Jatrorrhizine chloride

Jatrorrhizine chloride exhibited reverse transcriptase inhibitory properties against both HIV-1RT (p66/p51 XHuman immunodeficiency virus type 1 reverse transcriptaseXICjg 42.4 pg/ml [113.4 pM]) and HIV-2RT (p68/p55)(Human immunodeficiency virus type 2 reverse transcriptase)(IC 0 39.8 pg/ml [106.5 pM]). The alkaloid is thought to inhibit various RNA and DNA polymerizing enzymes via interaction with nucleic acid template-primers [212]. 

Jatrorrhizine chloride was evaluated for antimalarial activity against Plasmodium falciparum in vitro (two clones of human malaria Plasmodium falciparum D-6 [Sierra Leone clone] and W-2 (Indochina clone) and Plasmodium berghei in vivo (mice). The alkaloid exhibited an antimalarial potency equivalent to that of quinine in vitro, but was inactive in vivo [228],... 

Jatrorrhizine chloride was evaluated in the human immunodeficiency virus reverse transcriptase assay and found to be moderately active (50 pg/ml < ICJ0 < 150 pg/ml)[229]. 

Jatrorrhizine (Jateorhizine). (Items 6, 9, 11, 14, 18, 19, 21, 22 list, p. 329.) The iodide, C20H20O4NI. H2O, crystallises in reddish-yellow needles, m.p. 210-2° the chloride C20H20O4NCI. H2O, forms copper-coloured needles, m.p. 206°, and the nitrate golden-yellow needles, m.p. 225° (dec.). On 0-methylation, jatrorrhizine iodide yields palmatine iodide, and on reduction it is converted into dZ-tetrahydrojatrorrhizine, m.p. 217-8°, the d-form of which is corypalmine and which on 0-methylation yields tetrahydropalmatine (p. 292). ... 

T. revolutum D.C. [1] p-Allocryptopine Argemonine Berberine Bisnorthalphenine Choline chloride Columbamine A -Desmethylthalphenine Deoxythalidastine Eschscholtzidine Isonorargemonine Jatrorrhizine Laudanidine Magnoflorine /V-Methylargemonine A-Methylarmepavine Af-Methylcoclaurine... 

Palmatine, berberine, and jatrorrhizine were isolated as chlorides from the former and pahnatine from the latter 19). 

Quaternary protoberberine chlorides, including berberine, palmatine, jatrorrhizine, coptisine, and dehydrocorydaline, cause marked contraction of uterine muscle, but only weak spasmolytic activity on isolated mouse intestine. Protoberberine alkaloid bearing plants which exhibit abortifacient and uterine stimulant properties have been reviewed by Farnsworth and co-workers." ... 

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