Soft tissue repair products

Given the diversity of potential tissue sources, it may come as a surprise that the number of source tissues used in current soft tissue repair products is quite limited. The vast majority of products in the maricetplace are manufactured using demtis, the innermost layers of the skin, or pericardium, the thin fibrous sac surrounding the heart other sources include porcine small intestinal submucosa and human fascia lata. The number of species from which tissues are harvested is also limited. Dennis is obtained predominately from hnman, porcine, and bovine somces. Pericardium is conunonly from bovine, porcine, and equine sources. Recently, a new product has been approved in the United States and the European Union for use in wounds that is made from fish dermis" and another made from decellularized porcine liver (MiroMesh, MhoMatrix, Inc.) has been approved for use in soft tissue repair. 

Injectable liquid polyhydroxyalkanoate compositions consisting of the transesterification product of poly(3-hydroxyoctanoate-co-3-hydroxyhexanoate) with 1,3-butanediol were prepared by Williams et al. (3) and used in soft tissue repair, augmentation, and viscosupplementation in humans. 

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