BBDR Modeling

while advances have been made in BBDR modeUng to characteize the shape of the dose-response curve in the low-dose region, some scientists and regulators believe that further model characterization is necessary before integrating these models into the current risk assessment framework. Interestingly, while EPA s National Center for Enviromnental Assessment (NCEA) has not used the formaldehyde BBDR model for toxicity criteria derivation for IRIS, the Toxic Air Programs of EPA have used the model in toxicity assessments under the National Scale Air Toxics Assessment (US EPA 2005e). 

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Physiologically Based Pharmacokinetic (PBPK) models and Biologically Based Dose-Response (BBDR) models are finding increasing use in risk assessment... 

Use of a biologically based dose-response (BBDR) model that can capture multiple MOAs, which may dominate in different portions of the dose-response curve [e.g., the formaldehyde assessment by The Hamner Institutes for Health Sciences, formerly Chemical Institute of Industrial Toxicology (CUT 2009)], which has been used in regulatory settings (Conolly et al. 2004). 

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