Dermal matrix

A bilayered composite skin equivalent has been developed with a viable dermis and epidermis. The epidermis is composed from cornified differentiated keratinocytes and a dermal matrix composed of a collagen lattice containing viable fibroblasts. Its cellular components assist with wound closure through stimulation of the wound bed. The outer layer of the differentiated bilayered skin equivalent, the stratum corneum, acts as a specialized vapor permeable membrane and protective outer barrier.f ... 

Ettinger B, Pressman A. Continuation of postmenopausal hormone replacement therapy in a large health maintenance organization Trans-dermal matrix versus oral estrogen therapy. Am J Manag Care 1999 7 779-785. 

There are two basic roles for carbohydrates in the field of skin replacement. These relate to the bilaminar nature of the skin with the dermal matrix and the cellular epidermis. The matrix is a biomechanical construct and can be made. As already described, there are collagenous and noncollagenous components in the human dermis. There is and has been a considerable amount of research to explore the roles of collagen and GAG polymers in matrix production. Indeed, this is a feature of research and reviews spanning the last two decades. The most successful commercial product is Integra, which was approved for clinical use in 1996 both in the United States and Europe. 

Baldursson BT, Kjartansson H, KonrMsdottir F, Gudnason PL Sigugonsson GF, Lund SH. Healing rate and autoimmune safety of full-thickness wounds treated with fish skin acellular dermal matrix versus porcine smaU-intestine submucosa a non-inferiority study. Int J Low Extreme Wounds March 2015 14(1) 37 44. 

Chen RN, Ho HO, Tsai YT, Sheu MT. Process development of an acellular dermal matrix (ADM) for biomedical applications. Biomaterials 2004 25(13) 2679-86. 

Ge PS, Imai TA, Aboulian A. The use of human acellular dermal matrix for chest wall reconstruction. Ann Thorac Surg 2010 90 1799-804. 

Okano Y, Abe Y, Masaki H, Santhanam U, Ichihashi M, Funasaka Y (2003) Biological effects of glycolic add on dermal matrix metabolism mediated by dermal fibroblasts and epidermal keratinocytes. Exp Dermatol 12(Suppl 2) 57-63... 

Li A, Dearman BL, Crompton KE, Moore TG, Greenwood JE. Evaluation of a novel biodegradable polymer for the generation of a dermal matrix. J Bum Care Res July-August... 

Dearman BL, Li A, Greenwood JE. Optimization of a polyurethane dermal matrix and experience with a polymer-based cultured composite skin. J Bum Care Res September-October 2014 35(5) 437-48. 

Development history of NovoSorb biodegradable temporizing dermal matrix for major burn injury... 

Proof of concept of cultured composite skin on biodegradable temporizing dermal matrix... 

Long-term implantation of biodegradable temporizing dermal matrix with delayed split-skin grafting... 

The first use of biodegradable temporizing dermal matrix in moderate to severe burn repair... 

Dearman BL, Stefani K, Li A, Greenwood JE. Take of a polymer-based autologous cultured composite skin on an integrated temporising dermal matrix proof of concept J Burn Care Res January-February 2013 34(l) 151-60. 

Wagstaff MJD, Schmitt BJ, Coghlan P, Finkemeyer JP, Caplash Y, Greenwood JE. A biodegradable polyurethane dermal matrix in reconstruction of free flap donor sites a pilot study. ePlasty 2015 15 102-18. 

AlloDerm, acellular dermal matrix bFGF, basic fibroblast growth factor EGF, epidermal growth factor Gelfoam, gelatin from denatured porcine skin HA, hyaluronic acid Surgisis, porcine small intestine submucosa TM, tympanic membrane UBM, urinary bladder matrix. 

Altman AM, Matthias N, Yan Y, Song YH, Bai X, Chiu ES, Slakey DP, Alt EU (2008) Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells. Biomaterials 29(10) 1431-1442... 

The amino acids glycine, proline, lysine and vahne are components of the main proteins of the extracellular dermal matrix. The inclusion of these amino acids in the composition of Hyalrepair, along with other low-molecular bio-regulators and microelements, is essential for triggering synthesis of dermal collagen and elastin, which are extremely important for achieving steady, long-term effect. 

TransCyte (Smith and Nephew) Nylon mesh with dermal matrix secreted by None Burn wounds [56-58]... 

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