Bioactive scaffolds

Thiazolidines/thiazoles in fusion with other aromatic systems are also potential bioactive scaffolds. Riluzole (Fig. 14)—a benzothiazole analogue—is known to intervene in epilepsy, a cerebral disorder of the central nervous system, via a glutamatergic mechanism [121]. The anticonvulsant activity of riluzole has been attributed to its direct action on the voltage-dependent... 

T. Livingston, P. Ducheyne, and J. Garino, In vivo Evaluation of a Bioactive Scaffold for Bone Tissue Engineering, Journal of Biomedical Materials Research, 62(1), 1-13 (2002). 

Livingston T, Ducheyne P, Garino J. In vivo evaluation of a bioactive scaffold for bone tissue engineering. J Biomed Mater Res 2002 62(1) 1-13. 

Dankers PYW, Harmsen MC, Brouwer LA, van Luyn MJA, Meijer EW (2005) A modular and supramolecular approach to bioactive scaffolds for tissue engineering. Nat Mater 4 568-574. doi 10.1038/nmatl418... 

Although HA provides structural support and possibly promotes osteogenic differentiation, its mechanical properties are not equivalent to native bone tissue, and it is slowly invaded by host tissues when used alone as a bioactive scaffold [70-72]. To address these issues, HA nanoparticles (HANPs) can be combined with the PA nanofiber matrix, providing both the inorganic and organic components of native bone ECM, thus providing cellular behaviors that favor bone regeneration. 

Dental caries is one of the most conunon oral diseases. Unless properly treated, dental caries will progress to pulpitis, periapical infections, and ultimately result in dental loss. Dental loss can canse not only physical but also psychological suffering that compromises an individual s self-esteem and quality of life (Pihlstrom et al., 2005 Polzer et al., 2010 Jung et al., 2011 Otsu et al., 2014). Traditional therapies in current dental practice often result in the loss of tooth sensitivity and viability. Novel approaches based on tissne-derived and stem cell-derived ECM have been suggested as alternatives, along with bioactive scaffolds for dental repair. 

Tetteh G, et al. Electrospun polyurethane/hydroxyapatite bioactive scaffolds for bone tissue engineering the role of solvent and hydroxyapatite particles. J Mech Behav Biomed Mater 2014 39 95-110. 

Finally, some TE applications take advantage of naturally derived bioactive scaffolds such as cadaver- or animal-derived deceUularized ECM products (eg, the product from porcine small intestinal submucosa. Oasis Wound Matrix) that have the right bioactivity to induce regeneration and are commonly used in clinical applications. 

In microsphere sintering, pre-synthesized polymer microspheres or polymer/ceramic/bioactive addiction composites are sintered to produce a 3-D porous scaffold (56). Bioactive scaffolds can be fabricated through this technique, and they are demonstrated to be supportive to human osteoblast-like cells adhesion, growth, and mineralization (57). Scaffolds fabricated through this technique can have graded porosity structures. Mechanical properties close to cancellous bone also become possible when the microspheres are sintered into... 

Guarino, V., Causa, F., Ambrosio, L., 2007. Bioactive scaffolds for bone and ligament tissue. Expert Review of Medical Devices 4,405—418. 

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