Flexibility approach

An alternative and much more flexible approach is represented hy the STAR file format [L48, 149, which can be used for building self-describing data files. Additionally, special dictionaries can be constructed, which specify more precisely the contents of the eorresponding data files. The two most widely used such dictionaries (and file formats) arc the CIF (Crystallographic Information File) file format [150] - the International Union of Crystallography s standard for representation of small molecules - and mmCIF [151], which is intended as a replacement for the PDB format for the representation of macromolecular structures,... 

PLASTICS MAKE IT POSSIBLE... TO TAKE A FLEXIBLE APPROACH TO RECOVERY WASTE, MAXIMISING ENVIRONMENTAL AND ECONOMIC GAIN APME... 

A much simpler and more flexible approach, however, extends the scheme of pulsed magnetic field gradients discussed above to include more complex time dependences. To see how this can be done, we write down the general dependence of the phase shift accumulated at time t subject to a space-dependent Larmor frequency ... 

Base-induced dimerization of isothiazolium salts containing an active methyl group in the 5-position provides a flexible approach for the synthesis of novel substituted 6aA4-thia-l,6-diazapentalenes. For example, salts 198 and 199 upon treatment with dicyclohexylamine in DMSO yielded the thiadiazapentalenes 200 as shown in Equation (51) and Table 27 <1996MOL142>. 

Based on Table 3.2, we can deduce from the available flow rates that some manufacturers clearly optimized their systems for 2.1 mm inner diameter (ID) columns, namely the Jasco X-LC, the Thermo Accela, and the Waters Acquity. By sacrificing flexibility in column ID, these systems have been completely optimized to these 2.1 mm columns. Achieving that will be explained below. The instruments of Agilent and Dionex mentioned in Table 3.2 involve a more flexible approach. The higher flow rate limits of their systems allow the use of columns with larger Ids. Users benefit from the better efficiency obtained with 4.6 or 3.0 mm ID columns instead of 2.1 mm ID columns of similar length and their systems are fully compatible with existing conventional methods. 

Fiber optic fluorescence thermometry can provide several quite flexible approaches to access the required measurement regions. The temperature probes can be... 

Stachelczyj, D.A. (2000) TransPlusTM a flexible approach for upgrading heavy aromatics. Paper AM-00-60, NPRA, March 26-28, at San Antonio, TX. 

Efforts in precursor control have been particularly successful since the beginning of the twenty-first century, when it became clear that more modern and flexible approaches were necessary, as traffickers have always been quick to switch to new routes, new methods of diversion and new substances. The question is what mechanisms would achieve the maximum results. 

The types of trials to be undertaken demand a flexible approach, and depend on the seriousness of the disease, other therapeutic options and the pharmacokinetics at different ages. For example, if the disease process and efficacy endpoints are similar in adults and children, then an extrapolation from adult efficacy data, together with pharmacokinetic studies in the appropriate paediatric age range, together with safety studies, could form the basis of a successful application. Likewise, it may be possible to extrapolate efficacy from older to younger paediatric groups, with pharmacokinetic and safety studies in the relevant younger study subjects. Where there is no known correspondence between efficacy and... 

A flexible approach to the synthesis of substituted benzazepines 403 was devised (equation 166). As before, the seven-membered ring was made by the use of a ring-expansion reaction and exclusive migration of the aromatic ring was observed. 

A modular and flexible approach to polythiophene sensors based on the polymerization of a thiophene-activated ester has been reported (Bernier et al. 2002). Subsequent reaction of the pol5mierized NHS ester with a variety of diamines permits the synthesis of sensors for different analytes from a common platform. For example, reaction of the NHS polymer with an aminomethyl-modified 15-crown-5 derivative yielded a polymer that underwent color changes in the presence of alkah cations (Fig. 12.14). 

A more flexible approach is due to Bunnett and Olsen (66CJC1899). The general difference between the activity terms for most solutes bases (B), Io8(Vb/Vbh+)> and for Hammett indicators (In), log(v,n/) i H ) is recognized and the simple cancellation of these terms (assumption 2) is replaced by proportionality ... 

The same New Hampshire group have described continuous treatment teams (Drake et al. 1996), who treat the dual diagnosis patients, with 24-hour responsibility for case management. There is a flexible approach to individual and group therapy, the latter being either educational or treatment-oriented in the case of those committed to abstinence. There is a practical focus on social situation, social skills and aspects of daily living. 

It is unfortunate that the term flexible prescribing seems to have rapidly come to be associated with maintenance prescribing , since any one approach to prescribing (whether maintenance or withdrawal) cannot, by definition, be very flexible. However, it is probably inevitable that a move from current clinic policies toward a more flexible approach would increase the number and length of extended prescriptions offered, and this has a number of implications which require consideration and evaluation. 

A more flexible approach to pyrroles has been developed (Tetrahedron Lett. 2004,45,9315) by Keiji Maruoka of Kyoto University. Rearrangement of 5 by the A1 complex 6 leads, by preferential benzyl migration, to the trisubstituted pyrrole 7. 

FDA guidancesa serve as a flexible approach to assist compliance with FDA s requirements. Safety testing of novel and potential excipients is addressed in the... 

One area in which Cl methods appear to be thoroughly superior to perturbation theory is in the treatment of multireference problems problems with substantial nondynamical correlation effects. Even UHF-based single reference perturbation theory methods may not cope with some such situations, and multireference perturbation theory, despite many efforts over the years, still appears to be far from developing a general flexible approach that is competitive with MRCI. Transition-metal chemistry, in particular, is a graveyard for UHF-based MP methods. 

Bennett, M.J., Malone, R.W. and Nantz, M.H. (1995) A flexible approach to synthetic lipid ammonium salts for polynucleotide transfection. Tetrahedron Lett., 36,2207-2210. 

This flexible approach to certification has also led us to take a more holistic view of RM production. Interlaboratory certification studies frequently highlight significant measurement problems, sometimes in a large number of participating laboratories. The tendency has been to make participants aware of this situation through the certification report but to take little other action. In future we aim to provide better value for money to both... 

This flexible approach to guidelines is unique in the sense that the Agency recognizes other reasons beyond scientific development that may be accepted as rationale for a sponsor not to follow rigid guidelines. Some of these include... 

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