Procedure hazard form

A procedure hazard form should contain all the necessary information regarding potential hazards, mode of disposal and first aid for all the chemicals... 

Every activity in the laboratory should be assessed for the potential hazards involved and all the relevant information should be presented in a standard format known variously as procedure hazard forms or material safety data... 

Many of the incidents in this book were the result of leaks of hazardous materials, and the recommendations describe ways of preventing leaks by providing better equipment or procedures. As we have seen, equipment can fail or can be neglected, and procedures can lapse. The most effective methods, therefore, of preventing leaks of hazardous materials are to use so little that it hardly matters if it all leaks out (intensification or minimization) or to use a safer material instead (substitution). If we cannot do this and have to store or handle large amounts of hazardous material, we should store or handle it in the least hazardous form (attenuation or moderation). Plants in which this is done are said to be inherently safer because they are not dependent on added-on equipment or procedures that might fail the hazard is avoided rather than controlled, and the safety is inherent in the design. 

In an early report on peptide hydroxamic acids as metalloprotease inhibitors, the peptide acid (Z-Gly-L-Leu-OH) was converted into the V-hydroxysuccinimide ester using DCC, which was subsequently reacted with hydroxylamineJ10 More reactive condensing reagents such as BOP can form the hydroxamic acid directly from the carboxylic acid and hydroxylamine via an intermediate HOBt ester. A number of hydroxamic acids has been synthesized by the treatment of the corresponding methyl esters with hydroxylamine in the presence of KOH 122 this reaction requires careful choice of reagent concentrations and ratios. In addition, the precursor carboxylic acid is treated with diazomethane to make the methyl ester. The use of diazomethane makes the procedure hazardous, but should be useful in special cases that require a better cost performance. 

It is best to have a formal procedure for recording employee-identified hazards. This can be easily accomplished by a hazard form that provides a written record of the hazard, its location, and other pertinent information, such as the number of employees exposed and possible hazard-control measures. These forms can be distributed to each employee and be available from the department committee member. Employees may wish to express their views about the existence of potential hazards anonymously on the forms. Employees should report near-miss accidents, property damage incidents, and potential injury-producing hazards. It is essential in a program such as this that employees be given anonymity if desired and that they be assured that no action will be taken against them for their participation (even if they report silly hazards). 

Features for fire prevention were the mechanical properties of some metal material containers and radioactive material form to prevent or reduce the release, and sprinkler fire suppression systems to prevent or delay ignition of combustible materials. In addition, administrative operating procedures, hazardous materiai handling training and packaging requirements could also help prevent or mitigate a fire caused by an electrical wiring short or overheat. 

Dow Fire and Explosion Index. The Dow Eire and Explosion Index (3) is a procedure usehil for determining the relative degree of hazard related to flammable and explosive materials. This Index form works essentially the same way as an income tax form. Penalties are provided for inventory, extended temperatures and pressures, reactivity, etc, and credits are appHed for fire protection systems, process control (qv), and material isolation. The complete procedure is capable of estimating a doUar amount for the maximum probable property damage and the business intermptionloss based on an empirical correlation provided with the Index. 

This can be a dangerous procedure due to the potential growth of food poisoning bacteria such as Staphylococcus aureus (31). This method of inoculation requites a very strict condition to assure the absence of not only bacteria associated with a health hazard but also those associated with product failure (proteolytic, greening, and gas-forming microorganisms). 

As microprocessor-based controls displaced hardwired electronic and pneumatic controls, the impac t on plant safety has definitely been positive. When automated procedures replace manual procedures for routine operations, the probability of human errors leading to hazardous situations is lowered. The enhanced capability for presenting information to the process operators in a timely manner and in the most meaningful form increases the operator s awareness of the current conditions in the process. Process operators are expected to exercise due diligence in the supervision of the process, and timely recognition of an abnormal situation reduces the likelihood that the situation will progress to the hazardous state. Figure 8-88 depicts the layers of safety protection in a typical chemical jdant. 

For PM applications, wet scrubbers generate waste in the form of a slurry or wet sludge. This creates the need for both wastewater treatment and solid waste disposal. Initially, the slurry is treated to separate the solid waste from the water. The treated water can then be reused or discharged. Once the water is removed, the remaining waste will be in the form of a solid or sludge. If the solid waste is inert and nontoxic, it can generally be landfilled. Hazardous wastes will have more stringent procedures for disposal. In some cases, the solid waste may have value and can be sold or recycled. 

