Tumor pathology

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Trout have thus become adopted and established as a model of carcinogenesis for a number of reasons. In summary, they (i) have low rearing costs compared to rodents, (ii) provide a highly sensitive early life-stage bioassay, (iii) are sensitive to a wide variety of carcinogens, (iv) are responsive to promoters and inhibitors, (v) have a well-defined tumor pathology, (vi) are mechanistically comparable to mammalian models and (vii) provide more tissues for analysis compared with smaller aquarium fish. 

Vimentin is a 57-kD protein that was initially isolated from a mouse fibroblast culture7>" Its name derives from the Latin vimentum, describing an array of flexible rods. This IFP is considered to be the primordial member of the intermediate filament family, because it is present in most, if not all, fetal cells early in development. Moreover, when two or more IFPs are coexpressed by a cell line or neoplasm, vimentin is virtually always one of them." Accordingly, vimentin is not considered to be cell type-specific. From the perspective of mesenchymal tumor pathology, it is of interest that vimentin shows... 

One of the greatest challenges in the realm of bone and soft tissue tumor pathology is the reliable recognition of osseous matrix production in malignant... 

There are several other determinants that often figure into differential diagnosis in the sphere of soft tissue and bone tumor pathology. They include melanocyte-related markers such as melan-A (MART-1), tyrosinase, and neuroendocrine and... 

Sloane JP, Ormerod MG. Distribution of epithelial membrane antigen in normal and neoplastic tissues and its value in diagnostic tumor pathology. Cancer. 1981 47 1786-1795. 

Busam KJ. The use and application of special techniques in assessing melanocytic tumors. Pathology. 2004 36 462-469. 

Burger PC, Scheithauer BW. Atlas of Tumor Pathology Tumors of the Central Nervous System. Series 4. Washington, D.C ... 

Solcia E, Capella C, Kloppel G. Atlas of Tumor Pathology Tumors of the Pancreas. Washington, DC Armed Forces Institute of Pathology 1997. 

Shimosato Y, Mukai K. Tumors of the mediastinum. In Rosai J, ed. Atlas of Tumor Pathology, Series 3, Fascicle 21. Washington, DG Armed Eorces Institute of Pathology 1997 33-273. 

DeLeij L, Broers J, Ramaekers F, et al. Monoclonal antibodies in clinical and experimental pathology of lung cancer. In Roiter DJ, Fleuren GJ, Warner SO, eds. Applications of Monoclonal Antibodies in Tumor Pathology. Dordrecht Martinus Nijhoff 1987 191-210. 

Pignatelli M, Vessey CJ. Adhesion molectrles novel molectrlar tools in tumor pathology. Hum Pathol. 1994 25 849-856. 

Heitz PU, Komminoth P, Perren A. Pancreatic endocrine tumors Introduction. In Delellis RA, Lloyd RV, Heitz PU, Eng C, eds. WHO Classification of Tumors. Pathology and Genetics of Tumours od Endocrine Organs. Lyon, France lARC Press 2004 177-182. 

Sibony M, Vieillefond A. Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology. Ann Pathol. 2008 28 381. 

Ulbright TM. The most common, clinically significant misdiagnoses in testicular tumor pathology, and how to avoid them. Adv Anat Pathol. 2008 15 18. 

Joshi W. Peripheral neuroblastic tumors pathologic classification based on recommendations of international neuroblastoma pathology committee (modification of Shimada classification). Pediatr Dev Pathol. 2000 3 184-199. 

Pimentel J, Resende M, Vaz A, et al. Rosette-forming glioneuronal tumor Pathology case report. Neurosurgery. 2008 62 E1162-E1163. 

Cochran AJ, Wen DR. S-100 protein as a marker for melano-cytic and other tumors. Pathology. 1985 17 340-345. 

Laszlo Krenacs Laboratory of Tumor Pathology and Molecular Diagnostics,... 

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