Receptor analysis

The purpose of an Exposure Route and Receptor Analysis is to provide methods for estimating individual and population exposure. The results of this step combined with the output of the fate models serve as primary input to the exposure estimation step. Unlike the other analytic steps, the data prepared in this step are not necessarily pollutant-specific. The two discrete components of this analysis are (1) selection of algorithms for estimating individual intake levels of pollutants for each exposure pathway and (2) determination of the regional distribution of study area receptor populations and the temporal factors and behavioral patterns influencing this distribution. 

Wedekind, F., Baer-Pontzen, K., Bala-Mohan, S., Choli, D., Zahn, H., and Brandenburg, D. (1989) Hormone binding site of the insulin receptor Analysis using photoaffinity-mediated avidin complexing. Biol. Chem. Hoppe-Seyler 370, 251-258. 

McFeeters, R. L. and Oswald, R. E. (2002) Structural mobility of the extracellular ligandbinding core of an ionotropic glutamate receptor. Analysis of NMR relaxation dynamics. 

Kuhar MJ, Unnerstall JR. 1990. Receptor autoradiography. Methods in neurotransmitter receptor analysis. Yamamura HI, Enna SJ, Kuhar MJ, editors. New York Raven Press pp. 177-218. 

H. I. Yamamura, S. J. Enna, and M. J. Kuhar, Methods in Neurotransmitter Receptor Analysis, Raven Press, Ltd., New York, 1990. 

Palmer TM, Benovic JL, Stiles GL (1996) Molecular basis for subtype-specific desensitization of inhibitory adenosine receptors. Analysis of a chimeric A Aj adenosine receptor. J Biol Chem 271(25) 15272-15278... 

Lambkin, H. A., Dunne, P., and McCarthy, P. M. 1998. Standardization of estrogen-receptor analysis by immunohistochemistry An assessment of interlaboratory performance in Ireland. Appl. Immunohistochem. 6 103-107. 

Wurch T, Colpaert FC, Pauwels PJ. Chimeric receptor analysis of the ketanserin binding site in the human 5-hydroxytryptaminelD receptor importance of the second extracellular loop and fifth transmembrane domain in antagonist binding. Mol Pharmacol 1998 54 1088-1096. 

Balass M, Katchalski-Katzir E, Fuchs S, The a-bungarotoxin binding site on the nicotinic acetylcholine receptor analysis using a phage-epitope library, Proc. Natl. Acad. Sci. USA, 94 6054-6058, 1997. 

Voltz R, Dalmau J, Posner JB, Rosenfeld MR. T-cell receptor analysis in anti-Hu associated paraneoplastic encephalomyelitis. Neurology 1998 51(4) 1146-1150. 

Applications. From the first successful reports on protein analysis by CE, it became obvious that the unique separation power of the method can be also applied for ligand-receptor analysis to separate bound from free analyte. This is the main prerequisite for evaluating biomolecular interaction by most of the conventional methods. 

Morona, R., Klose, M., and Henning, U. (1984). Escherichia coli K-12 outer membrane protein (OmpA) as a bacteriophage receptor analysis of mutant genes expressing altered proteins. / Baderiol. 159, 570-578. 

Source-receptor analysis was performed to allocate the air chemistry parameters to the individual emission sources. To estimate the impact of a source group on a certain pollutant, several simulations have to be accomplished. To minimize the associated uncertainties (non-linearity of chemical processes), the source group was suppressed. Due to the non-linear chemical processes, background concentrations and advection a non-linear fraction has to be introduced (DG-ENV 2001). The source-receptor analysis is an important tool for abatement and emission reduction strategies. 

CTAP (20), respectively (105,941), which exhibit greatly reduced affinity for somatostatin receptors and enhanced affinity and selectivity for /X receptors. Analysis of CTP by NMR suggested that the central Tyr-o-Trp-Lys-Thr sequence adopts a type IF /3 turn (942). The conformationof these peptides was further restricted and preceptor selectivity further enhanced by incorporation of the constrained amino acid o-Tic in position 1 the resulting peptides TCTP, TCTOP, and TCTAP are potent p antagonists with exceptional selectivity for jLL receptors (Table 7.21) (943,944). Incorporation of either isomer of -Me-n-Phe in position 1 decreases p-receptor affinity and selectivity 10- and 40-fold, respectively (945). 

Balasubramanian S, Xia Y, Freinkman E, Gerstein M (2005) Sequence variation in G-protein-coupled receptors analysis of single nucleotide polymorphisms. Nucleic Acids Res 33 1710-1721... 

Maglich, J.M., Sluder, A.E., Willson, T.M. and Moore, J.T. (2003) Beyond the human genome examples of nuclear receptor analysis in model organisms and potential for drug discovery. American Journal ofPharmacoGenomics, 3, 345-353. 

Tot T. The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract. APMIS. 2000 108 467-472. 

Hormone receptor analysis should be repeated on a resection specimen if the tumor was double negative on core biopsy sample. 

Diaz LK, Sneige N. Estrogen receptor analysis for breast cancer Current issues and keys to increasing testing accuracy. Adv Anat Pathol. 2005 12 10-19. 

TA Aasmundstad, et al. Estrogen receptor analysis—Correlation between enzyme immunoassay and immunohistochemical methods. J Clin Pathol 45 125, 1992. 

Fine Needle Aspiration Impact on Receptor Analysis. 198... 

Several groups have demonstrated excellent quantitative correlation regarding estrogen receptor analysis between the DCC assay and sucrose density-gradient methods (Al, C2, HI), although Chester et al. (C3) found the DCC assay for estrogen receptor to be more sensitive than the sucrose density-gradient analysis and this difference was more pronounced when molybdate was absent. 

R2. Reiner, A., Spona, J., Reiner, G., Schemper, M., Kolb, R., Kwasny, W., Fugger, R., Jakesz, R., and Holzner, J. H., Estrogen receptor analysis on biopsies and fine-needle aspirates from human breast carcinoma. Am. J. Pathol. 125(3), 443-449 (1986). 

---