Developmemt of Ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 26 859-870... 

As depicted in Figure 50-8, digestion of an immunoglobulin by the enzyme papain produces two antigen-binding fragments (Fab) and one crystallizable fragment (Fc), which is responsible for functions of im-... 

FAB Fast-electron bombardment Fab Antigen binding fragment F(ab )2 Fragment of an immunoglobulin produced pepsin treatment... 

Figure 1.77 Disulfide reducing agents such as 2-mercaptoethylamine can be used to cleave the disulfide bonds in the hinge region of antibody molecules. Either intact IgG molecules or F(ab )2 fragments may be reduced in this manner to yield monofunctional antigen binding fragments.

Antigen-Binding Fragments (Fab), Fab, and F(ab )2- Various parts that contain the variable fragment. 

Electronic Standards for Transmission of Regulatory Information European Union antigen-binding fragment fluorescence-activated cell sorter fetal bovine serum constant fragment... 

Phage infection of bacteria containing inserted genes encoding antigen-binding fragments... 

Fab, the antigen-binding fragments. Each branch has a single antigen-binding site. 

Fig. 4-8 Stylized representations of protein structures in which a helices are represented as coiled ribbons and p strands are represented by arrows pointing in the N — C direction, p proteins contain predominantly /3-sheet structure (e.g., retinol binding protein and the antigen binding fragment of antibodies) while a proteins contain predominantly a helices (e.g., myoglobin), alp proteins contain a mixture of a helix and p sheet (e.g., triosephosphate isomerase).

Incorporation of (111) into a kinetically stable complex suitable for attachment to an antibody calls for an octadentate ligand, and so pendant-arm cyclen derivatives are appropriate. In particular, two or three antigen-binding fragments of an antibody (Fabs) have been attached to the di- or trimaleimide ligands 80-82 (Scheme 8) (90, 91)... 

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