Gene-silencing

Page, J.E. et al., Functional analysis of the final steps of the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway to isoprenoids in plants using virus-induced gene silencing, Plant Physiol. 134, 1401, 2004. [Pg.389]

In addition to histone deacetylation, histone lysine methylation can also lead to gene silencing which is not blocked by the HDAC inhibitors [6, 51], Several lines of evidence have suggested a connection between cancer and histone lysine methyltrans-ferases (HKMTs) [52], HKMTs catalyze the transfer of methyl group(s) from the cofactor. S -adenosyI-methionine (AdoMet) to some specific lysine residues in the N-terminal histone tails [53, 54], With one exception of Dotl [55], all known HKMTs contain the SET domain which represents a novel structural fold [53, 56], Among SET-domain HKMTs, SET7/9 is one of the best characterized experimentally. It is a... [Pg.345]

Shaklai, S, N Amariglio, G Rechavi, and AJ Simon. 2007. Gene silencing at the nuclear periphery. FEBS J... [Pg.463]

Kim, D. H., Villeneuve, L. M., Morris, K. V., and Rossi, J. J. (2006). Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells. Nat. Struct. Mol. Biol. 13, 793-797. [Pg.145]

Aigner A (2006) Gene silencing through RNA interference (RNAi) in vivo strategies based on the direct application of siRNAs. J Biotechnol 124 12-25... [Pg.19]

Zhou J, Wu J, Hafdi N, Behr JP, Erbacher P, Peng L (2006) PAMAM dendrimers for efficient siRNA delivery and potent gene silencing. Chem Commun (Camb) 2006 2362-2364... [Pg.20]

RNAi and ribozymes represent two additional approaches to gene silencing/down-regulation with therapeutic potential. RNAi is an innate cellular process that achieves silencing of selected genes via an anti-sense mechanism. It shares many characteristics with the antisense-based approach described above, but also some important differences, e.g. in the exact mechanism by which the antisense effect is achieved. [Pg.451]

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