Regional distribution

Handbook of Chemical Neuroanatomy, Vol. 18 Glutamate O.P. Ottersen and J. Storm-Mathisen. editors Published by Elsevier Science B.V, 

Kainate receptor subunits NMDA receptor subunits  

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Figure 2. Regional Distribution of Emission of Sulphur and Nitrogen Oxides for North America, 1980, adapted from reference 14.

Matthies M, Berding V, Beyer A (2004) Probabilistic uncertainty analysis of the European union system for the evaluation of substances multimedia regional distribution model. Environ Toxicol Chem 3(10) 2494—2502... 

Saleh M, Kamel A, Ragab A, et al. 1996. Regional distribution of organochlorine insecticide residues in human milk from Egypt. J Environ Sci Health B 31(2) 241-255. 

TABLE 3. Regional distribution of apparent [ HJMDA binding... 

Salazar I., Lombardero M., Sanchez-Quinteiro P., Roel P., et al.,. (1998). Origin and regional distribution of the arterial vessels of the vomeronasal organ in the sheep a methodological investigation with SEM and cutting-grinding techniques. Ann Anat 180, 181-187. 

Phencyclidine (1 -[1-phenylcyclohexyl]pi peridine HC1 PCP) and its active derivatives produce unique behavioral effects in animals and psychotomimetic effects in humans. Drugs of this class have been demonstrated to bind saturably, reversibly, and with high affinity to specific binding sites in brain (Hampton et al. 1982 Quirion et al. 1981 Sircar and Zukin 1983 Vincent et al. 1979 Zukin and Zukin 1979). These sites have been shown to exhibit a characteristic heterogeneous regional distribution pattern (Quirion et al. 1981 Sircar et al., submitted for publication Zukin and Zukin 1979) distinct from that of any other receptor type. 

Contreras et al., in press) indicate that PCP binding sites and sigma opioid sites may be distinct due to differences in drug selectivity and regional distribution. 

Multiple opiate receptors Different regional distribution in the brain and differential binding of opiates and opioid peptides. Mol Pharmacol 16 91-104, 1979. 

Contreras, P.G. Quirion, R. and O Donohue, T.L. Comparison of the binding and regional distribution of sigma opioid and phencyclidine receptors. Soc Neuro Sci Abst. in press. 

The question whether PCP and sigma opioids bind to more than one receptor was studied by comparing the binding and regional distribution of binding sites labeled by 3H-PCP, 3H-TCP, 3H-dexoxadrol, ... 

Another method used to study whether these tritiated ligands bind to different groups of binding sites was to determine the regional distribution of binding sites labeled by 3H-TCP and 3H-dexoxadrol. 3H-TCP was used to label PCP receptors because PCP receptors have... 

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