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Risk assessment framework for

Data derived from comprehensive toxicity testing may be integrated in risk assessment frameworks for a more reliable estimation of the probability that the contaminated site poses environmental harm. Moreover, toxicity tests may be used as screening tools in order to identify polluted soil or water samples, and to reduce the number of samples that require full chemical and/or toxicological analysis. [Pg.229]

JB Rose, CN Haas. A risk assessment framework for the evaluation of skin infections and the potential impact of antibacterial soap washing. Am J Infect Control 27 S26-S33, 1999. [Pg.340]

Nocito JA, Walker HA, Paul JF,Menzie CA (1989) Application of a risk assessment framework for marine disposal of sewage sludge at Midshelf and offshelf sites. In Aquatic toxicology and environmental fate vol 11. ASTM STP 1007. American Society for Testing and Materials, Philadelphia, PA... [Pg.292]

Hartless R. (2004) Developing a risk assessment framework for landfill gas calculating the probability of a landfill gas explosion. Waste 2004, Integrated waste management and pollution control policy and practice, research and solutions. 28-30 September 2004, Stratford-upon-Avon. UK. [Pg.197]

The risk assessment framework we have described for chemical toxicity is applicable to microbial risk assessment. Once the information is available on microbial hazards, which are for the most part acute (immediately observable) conditions resulting from acute (one-time) exposures, and their dose (pathogen count)-response characteristics, we should be ready to assess the risks associated with any dose of interest. Hazard information for the important pathogens is readily available but, as expected, their dose-response characteristics are much harder to come by. So with pathogen risk assessment we see the same types of uncertainties creeping into the framework as we have encountered for chemicals. [Pg.271]

While these contending forces will no doubt continue to contend, and to confuse the public, we should hope that mainstream science and thoughtful risk management policies will prevail. The risk assessment framework is central in the continuing search for the right balance point in these debates. [Pg.313]

The risk assessment framework, first proposed in 1983 by the National Academies committee that prodnced the Red Book, has proved to be durable. Its influence has extended to other areas of risk assessment, and public health authorities who are responsible for understanding and mitigating the truly large public health problems of our time, those associated in part with certain personal behaviors, are beginning to describe their activities within that same framework. [Pg.314]

Looking forward with hope to the continued development and use of the risk assessment framework, and of those scientific disciplines that supply the data and knowledge necessary for its use, I propose the following, perhaps overly grand, definition of risk assessment, in an attempt to ensure its applicability not only to the types of problems that have been the principal subjects of this book, but to all those of public health concern. [Pg.319]

Finally, the diversity of extrapolation techniques relates to the diversity of technical solutions that have been defined in the face of the various extrapolation problems. Methods may range from simple to complex, or from empirical-statistical methods that describe sets of observations (but do not aim to explain them) to mechanism-based approaches (in which a hypothesized mechanism was guiding in the derivation of the extrapolation method). In addition, they may range from those routinely accepted in formal risk assessment frameworks to unique problem-specific approaches, and from laboratory-based extrapolations consisting of 1 or various kinds of modeling to physical experiments that are set up to mimic the situation of concern (with the aim to reduce the need for extrapolation modeling). [Pg.283]

Technical Guidance Document and Water Framework Directive approaches EU member state, North American, and other international approaches) and the way in which they are implemented (e.g., mandatory pass or fail probabilistic, e.g., 95th percentiles or tiered risk assessment frameworks). Soil and water standards were considered, as were values for the protection of human health and the natural environment. The focus was on European regulatory frameworks, although expert input was sought from other jurisdictions internationally. Chemical standards for aquatic (water and sediment) and terrestrial (soil and groundwater) systems were the main focus for the meeting. This workshop built on, and included some participants from, a 1998 SETAC workshop Re-evaluation of the State of the Science for Water-Quality Criteria Development (Reiley et al. 2003). [Pg.2]

Presidential/Congressional Commission on Risk Assessment and Risk Management. Framework for Environmental Health Risk Management, Final Report. The White House, Washington, DC, 1997. [Pg.86]

Marin, C.M. Guvanasen, V. Saleem, Z.A. The 3MRA risk assessment framework—a flexible approach for performing multimedia, multipathway and multireceptor risk assessment under uncertainty. Human Ecol. Risk Assess. 2003, 9, 1-22. [Pg.898]

Application of the HRF increases the transparency of delineation of the relative degrees of nncertainty associated with various options for considraation in assessment of risk for impacted populations. HRFs are also instrumental in acquiring transparency on critical data gaps that will further reduce uncertainty. They force distinction of choices made on the basis of science policy versns those that are science jndgment related, inclnding reliance on default, based on the erroneous premise that it is always health-protective (Meek and Doull 2009). They focus on early events in a toxicity pathway through relation of early perturbations to apical endpoints in frameworks designed to systematically address (a) consideration of key events in modes of action and (b) their snbseqnent implications for dose-response in risk assessment [see, for example. Meek (2008)]. [Pg.393]

Thus, while advances have been made in BBDR modeUng to characteize the shape of the dose-response curve in the low-dose region, some scientists and regulators believe that further model characterization is necessary before integrating these models into the current risk assessment framework. Interestingly, while EPA s National Center for Enviromnental Assessment (NCEA) has not used the formaldehyde BBDR model for toxicity criteria derivation for IRIS, the Toxic Air Programs of EPA have used the model in toxicity assessments under the National Scale Air Toxics Assessment (US EPA 2005e). [Pg.674]

Volume 5 integrates the findings of Volumes 1 to 4 into a risk based framework for development of assessment criteria at TPH contaminated sites. [Pg.176]

Risk Assessment and Risk Management Framework for Decision Making, EPA 600/9-85-00, 1984, 3-18. [Pg.370]

A risk analysis framework for food safety has been developed as an approach to assessing the relationship between potential hazards and the actual human health risks. The three components of risk analysis are assessment, management, and communication. [Pg.84]

Evaluation Methodology for Environmental Impact Assessment of Industrial Wastes Used as Highway Materials An Overview with Respect to U.S. EPA s Environmental Risk Assessment Framework... [Pg.271]

The new approach represents an innovative tool for a more realistic modelling and simulation of the performance of the food chain, i.e. hazard evolution and preventive measures, which is of application to Exposure Assessment within a Quantitative Risk Assessment framework. [Pg.1746]

A process model for safety and lean is presented and examples demonstrate situations where this has not occured. A risk assessment framework is outlined that demonstrates how lean manufacturing concepts and safety can be implemented concurrently. Examples of where safety and lean have been successfully applied are shared. This document also provides design guidelines on how to meet lean objectives without compromising safety. [Pg.266]


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