Small intestinal submucosa

Le Visage C et al (2006) Small intestinal submucosa as a potential bioscaffold for intervertebral disc regeneration. Spine 31(21) 2423-2430, discussion 2431... 

Synthetic polymers (polyvinyl alcohol, polylactic acid,) are very popular due to their higher stability and lower price, but the biocompatible natural polymers are more and more applied, as well as cellular tissue matrices (e.g., bladder submucosa and small intestinal submucosa). 

T.W. Gilbert, A.M. Stewart-Akers, A. Simmons-Byrd, S.F. Badylak, Degradation and remodeling of small intestinal submucosa in canine Achilles tendon repair, J. Bone Jt. Surg. 89 (2007) 621-630. 

S. Wu, Y. Liu, S. Bharadwaj, A. Atala, Y. Zhang, Human urine-derived stem cells seeded in a modified 3D porous small intestinal submucosa scaffold for urethral tissue engineering. Biomaterials 32 (5) (2011) 1317-1326. 

SIS (small intestinal submucosa) Decellularized extracellular matrix Surgery, tissue engineering... 

Kim, S.H., Song, J.E., Lee, D., Khang, G. Development of poly(lactide-co-glycolide) scaffold-impregnated small intestinal submucosa with pores that stimulate extracellular matrix production in disc regeneration. J. Tissue Eng. Regen. Med. 8(4), 279-290 (2014)... 

Le Visage, C., Yang, S.H., Kadakia, L., Sieber, A.N., Kostuik, J.P., Leong, K.W. Small intestinal submucosa as a potential bioscaffold for intervertebral disc regeneration. Spine(PhilaPa 1976)31(21), 2423-2430 (2006)... 

H. B., Khang, G. The characterization of PLGA/small intestinal submucosa composites as scaffolds for intervertebral disc. Key Eng. Mater. 342-343,112-116 (2007)... 

Given the diversity of potential tissue sources, it may come as a surprise that the number of source tissues used in current soft tissue repair products is quite limited. The vast majority of products in the maricetplace are manufactured using demtis, the innermost layers of the skin, or pericardium, the thin fibrous sac surrounding the heart other sources include porcine small intestinal submucosa and human fascia lata. The number of species from which tissues are harvested is also limited. Dennis is obtained predominately from hnman, porcine, and bovine somces. Pericardium is conunonly from bovine, porcine, and equine sources. Recently, a new product has been approved in the United States and the European Union for use in wounds that is made from fish dermis" and another made from decellularized porcine liver (MiroMesh, MhoMatrix, Inc.) has been approved for use in soft tissue repair. 

Human cadaveric dermis (AlloDerm ) has been used in a variety of neurosurgical procedures. In a prospective multicenter study by Bejjani et al., ° porcine small intestinal submucosa (SIS) was used to replace dura matter resected during neurosurgery in 59 patients 18 of the patients underwent tumor resection and 32 patients underwent decompression of a Type I Chiari malformation. A water-tight seal was achieved in all 59 cases interoperatively. Mean follow-up was 7.3 months and both CSF leak rate (1.7%) and wound infection rate (3.4%) were comparable to rates reported in the literature for other materials in dural repair. There were no adverse reactions to the graft and SIS was deemed by the authors to be suitable for use in dural repair. 

Helton WS, Fisichella PM, Berger R, Horgan S, Espat Nl, Abcarian H. Short-term outcomes with small intestinal submucosa for ventral abdominal hernia. Arch Surg 2005 140(6) 549-62. 

Bejjani GK, Zabramski J. Safety and efficacy of the porcine small intestinal submucosa dural substitute results of a prospective multicenter study and literature review. J Neurosurg 2007 106(6) 1028-33. 

Jiang T, Wang G, Qiu J, Luo L, Zhang G (2009) Heparinized poly(vinyl alcohol)-small intestinal submucosa composite membrane for coronary covered stents. Biomed Mater 4 025012... 

Lantz GC, Badylak SF, Hiles MC, Coffey AC, Geddes LA, Kokini K, Sandusky GE, Morff RJ. Small intestinal submucosa as a vascular graft a review./. Invest. 5 wrg. 6 297-310,1993. 

Badylak SF, Record R,Lindberg K,Hodde J, Park K. Small intestinal submucosa a substrate for in-vitro cell growth. J. Biomater. ScL Polym. Ed. 9 863-878,1998. 

Finally, some TE applications take advantage of naturally derived bioactive scaffolds such as cadaver- or animal-derived deceUularized ECM products (eg, the product from porcine small intestinal submucosa. Oasis Wound Matrix) that have the right bioactivity to induce regeneration and are commonly used in clinical applications. 

AlloDerm, acellular dermal matrix bFGF, basic fibroblast growth factor EGF, epidermal growth factor Gelfoam, gelatin from denatured porcine skin HA, hyaluronic acid Surgisis, porcine small intestine submucosa TM, tympanic membrane UBM, urinary bladder matrix. 

Badylak, S., Kokini, K., Tullius, B., Simmons-Byrd, A., Morff, R., 2002. Morphologic study of small intestinal submucosa as a body wall repair device. J. Surg. Res. 103, 190—202. 

Badylak, S. E, G. C. Lantz, A. Coffey, and L. A. Geddes. 1989. Small intestinal submucosa as a large diameter vascular graft in the dog. / SurgRes 47 74-80. 

Kropp, B. R, B. D. Sawyer, H. E. Shannon et al. 1996b. Characterization of small intestinal submucosa regenerated canine detrusor Assessment of reinnervation, in vitro compliance and contractility. 

Mondalek, R G., R. A. Ashley, C. C. Roth et al. 2010. Enhanced angiogenesis of modified porcine small intestinal submucosa with hyaluronic acid-poly(lactide-co-glycolide) nanoparticles From fabrication to preclinical validation. /Biomed Mater Res A. 94 712-719. 

Yang, B., L. Zhou, Z. Sun et al. 2010. In vitro evaluation of the bioactive factors preserved in porcine small intestinal submucosa through cellular biological approaches. / Biomed Mater Res A... 

Zhang, Y, D. Frimberger, E. Y. Cheng, H. K. Lin, and B. P Kropp. 2006. Challenges in a larger bladder replacement with cell-seeded and unseeded small intestinal submucosa grafts in a subtotal cystectomy model. BJU Int 98 1100-1105. 

Roeder, R. et al., Comphance, elastic modulus, and burst pressure of small-intestine submucosa (SIS), small-diameter vascular grafts. /Biomed Mater Res, 1999.47(1) 65-70. 

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