Lobular carcinoma

Most breast carcinomas are adenocarcinomas and are classified as ductal or lobular. 

This prevention was evident in all risk category groups included in Gail s score and with any previous history of breast lesions (atypical hyperplasia, lobular carcinoma in situ, etc.) (Fig. 10.7). 

K18 and K19 (Altmannsberger et al. 1986 Malzahn et al. 1998) including ductal and lobular in situ neoplasia (Bocker et al. 2006 and citations therein). This approach permits to differentiate the following invasive luminal-type carcinomas of the breast ... 

Tumor heterogeneity refers to the existence of distinct subpopulations of tumor cells with specific characteristics within a single neoplasm. Breast cancer is a classic example of a heterogeneous disease. First, the term breast cancer does not itself refer to a single disease. Breast cancers include many different diseases including (but not limited to) adenomas, papillomas, invasive ductal carcinoma, ductal carcinoma in situ (DCIS), and lobular carcinoma in situ (LCIS) (6). 

Zhao H, Langerod A, Ji Y et al. Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell 2004 15 2523-2536. 

Iowa Women s Health Study HRT associated most strongly with an increased risk of invasive breast cancer and modest increases in risk of invasive ductal or lobular carcinoma of the breast (169)... 

In the Iowa Women s Health Study of postmenopausal women for 11 years, during which 1520 specific breast cancers occurred in the at-risk cohort of 37 105 women, it was concluded that exposure to hormone replacement therapy was associated most strongly with an increased risk of invasive breast cancer with a favorable prognosis. There was a more modest increase in the risk of invasive ductal or lobular carcinoma of the breast (169). 

The complexity of the relation between hormonal replacement therapy and breast cancer has been stressed in previous volumes (SED-14, 1454) (SEDA-22, 465), and much depends on the type of replacement therapy given and the class of tumor studied. This latter point has been underscored by a US study that provided evidence that the use of combined hormonal replacement therapy increases the risk of lobular, but not ductal, breast carcinoma in middle-aged women (28). 

Li Cl, Weiss NS, Stanford JL, Daling JR. Hormone replacement therapy in relation to risk of lobular and ductal breast carcinoma in middle-aged women. Cancer 2000 88(ll) 2570-7. 

Houghton JP, Ioffe OB, Silverberg SG, McGrady B, McCluggage WG. Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps report of two cases and review of tamoxifen-associated polypoid uterine lesions. Mod Pathol 2003 16 395-8. 

Lee, A. H. S., Dublin, E. A., Bobrow, L. G., and Poulsom, R. 1998. Invasive lobular and invasive ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis. / Pathol. 785 394-401. 

Radhi, J. M. 2000. Immunohistochemical analysis of pleomorphic lobular carcinoma Higher expression of p53 and chromogranin and lower expression of ER and PgR. Histopathology 36 156-160. 

Coradini D, Pellizzaro C, Veneroni S, Ventura L, Daidone M. Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence. Br J Cancer 2002 87 1105-1 111. 

Salivary gland carcinoma Breast ductal-lobular carcinoma... 

Primary adenocarcinomas of the lung are typically CK7-F, CK20-, and CEA-f, whereas colorectal carcinomas are CK7-, CK20-F, and CEA-i- ductal and lobular breast carcinomas are CK7-f, CK20-, and often CEA-I- and ovarian carcinomas are CK7-I-, CK20 , and CEA-.121,125-129,224-227 Neoplasms that typically are strongly positive for most CEA antibodies include adenocarcinomas of the lung, colon, stomach, biliary tree, pancreas, urinary bladder, endocervix, paranasal... 

Eusebi V, Magalhaes F, Azzopardi JG. Pleomorphic lobular carcinoma of the breast an aggressive tumor showing apocrine differentiation. Hum Pathol. 1992 23 655-662. 

Tot T. The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract. APMIS. 2000 108 467-472. 

Ereedman PD, Lumerman H. Lobular carcinoma of intraoral minor salivary gland origin. Report of twelve cases. Oral Surg Oral Med Oral Pathol. 1983 56(2) 157-166. 

Raju U, Ma CK, Shaw A. Signet ring variant of lobular carcinoma of the breast a clinicopathologic and immunohistochemical study. Mod Pathol. 1993 6 516-520. 

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