Small-diameter vascular grafts

Goissis, G., Suzigan, S., Parreira, D. R., Maniglia, J. V., Braile, D. M., and Raymundo, S. (2000). Preparation and characterization of collagen-elastin matrices from blood vessels intended as small diameter vascular grafts. Artif. Organs 24, 217-223. 

In this study, we describe the modification of PTFE by a chemical method in combination with a biochemical method leading to an improved cell adhesion. The modification was first developed with punched disks from PTEE film, and was then transferred to commercially available vascular grafts made of PTEE. The aim was to retain the mechanical properties of the polymer so that only the biological properties of the inner surface of the graft were changed. Thus it would become possible to couple adhesion proteins to the previously inert and hydrophobic polymer surface to favor adhesion and attachment of endothelial cells (ECs) withstanding shear stress as it occurs in small-diameter vascular grafts. 

Prechtel, E., Yoimg, K., Goldman, S. et al.. Design, synthesis, and mechanical characterization of a resorbable composite small diameter vascular graft as a tissue engineered construct, Trans. Soc. Biomater., 28, 200, 2002. 

G. Soldani, P. Losi, M. Bernabei, S. Burchielli, D. Chiappino, S. Kull, E. Briganti, D. Spiller, Long term performance of small-diameter vascular grafts made of a poly(ether)urethane-polydimethylsiloxane semi-interpenetrating polymeric network. Biomaterials 31 (9) (2010) 2592-2605. 

Fig. 10.7 Examples of biomedical applications of BC are meniscus replacements (pig meniscus on the left, BC meniscus on the right), artificial blood vessels and wound dressing for skin heaiing [76-78], Nanocellulose (bacterial cellulose, BC), such as that produced by Acetobacter xylinum, has shown promising results as a replacement material for small diameter vascular grafts (Fig. 10.8). These BC tubes have been tested in a pig model as an infrarcnal aortic bypass and show promising results for use as vascular grafts in the future...

M D Phaneuf, P JBrown, M J Bide, F W LoGerfo, Nanotechnology in cardiovascular devices Development of a novel small-diameter vascular graft . Proceedings, Biointerface 2004. 

Polytetrafluoroethylene (PTFE, Teflon, Fluorel) is best known for its excellent chemical stability and low coefficient of friction. Expanded PTFE (ePTFE) contains micropores created by stretching PTFE film and is used in small-diameter vascular grafts and for artificial heart valve sewing rings... 

Contreras, M. A., Quist, W. C., and LoGerfo, F. W., Effect of porosity on small-diameter vascular graft healing, Microsurgery, 2000 20(1) 15-21. 

Cardiovascular TE small diameter vascular graft PEUU" Methacrylic acid copolymer attached to ammonia gas plasma-treated surface 50... 

Mize lie S W, Property structure correlations in small diameter vascular grafts , M.S. Thesis, North Carolina State University, Raleigh, NC, USA, 1997. Anderson K and Seyam A M, Developing seamless shaped woven medical products , Journal of Medical Engineering and Technology, 28(3) 110-116, May/June 2004. 

Engineering small-diameter vascular grafts by weaving... 

Using elastomeric threads to construct small-diameter vascular grafts... 

Mize lie SW, Property Structure Correlation in Small Diameter Vascular Grafts , MS thesis. North Carolina State University, Raleigh, NC 27695, USA, 1997. Moghe AK, Study and Characterization of Small Diameter Woven Tubular Fabrics , MS thesis. North Carolina State University, Raleigh, NC 27695, USA, 2002. 

Seventh Concept The use of a surface treatment to improve blood compatibility of the flow surface and reduce the likelihood of emboli being released is an attractive possibility. However, heparinization of polyester to develop a small-diameter vascular graft suitable for coronary artery bypass precludes hemostasis and thus cannot be used clinically. The application of a plasma TFE surface modification to reduce the thrombotic... 

Nakazawa Y, Sato M, Takahashi R, Aytemiz D, Takabayashi C, Tamura T, Enomoto S, Sata M, Asakura T. Development of small diameter vascular grafts based on silk fibroin fibers from Bombyx mori for vascular regeneration. J. Biomat. Set Polym. Ed. 22 195-206,2011. 

Hoffman AS, Ratner BD, Garfinkle A, Horbett TA, Reynolds LO, Hanson SR. Small diameter vascular graft - a challenging biomaterials problem. Proceedings of Materials Research Society, 55(3), doi 10.1557/PROC-55-3, 1985. 

Lovett, M., Eng, G., Kluge, J.A., Cannizzaro, C., Vunjak-Novakovic, G., Kaplan, D.L., 2010. Tubular silk scaffolds for small diameter vascular grafts. Organogenesis 6 (4), 217—224. 

Design of small diameter vascular grafts requires more than a mechanical replica of the vessel. Firstly, it requires the design of an elastomeric polymer with an elastic modulus closely related to that of the natural vessel. The polymer must be tissue compatible and blood compatible. 

Wang X, Lin P, Yao Q, Chen C. Development of small-diameter vascular grafts. World J Surg March 2007 31 682-9. 

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