Prostate tumors

T. W., Inhibition of rat prostate tumors by controlled release of [D-Trp ]-LHRH from injectable microcapsules, Proc. Int. Symp. Control. Rel. Bioact. Mater., 11, 88, 1984. 

SAKAMOTO K (2000) Synergistic effects of thearubigin and genistein on human prostate tumor cell (PC-3) growth via cell cycle arrest . Cancer Lett, 151 (1), 103-9. 

Prostatic tumor volume contributes to the levels of serum PSA as well as pathological staging, with higher PSA concentrations associated with advanced staging. In the majority of men, PSA concentrations at the time of surgery were found to be <4 ng/ml (organ confined). Half of those with PSA concentrations > 10 ng/ml had capsular penetration, whereas those with PSA values >50 ng/ml showed positive pelvic lymph nodes. 

Festuccia, C, V Dolo, F Guerra et al. 1998. Plasminogen activator system modulated invasive capacity and proliferation in prostatic tumor cells. Clin Exp Metastasis 16 513-528. 

Elek J et al. Microarray-based expression profiling in prostate tumors. In vivo 2000 14 173-182. 

Peng WD, Anderson DG, Bao YH, Padera RF, Langer R, Sawicki JA (2007) Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors. Prostate 67 855-862. 

Cattaneo-Pangrazzi RMC, et al. New amphiphilic heterodinucleoside phosphate dimers of 5-fluorodeoxyuridine (5FdUrd) cell cycle dependent cytotoxicity and induction of apoptosis in PC-3 prostate tumor cells. Biochem Pharmacol 2000 60 1887. 

Wellmann et al. (2002) also examined prostate carcinoma with the aid of laser-assisted microdissection and SELDI to analyze protein extracts from about 500 cells. A number of differentially expressed proteins in the 1.5- to 30-kDa range were found between normal prostate gland cells and prostate tumors. A prominent (threefold) up-regulated protein peak at mass 4299 Da was observed for prostate tumor cells. The average relative intensities were 24.37 for tumor cells, 9.99 for transitional zone cells, and 7.26 for normal prostate cells. 

LHRH receptors Breast tumor, prostate tumors... 

Takagi A, Watanabe M, Ishii Y et al (2007) Three-dimensional cellular spheroid formation provides human prostate tumor cells with tissue-like features. Anticancer Res 27 45-53... 

Rat breast tumor, prostate tumor, human lymphoma xenograft [10,214, 215,217,267,270]... 

Rat heart, rat prostate tumor, rabbit liver, pig lungs, phantom [241,250,432,433]... 

L. Liu, V.D. Kodibagkar, J.-X. Yu, R.P. Mason, F-NMR detection of lacZ gene expression via the enzymic hydrolysis of 2-fluoro-4-nitrophenyl -o-galactopyranoside in vivo in PC3 prostate tumor xenografts in the mouse, Faseb J. 21(2007) 2014-2019. 

Hopp, D.C., Zeng, L., Gu, Z.-M., and McLaughlin, J.L. Squamotacin an Annonaceous acetogenin with cytotoxic selectivity for the human prostate tumor cell line (PC-3). J. Nat. Prod., 59,97,1996. 

In four patients with prostate tumors who were treated with exemestane (two with and two without bicalutamide) there was progression of the tumor after 4 weeks, assessed by measurement of prostate-specific antigen and radiological signs (35). Three of the four had a significant increase in bone pain only a few days after starting treatment and a clear improvement in these symptoms after... 

Leung, S. Y. L., J. Jackson, H. Miyake, H. Burt, and M. E. Gleave. 2000. Polymeric micellar paclitaxel phos-phorylates Bcl-2 and induces apoptotic regression of androgen-independent LNCaP prostate tumors. Prostate44 156-163. 

Becker C, Lilja H. Individual prostate-specific antigen (PSA) forms as prostate tumor markers. Clin Chim Acta 1997 257 117-132. 

J. A. Marton, L. J. Valasinas, A. Basu, H. S. Cyclopropane-containing polyamine analogues are effident growth inhibitors of a human prostate tumor xenograft in nude mice. /. Med. Chem. 2003, 46, 4586—4600. 

D. C. Yu, Y. Chen, M. Seng, J. Dilley, and D. R. Henderson, The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts, Cancer Res. 59 4200 (1999). 

Hormonal therapy Hormone refractory prostate tumors Somatic missense mutations (e.g. Thr877Ala in exon 1) create tumors refractory to hormonal therapy (60-63)... 

Flutamide Paradoxical response to flutamide Hypothesize that polymorphism in glutamine (CAG) repeat length creates a receptor that affects prostate tumor response to anticancer agents (33,66)... 

Rebbeck TR, Jaffe JM, Walker AH, et al. Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4. J Natl Cancer Inst 1998 90 1225-1229. 

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