Plasmodium berghei malaria

Wysor MS. 1975. Orally administered silver sulfadiazine Chemotherapy and toxicology in CF-1 mice Plasmodium berghei (malaria) and Pseudomonas aerygubis. Chemotherapy 21 302-310. 

Apicomplexan parasites cause life threatening diseases like malaria, cryptosporid-iosis, toxoplasmosis, coccidiosis. Suberic acid bisdimethylamide which also inhibits HDA selechvely arrests tumor cells as opposed to normal mammalian cells, has an in vivo cytostatic effect against the acute murine malaria Plasmodium berghei (Andrews et al, 2000). 

Simtharasamai, P., and Marsden, P. D., Studies of splenomegaly in rodent malaria. Ill Protein-calorie malnutrition and splenomegaly in mice infected with Plasmodium berghei yoeii. Trans. Roy. Soc. Trop. Med. Hyg. 66, 214-221 (1972). 

Berberine chloride was evaluated for antimalarial activity against Plasmodium falciparum in vitro (two clones of human malaria Plasmodium falciparum D-6 [Sierra Leone clone] and W-2 (Indochina clone) and Plasmodium berghei in vivo (mice). The alkaloid exhibited an antimalarial potency equivalent to that of quinine in vitro, but was inactive in vivo. The results were consistent with those of others who have found berberine to be a potent inhibitor in vitro of both nucleic acid and protein biosynthesis in P. falciparum, and have demonstrated a strong interaction of berberine with DNA. In addition, the lack of in vivo antimalarial activity in mice observed with berberine and other protoberberine alkaloids agrees with clinical reports that have claimed berberine to be inactive as an antimalarial drug [228]. 

Jatrorrhizine chloride was evaluated for antimalarial activity against Plasmodium falciparum in vitro (two clones of human malaria Plasmodium falciparum D-6 [Sierra Leone clone] and W-2 (Indochina clone) and Plasmodium berghei in vivo (mice). The alkaloid exhibited an antimalarial potency equivalent to that of quinine in vitro, but was inactive in vivo [228],... 

Brinkmann V, Kaufmann SH, Simon MM, et al Role of Macrophages in Malaria 02 Metabolite Production and Phagocytosis by Splenic Macrophages During Lethal Plasmodium berghei and Self-limiting Plasmodium yoelii Infection in Mice. Infect. Immun. 1984 44(3) 7434. 

Owais, M., Varshney, G. C., Choudhury, A., Chandra, S., and Gupta, C. M. (1995) Chloroquine encapsulated in malaria-infected erythrocytes-specific antibodybearing liposomes effectively controls chloroquinc-rcsistan t Plasmodium berghei infections in mice. Antimicrob. Agents Chemother. 39,180-184. 

In 1998, using the rodent malaria parasite Plasmodium berghei, and following advances in mass spectrometry, Oliver Billker and colleagues... 

Some time in 1968, Carter saw his first enzyme variants —beautiful little bands of sky blue on a China white gel (a flat slab of starch gel on a glass plate that had been laid between electrodes), each band at a precise and different position on the gel according to the strain of malaria parasite whose content had been extracted for electrophoretic separation (Carter, 1970). They were the biochemical genetic markers of two strains of Plasmodium berghei yoelii (as then defined), 17X and 33X that Walliker needed in order to be able to analyze a genetic cross between these two parasites. 

Joseph and Judith Ilan (then at Temple University, Philadelphia, Pennsylvania) and now at Case Western Reserve University (Cleveland, Ohio) were attracted to work on malaria parasites because of their biochemical expertise, the availability of funding from the United States Army and the fact that Judith s father was the eminent Israeli parasitologist Saul Adler. They based their contention on the following observations after injecting Plasmodium berghei-infected mice with NaH32P04 the... 

Bowman, I. B., Grant, P. T., Kermack, W. O., and Ogston, D. (1961). The metabolism of Plasmodium berghei, the malaria parasite of rodents. 2. An effect of mepacrine on the metabolism of glucose by the parasite separated from its host cell. Biochem. ]. 78,472-478. 