The effectiveness of incineration has most commonly been estimated from the heating value of the fuel, a parameter that has little to do with the rate or mechanism of destraction. Alternative ways to assess the effectiveness of incineration destraction of various constituents of a hazardous waste stream have been proposed, such as assessment methods based on the kinetics of thermal decomposition of the constituents or on the susceptibility of individual constituents to free-radical attack. Laboratory studies of waste incineration have demonstrated that no single ranking procedure is appropriate for all incinerator conditions. For example, acceptably low levels of some test compounds, such as methylene chloride, have proved difficult to achieve because these compounds are formed in the flame from other chemical species. 

The chlorination of methyl chloroformate in sunlight was first reported by Hentschel, but without a detailed description of either the procedure or the results. The first step of the present procedure for the preparation of trichloromethyl chloroformate utilizes an ultraviolet light source and affords a simple and reproducible way to obtain this reagent. Although trichloromethyl chloroformate may also be synthesized by photochemical chlorination of methyl formate,the volatility of methyl formate causes losses during the reaction and increases the hazard of forming an explosive mixture of its vapor and chlorine gas. The preparation of trichloromethyl chloroformate by chlorination of methyl chloroformate in the dark with diacetyl peroxide as initiator has been reported. However, the procedure consists of several steps, and the overall yield is rather low. 

The ventilation system must be able to carry away hazardous fumes that may form during normal work. Monitoring the laboratory atmosphere for such fumes while work is in progress is not only advisable, but may even be required by law. Monitoring must be repeated whenever new fume-producing procedures are introduced or any time modifications are made to the ventilation system. Local health authorities should be contacted about... 

Viruses are infectious particles formed by nucleic acid, proteins, and in some cases lipids. As viruses (for example, retro- and adenoviruses) transfer viral genes into cells with high efficiency, modified forms are sometimes used as vectors for gene transfer. However, procedures using virus-based vectors are often significantly more complicated and time-consuming than other transfection methods. In addition, viral vectors are potentially hazardous, and biological safety issues need to be considered carefully. Therefore, techniques that combine... 

An application of transport and compartment-type models to hazard analysis is described in the paper by Honeycutt and Ballantine (19). The compound CGA-72662 running off from agricultural areas into surface waters was modeled in order to set safe application procedures consistent with the protection of aquatic environments. Patterson, et al (2 0) have adapted the UTM model to a software package that is generally applicable to fate assessments of toxic substances in air, water, soil and biota. Their work, now in working draft form, is being used by Dr. William Wood and Dr. Joan Lefler in the Office of Toxic Substances of the U.S. Environmental Protection Agency. 

Direct preparation of the gas is potentially hazardous, and explosive decomposition of the impure gas in the condensed state (below -20°C) has occurred. A safe procedure involving isolation of the 1 1 adduct with 9,10-dimethylanthracene is preferred. The impure gas contains nitrogen oxide and it is known that nitrosyl cyanide will react with the latter to form an explosive compound [1], The need to handle this compound of high explosion risk in small quantities, avoiding condensed states, is stressed [2],... 

Picric acid, in common with several other polynitrophenols, is an explosive material in its own right and is usually stored as a water-wet paste. Several dust explosions of dry material have been reported [1]. It forms salts with many metals, some of which (lead, mercury, copper or zinc) are rather sensitive to heat, friction or impact. The salts with ammonia and amines, and the molecular complexes with aromatic hydrocarbons, etc. are, in general, not so sensitive [2], Contact of picric acid with concrete floors may form the friction-sensitive calcium salt [3], Contact of molten picric acid with metallic zinc or lead forms the metal picrates which can detonate the acid. Picrates of lead, iron, zinc, nickel, copper, etc. should be considered dangerously sensitive. Dry picric acid has little effect on these metals at ambient temperature. Picric acid of sufficient purity is of the same order of stability as TNT, and is not considered unduly hazardous in regard to sensitivity [4], Details of handling and disposal procedures have been collected and summarised [5],... 

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