Extracellular matrix production

Kisiday J, Jin M, Kurz B, Hung H, Semino C, Zhang S, Grodzinsky AJ. Self-assemhling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division implications for cartilage tissue repair. Proc Natl Acad Sci USA 2002 99 9996-10001. 

Davies, J. E., and Matsuda, T., Extracellular matrix production by osteoblasts on bioactive substrates in vitro. Scanning Microscopy 2,1445-1452 (1994). 

O Callaghan CJ, Williams B. Mechanical strain-induced extracellular matrix production by human vascular smooth muscle cells Role ofTGF-[i(l). Hypertension. 2000 36 319-324. 

Chang L-Y, Overby LH, Brody AR, et al. 1988. Progressive lung cell reactions and extracellular matrix production after a brief exposure to asbestos. Am J Pathol 131 156-170. 

Mann, B.K. Schmedlen, R.H. West, J.L. Tethered-TGF-P increases extracellular matrix production of vascular smooth muscle cells. Biomaterials 2001, 22, 439 44. 

Another mechanism that may contribute to TAC-induced renal fibrosis is increased IL-6 production through NF-Kappa B activation of non-lymphoid cells. Tacrolimus stimulates this inducible transcription factor, which enhances IL-6 production in fibroblasts and mesangial cells. IL-6 in turn triggers mesangial cell proliferation and extracellular matrix production [651, 766]. Inhibition of NF-Kappa B suppressed monocyte/macrophage renal infiltration and attenuated interstitial fibrosis and tubular atrophy in TAC treated rats [767, 768]. 

Restenosis after PCI is not well understood, although it is widely accepted that it is a maladaptive response to angioplasty-induced trauma, resulting in inflammation, while thrombosis, cellular proliferation (peaks at about 7 days) and extracellular matrix production (formation from 1 week onwards) [28]. 

Kim, S.H., Song, J.E., Lee, D., Khang, G. Development of poly(lactide-co-glycolide) scaffold-impregnated small intestinal submucosa with pores that stimulate extracellular matrix production in disc regeneration. J. Tissue Eng. Regen. Med. 8(4), 279-290 (2014)... 

Tutak W, Park KH, Vasilov A, Starovoytov V, Fanchini G, Cai SQ, et al. Toxicity induced enhanced extracellular matrix production in osteoblastic cells cultured on single-walled carbon nanotube networks. Nanotechnology 2009 20 255101. 

CHIQUET, M., RENEDO, A. S., HUBER, F. FLUCK, M. 2003. How do fibroblasts translate mechanical signals into changes in extracellular matrix production Matrix Biol, 22, 73-80. 

El-Amin, S.F., hu, H.H., Khan, Y., Burems, J., Mitchell, J., Tuan, R.S., and haurencin, C.T, Extracellular matrix production by human osteoblasts cultured on biodegradable polymers applicable for tissue engineering, BiomoterioZs 2003, 24(7), 1213-1221. 

Groessner-Schreiber, B. and Tuan, R.S. 1992. Enhanced extracellular matrix production and mineralization by osteoblasts cultured on titanium surfaces in vitro. J. Cell Sci. 101 209. 

FIGURE 15.1 Mechanical stimulation can affect a variety of cell responses (1) differentiation, (2) proliferation, (3) extracellular matrix production, (4) alignment, (5) migration, (6) adhesion, (7) signaling, and (8) morphology. 

Bryant, S. J., Durand, K. L., and Anseth, K. S. 2003. Manipulations in hydrogel chemistry control photo-encapsulated chondrocyte behavior and their extracellular matrix production. / Biomed Mater Res 67 A 1430-36. 

Liao, H. M., Munoz-Pinto, D., Qu, X. et al. 2008. Influence of hydrogel mechanical properties and mesh size on vocal fold fibroblast extracellular matrix production and phenotype. Acta Biomater 4 1161-71. 

Carver, S. E. and C. A. Heath 1999. Increasing extracellular matrix production in regenerating cartilage with intermittent physiological pressure. Biotechnol Bioeng 62(2) 166-74. 

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