Assessment of methods

The choice of method must depend upon the exact nature of the problem to be solved. Methods providing a number-average are clearly 

The ultracentrifuge gives the clearest indication of the polydispersity of a polymer, and in conjunction with diffusion measurements it provides a reliable weight-average. 

Too few measurements of polysaccharides have yet been made by light-scattering to assess its value for these polymers, but it may be inferred from work carried out on other systems that it has considerable potentialities. 

Clearly as many methods as possible should be combined to obtain complete characterization of a polysaccharide. 

---

Moult J, T Hubbard, K Fldelis and J T Pedersen 1999. Critical Assessment of Methods of Protein Structure Prediction (CASP) Round III. Proteins Structure, Function and Genetics Suppl. 3 2-6. 

J Moult, T Flubbard, SFI Bryant, K Fidelis, JT Pedersen. Critical assessment of methods of protein structure prediction (CASP) Round II. Proteins Suppl 1 2-6, 1997. 

Requirements for standards used In macro- and microspectrofluorometry differ, depending on whether they are used for Instrument calibration, standardization, or assessment of method accuracy. Specific examples are given of standards for quantum yield, number of quanta, and decay time, and for calibration of Instrument parameters. Including wavelength, spectral responslvlty (determining correction factors for luminescence spectra), stability, and linearity. Differences In requirements for macro- and micro-standards are considered, and specific materials used for each are compared. Pure compounds and matrix-matched standards are listed for standardization and assessment of method accuracy, and existing Standard Reference Materials are discussed. 

Bacquet, R. J., Erion, M. D. Assessment of methods used for predicting lipophilidty application to nucleosides and nudeoside bases. J. Comput. Chem. 1993, 14, 1019-1026. 

The numerical solution of large matrix eigenvalue problems is one of the most frequently encountered computation tasks of a standard, yet nontrivial nature. Consequently, there is great theoretical and practical interest in the invention, modification and assessment of methods to cope with this problem. This chapter will describe some well-established methods, currently of widespread use in quantum-chemistry programs. 

Viswanadhan, V. N., et al., Assessment of Methods Used for Predicting Lipophilicity Application to Nucleosides and Nucleoside Bases. J. Comput. Chem., 1992 14, 1019— 1026. 

Section 5.1 presents the fundamental method as the heart of the chapter— the statistical thermodynamics approach to hydrate phase equilibria. The basic statistical thermodynamic equations are developed, and relationships to measurable, macroscopic hydrate properties are given. The parameters for the method are determined from both macroscopic (e.g., temperature and pressure) and microscopic (spectroscopic, diffraction) measurements. A Gibbs free energy calculation algorithm is given for multicomponent, multiphase systems for comparison with the methods described in Chapter 4. Finally, Section 5.1 concludes with ab initio modifications to the method, along with an assessment of method accuracy. 

NIVA Consultants, Inc., Science Applications International Corporation, Southwest Research Institute, Stone and Webster Engineering Corporation. 1999. Assessment of Methods to Analyze VX in Caustic Hydrolysate and Resultant Path Forward (July 21, 1999). Aberdeen... 

Pauletti, G., Dandekar, S., Rong, H.-M., Ramos, L., Peng, H., Seshadri, R., and Slamon, D. J. 2000. Assessment of methods for tissue-based detection of the HER-2/wew alteration in human breast cancer A direct comparison of fluorescence in situ hybridization and immunohistochemistry. J. Clin. Oncol. 18 3651-3661. 

Green, R.E., J.M. Davidson, and J.W. Biggar. 1980. An assessment of methods for determining adsorption-desorption of organic chemicals. In A. Banin and U. Kafkefi, Eds., Agrochemicals in Soils. New York Pergamon Press, pp. 73-82. 

K. Hemminki, o. Axelsson, M-L. Niemi, and et al. Assessment of methods and results of reproductive occupational epidemiology spontaneous abortions and malformations in the offspring of working women. Am. J. Ind. Med. 4, 1983, 293. 

An additional phase of method feasibility that is often overlooked is an assessment of method items that may not have an equivalent replacement. In HPLC, an obvious item that falls under this category is the HPLC column. Other items, however, such as the actual instruments, equipment, reagents, and supplies used, must be evaluated during feasibility. It is important that... 

Burmaster, D.E., Menzie, C.A., Freshman, J.S., Burris, J.A., Maxwell, N.I., Drew, S.R. (1991) Assessment of methods for estimating aquatic hazards at superfund-type sites A cautionary tale. Environ. Toxicol. Chem. 10, 827-842. 

B. Commoner, M. McNamara, K. Shapiro and T. Webster, Environmental and Economic Analysis of Alternative Mimicipal Solid Waste Disposal Technologies IE The Origins of Chlorinated Dioxins and Dibenzofurans Emitted by Incinerators that Burn Unseparated Municipal Solid Waste, and an Assessment of Methods of Controlling Them, Center for the Biology of Natural Systems, Queens College, Flushing, New York, 1984. 

CASP Critical assessment of methods of protein structure prediction... 

Camara, C., Comelis, R., Quevauviller, P. Assessment of methods currently used for the determination of Cr and Se species in solutions. Trends Anal. Chem. 19, 189-194 (2000)... 

Moult J, Fidelis K, Kryshtafovych A, Rost B, Hubbard T, Tra-montano A. Critical assessment of methods of protein structure prediction-Round Vll. Proteins. 2007 69 3-9. 

Taylor, ]., Alderson, J., Kalyanam, K., Lyle, A., Phillips, L. (1986). Technical and economic assessment of methods for the storage of large quantities of hydrogen. Int. J. Hydrogen Energy 11,5-22. 

Assessment of method performance using authentic samples under authentic conditions... 

Interlaboratory quality audit program for potable water - assessment of method validation done on inductively coupled plasma atomic emission spectrometer (ICP-AES)... 

---