Prostate tumors oncogenes

Sun, Y, Lin, J., Katz, A.K. et al. (1997) Human prostatic carcinoma oncogene PTI-1 is expressed in human tumor cell lines and prostate carcinoma patient blood samples. Cancer Res, 57, 18-23. 

Fixemer, T., Wissenbach, U., Flockerzi, V. and Bonkhoff, H., 2003, Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer a novel prognostic marker for tumor progression. Oncogene 22, 7858-61. 

COX-2 overexpression also has been detected in prostate adenocarcinoma (Gupta et al, 2000 Yoshimura et al, 2000). The expression of COX-2 in tumors, was found to be upregulated by various oncogenes such as Her-2 or ras and downregulated by tumor suppressor genes like p53 (Subbaramaiah et al., 1999 Subbaramaiah et al, 2002). Several COX-2 inhibitors such as celecoxib and NS-398, have been demonstrated to induce apoptosis in prostate cancer cell lines (Hsu et al., 2000 Liu et al., 1998). 

Patrawala L, Calhoun T, Schneider-Broussard R et al. (2006) Highly purified CD44 + prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 25 1696-1708... 

The human cancer antigene R (HuR) translocates in tumor cells from the nucleus into the cytoplasm to stabilize cyclins in uninterrupted cell divisions to force the overexpression of ERBB-2 in prostate cancer cells (c-erb v-erb avian erythroblastic leukemia retrovims oncogene EGF-R) [670]. K usually used for lysine. 

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