Bone pain

Strontium-89 chloride is a calcium analogue that rapidly clears from the blood and is taken up into bone mineral, particularly in areas of active osteogenesis, as weU as primary bone tumors and metastases. It is used for reHef of bone pain in patients having painful skeleton bone metastases. It is suppHed in an injectable solution. 

Clinically, GM-CSF or G-CSF have been used to accelerate recovery after chemotherapy and total body or extended field irradiation, situations that cause neutropenia and decreased platelets, and possibly lead to fatal septic infection or diffuse hemorrhage, respectively. G-CSF and GM-CSF reproducibly decrease the period of granulocytopenia, the number of infectious episodes, and the length of hospitalization in such patients (152), although it is not clear that dose escalation of the cytotoxic agent and increased cure rate can be rehably achieved. One aspect of the effects of G-CSF and GM-CSF is that these agents can activate mature cells to function more efficiently. This may, however, also lead to the production of cytokines, such as TNF- a, that have some toxic side effects. In general, both cytokines are reasonably well tolerated. The side effect profile of G-CSF is more favorable than that of GM-CSF. Medullary bone pain is the only common toxicity. 

Lentaron) gosetelin USP [65807-02-5] C59Hg4NigOi4 1269.43 (63) postmenopausal breast cancer prostatic carcinoma bone pain common... 

Osteoarthritis is a disease of the load-bearing joints, characterised by gradual erosion of cartilage and deformation of bone. Pain is the main symptom, initially eased by rest, but later analgesics such as aspirin-like drugs are indicated. 

Headache, abdominal pain, arthralgia, recurrent bone pain, nausea, diarrhea, esophageal ulceration, dysphagia... 

Adverse reactions with the bisphosphonates include nausea, diarrhea, increased or recurrent bone pain, headache, dyspepsia, acid regurgitation, dysphagia, and abdominal pain. 

ISPHOSPHONATES The nurse monitors the patient taking the bisphosphonates for any adverse reactions such as nausea, diarrhea, increased or recurrent bone pain, headache dyspepsia, acid regurgitation, dysphagia, and abdominal pain. Analgesic maybe administered for headache Notify the primary health care provider of adverse reactions such as the return of bone pain or severe diarrhea... 

Aluminum-containing antacids—constipation, intestinal impaction, anorexia, weakness, tremors, and bone pain... 

Hot flushes, hypertension, dizziness, paresthesia, insomnia, rash, constipation, nausea, diarrhea, nocturia, hematuria, peripheral edema, bone pain, dyspnea, general pain, back pain, asthenia, infection... 

Edema, headache, dizziness, bone pain, nausea, vomiting, anorexia, ECG changes, hypertension... 

Primary hyperparathyroidism occurs as a result of hyperplasia or the occurrence of adenoma. Secondary hyperparathyroidism may result from renal failure because of the associated phosphate retention, resistance to the metabolic actions of PTH, or impaired vitamin D metabolism. The last-mentioned factor is primarily responsible for the development of osteomalacia. Muscle symptoms are much more common in patients with osteomalacia than in primary hyperparathyroidism. Muscle biopsy has revealed disseminated atrophy, sometimes confined to type 2 fibers, but in other cases involving both fiber types. Clinical features of osteomalacic myopathy are proximal limb weakness and associated bone pain the condition responds well to treatment with vitamin D. 

Tremor Increased blood pressure Mood lability Depression Muscle spasms Weakness Bone pain... 

Cardiovascular Increased stroke index, heart rate, and diastolic and mean arterial pressures Musculoskeletal Bone pain, muscle weakness Dermatologic Pruritus... 

Letrozole is another selective aromatase that inhibits the conversion of androgens to estrogen. Maximum plasma concentrations occur 1 hour after oral dosing concomitant food has not been shown to have an effect on the extent of absorption of letrazole. The terminal half-life is approximately 2 days. Letrozole is used in the treatment of postmenopausal women with hormone-receptor-positive or unknown advanced breast cancer. Side effects include bone pain, hot flushes, back pain, nausea, arthralgia, osteoporosis/bone fractures, and dyspnea. 

For women whose breast cancer has metastasized to bone, bisphosphonates are recommended, in addition to chemotherapy or endocrine therapy, to reduce bone pain and fractures.28,64 Pamidronate (90 mg) and zoledronate (4 mg) can be given intravenously once each month. These bisphosphonates are given in combination with calcium and vitamin D. 

The most common adverse effects reported with LHRH agonist therapy include a disease flare-up during the first week of therapy, hot flashes, erectile impotence, decreased libido, and injection-site reactions.19 The disease flare-up is thought to be caused by initial induction of LH and FSH by the LHRH agonist and manifests clinically as either increased bone pain or increased urinary symptoms.19 This flare reaction usually resolves after 2 weeks and has a similar onset and duration pattern for the depot LHRH products.33,34... 

CC is a 69-year-old man who presents with metastatic prostate cancer. His disease is metastatic to the bones, and his primary symptom is bone pain. 

Lymphadenopathy, massive hepatosplenomegaly, and bone pain are not as common in AML as in ALL. 

Patients often present with bone pain secondary to expansion of the marrow cavity from leukemic infiltration. 

Bisphosphonates should be initiated in patients with lytic bone lesions. Renal function must be monitored. Patients may need pain medication for bone pain. 

Although generally well tolerated, CSFs may cause bone pain in around 25% of patients. This may be managed with acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs), although attention to the platelet count is warranted with the use of NSAIDs. Sargramostim in particular may result... 

Filgrastim Neupogen GCSF Neutrophil 5 mcg/kg per day SQ or IV or round to 300- or 480-mcg vial size Bone pain (approximately 25%) Begin 1-3 days after chemotherapy... 

Macrophage 250- or 500-mcg vial size Bone pain Injection-site skin reaction older patients with AML Limited experience and lack of FDA approval for prevention of febrile neutropenia... 

Musculoskeletal weakness, bone pain, fatigue, and ataxia... 

Sambucus javanica, known as Ch ou ts ao, meaning "stinkweed," is warm and sweet. As a medicine it is employed to reduce swelling. Topically, both varieties are used for bone pain, swellings, muscular spasms and traumatic injuries. 

Lu-EDTMP was evaluated as a bone pain palliation agent and found in animal studies (rabbits) to be comparable to 153Sm-EDTMP.187... 

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