Human cadaveric dermis

Human cadaveric dermis (AlloDerm ) has been used in a variety of neurosurgical procedures. In a prospective multicenter study by Bejjani et al., ° porcine small intestinal submucosa (SIS) was used to replace dura matter resected during neurosurgery in 59 patients 18 of the patients underwent tumor resection and 32 patients underwent decompression of a Type I Chiari malformation. A water-tight seal was achieved in all 59 cases interoperatively. Mean follow-up was 7.3 months and both CSF leak rate (1.7%) and wound infection rate (3.4%) were comparable to rates reported in the literature for other materials in dural repair. There were no adverse reactions to the graft and SIS was deemed by the authors to be suitable for use in dural repair. 

Human cadaveric dermis has been used by Chung et al. with an 84.2% success rate in cystocele (anterior vaginal wall) repair. In this study, 5.3% of the implants had to be removed due either to infection or to recurrence. Similarly, a study published by Lebouef et al. reports a 93.1% success rate with the use of Pelvicol (crosslinked porcine dermis). 

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