Plasmodium yoelii

SERCA-type -ATPases from non-mammalian cells (SERCAMED) Sequences of SERCA-type Ca -ATPases were also obtained from Plasmodium yoelii [68], Anemia [69] and Drosophila [70], These enzymes are similar in size to the SERCAl- and SERCA2a-type Ca -ATPases from mammalian muscles, but based on their N- and C-terminal sequences they represent a distinct group. In spite of the wide philogenetic variations between them they all share a common N-term-inal sequence (MED) that differs from mammalian enzymes. None of the corresponding proteins were isolated and characterized. 

SERCAMED Plasmodium yoelii 1115 126717 MEDl IIDEIIKFYAKK QLNKELGYGQKL KTQ 68... 

LDMS is particularly well suited for the analysis of porphyrins.35-39 The heme molecule—a 22 rc-electron conjugated protoporphyrin system (Figure 8.1)—is an efficient photo-absorber in the visible and near UV (with an absorption maximum—the Soret band—near 400nm). This feature, concurrently with its low ionization potential, warrants that direct LDMS will possess extremely low limits for heme detection. The uses of IR or UV LDMS for structural characterization of natural porphyrins and their metabolites, synthetic monomeric porphyrins (e.g., used in photodynamic therapy), porphyrin polymers, and multimeric arrays, have been well documented.41148 In addition fast atom bombardment MS has been used to characterize purified hemozoin, isolated from the spleens and livers of Plasmodium yoelii infected mice.49... 

Carlton, J. M. et al. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii. Nature 2002, 419,512-519. 

Pandey, A. Tekwani, B. Pandey, V. Characterization of hemozoin from liver and spleen of mice infected with Plasmodium yoelii, a rodent malaria parasite. Biomed. Res. 1995,16,115-120. 

Host resistance Bacterial models—Listeria monocytogenes (mortality or spleen clearance) Streptococcus species (mortality) Viral models—influenza (mortality) Parasitic models—Plasmodium yoelii (parasitemia) or Trichinella spiralis (muscle larvae counts and worm expulsion) Syngeneic tumor models—PYB6 sarcoma (tumor incidence) B16F10 melanoma (lung burden). 

Most studies have concentrated on the synthesis of new active artemisinin analogs. A series of highly lipophilic ether derivatives have been prepared and tested and the two most active compounds 311a,b provided 100% protection to Plasmodium yoelii nigeriensis infected mice <2006JME7227>. 

Hydroxy-N-methylseverifoline Growth inhibition of Plasmodium yoelii 10 /Ag/ml 307... 

Taylor DW, Levander OA, Krishna VR, Evans CB, Morris VC, Barta JR. Vitamin E-deficient diets enriched with fish oil suppress lethal Plasmodium yoelii infections in athymic and scid/bg mice. Infect. Immun. 1997 65 197-202. 

Pefloxacin is a fluoroquinolone antibiotic that inhibits Plasmodium falciparum in vitro. It is effective against Plasmodium yoelii infections in mice. 

Brinkmann V, Kaufmann SH, Simon MM, et al Role of Macrophages in Malaria 02 Metabolite Production and Phagocytosis by Splenic Macrophages During Lethal Plasmodium berghei and Self-limiting Plasmodium yoelii Infection in Mice. Infect. Immun. 1984 44(3) 7434. 

Baer, K., Klotz, C., Kappe, S. H., Schnieder, T., and Frevert, U. (2007a). Release of hepatic Plasmodium yoelii merozoites into the pulmonary microvasculature. PLoS Pathog. 3, el71. 

Gati, W. P., Stoyke, A. F., Gero, A. M., and Paterson, A. R. (1987). Nucleoside permeation in mouse erythrocytes infected with Plasmodium yoelii. Biochem. Biophys. Res. Commun. 145, 1134 1141. 

Gautret, P., Miltgen, F., Chabaud, A. G., and Landau, I. (1996). Synchronized Plasmodium yoelii yoeliv. Pattern of gametocyte production, sequestration and infectivity. Parassitologia 38, 575-577. 

Howard, R. J., Smith, P. M., and Mitchell, G. F. (1980). Characterization of surface proteins and glycoproteins on red blood cells from mice infected with haemosporidia Plasmodium yoelii infections of BALB/c mice. Parasitology 81, 299-314. 

Kicska, G. A., Ting, L. M., Schramm, V. L., and Kim, K. (2003). Effect of dietary p-amino-benzoic acid on murine Plasmodium yoelii infection. J. Infect. Dis. 188,1776-1781. 

Labaied, M., Harupa, A., Dumpit, R. F., Coppens, I., Mikolajczak, S. A., and Kappe, S. H. (2007b). Plasmodium yoelii sporozoites with simultaneous deletion of P52 and P36 are completely attenuated and confer sterile immunity against infection. Infect. Immun. 75, 3758-3768. 

Sinden, R. E., and Croll, N. A. (1975). Cytology and kinetics of microgametogenesis and fertilization in Plasmodium yoelii nigeriensis. Parasitology 70,53-65. 

Singh, S., Puri, S. K., Singh, S. K., Srivastava, R., Gupta, R. C., and Pandey, V. C. (1997). Characterization of simian malarial parasite (Plasmodium knowlesi)-]nd uced putrescine transport in rhesus monkey erythrocytes. A novel putrescine conjugate arrests in vitro growth of simian malarial parasite (Plasmodium knowlesi) and cures multidrug resistant murine malaria (Plasmodium yoelii) infection in vivo. J. Biol. Chem. Til, 13506-13511. 

Wang, Q., Brown, S., Roos, D. S., Nussenzweig, V., and Bhanot, P. (2004c). Transcriptome of axenic liver stages of Plasmodium yoelii. Mol. Biochem. Parasitol. 137,161-168. 

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