Bungener, W., and Nielsen, G. (1968). Nucleic acid metabolism in experimental malaria. 2. Incorporation of adenosine and hypoxanthine into the nucleic acids of malaria parasites (Plasmodium berghei and Plasmodium vinckei). Z. Tropenmed. Parasitol. 19,185-197. 

Carter, R. (1978). Studies on enzyme variation in the murine malaria parasites Plasmodium berghei, P. yoelii, P. vinckei and P. chabaudi by starch gel electrophoresis. Parasitology 76, 241-267. 

Krungkrai, J., Cerami, A., and Henderson, G. B. (1991). Purification and characterization of dihydroorotate dehydrogenase from the rodent malaria parasite Plasmodium berghei. Biochemistry 30,1934 1939. 

Neame, K. D., and Homewood, C. A. (1975). Alterations in the permeability of mouse erythrocytes infected with the malaria parasite, Plasmodium berghei. Int. ]. Parasitol. 5,537-540. 

Penet, M. F., Kober, F., Confort-Gouny, S., Le Fur, Y., Dalmasso, C., Coltel, N., Liprandi, A., Gulian, J. M., Grau, G. E., Cozzone, P. J., and Viola, A. (2007). Magnetic resonance spectroscopy reveals an impaired brain metabolic profile in mice resistant to cerebral malaria infected with Plasmodium berghei ANKA.. Biol. Chem. 282,14505-14514. 

Promeneur, D., Liu, Y., Maciel, J., Agre, P., King, L. S., and Kumar, N. (2007). Aquaglycer-oporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei. Proc. Natl. Acad. Sci. USA 104, 2211-2216. 

Raibaud, A., Brahimi, K., Roth, C. W., Brey, P. T., and Faust, D. M. (2006). Differential gene expression in the ookinete stage of the malaria parasite Plasmodium berghei. Mol. Biochem. Parasitol. 150,107-113. 

Webster, H. K., Wiesmann, W. P., and Pavia, C. S. (1984b). Adenosine deaminase in malaria infection Effect of 2 -deoxycoformycin in vivo. Adv. Exp. Med. Biol. 165(Pt A), 225-229. Weidekamm, E., Wallach, D. F., Lin, P. S., and Hendricks, J. (1973). Erythrocyte membrane alterations due to infection with Plasmodium berghei. Biochim. Biophys. Acta 323,539-546. Wellems, T. E., Walker-Jonah, A., and Panton, L. J. (1991). Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7. Proc. Natl. Acad. Sci. USA 88,3382-3386. 

Yoeli, M., Vanderberg, J., Nawrot, R., and Most, H. (1965). Studies on sporozoite-induced infections of rodent malaria. II. Anopheles stephensi as an experimental vector of Plasmodium berghei. Am. ]. Trop. Med. Hyg. 14,927-930. 

Potentiated Disease. Vaccination can induce immune responses that establish a condition that potentiates disease upon subsequent exposure to the pathogen. Preclinical studies to evaluate adjuvanted protein-based vaccines comprising helper T cell and/or B cell epitopes from Plasmodium berghei indicated that vaccinated mice died earlier of malaria than unvaccinated control mice, a finding attributed to the immune response induced against the T cell epitope and a nonspecihc effect of the adjuvant (Reed et al., 1997). 

Fairfield, A. S., Eaton, J. W. and Meshnick, S. R. (1986) Superoxide dismutase and catalase in the murine malaria, Plasmodium berghei content and subcellular distribution. Arch. Biochem. Biophys. 250 526-529. 

Mohmmed A, et ai. (2003). In vivo gene silencing in Plasmodium berghei-a mouse malaria model. Biochem. Biophys. Res. Commun. 309(3) 506-511. 

Chen L, Sendo F Cytokine and chemokine mRNA expression in neutrophils from CBA/NSlc mice infected with Plasmodium berghei ANKA that induces experimental cerebral malaria. Parasitol Int 2001 50 139-143. 

It was found that in mice infected with Plasmodium berghei, the malaria parasite caused an increase in hypnotic sensitivity of the mice to a number of barbiturates. This increase in activity appears to be due in part to a decrease in the detoxifying action of the liver and possibly to adrenal injury [157]. 

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