Peripheral blood cells

TNE- a also protects mice against the lethal effects of radiation (164). TNE- a given before sublethal kradiation reduces the decline of neutrophils and total blood counts and accelerates the recovery of peripheral blood cells (190). TNE- a also alters the radiosensitivity of murine G1 progenitors (191). 

Cornetta K, Croop J, Dropcho E, Abonour R, Kieran MW, Kreissman S, Reeves L, Erickson LC, Williams DA (2006) A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34-I- peripheral blood cells with 06-methylguanine DNA methyltransferase. Cancer Gene Ther 13 886-895... 

Foster B, Schwartz LB, Devouassoux G, Metcalfe DD, Prussin C Characterization of mast-cell try-ptase-expressing peripheral blood cells as basophils. J Allergy Clin Immunol 2002 109 287-293. Schwartz LB, Bradford TR, Rouse C, Irani AM, Rasp G, Van der Zwan JK, Van del Linden PW Development of a new, more sensitive immunoassay for human tryptase use in systemic anaphylaxis. J Clin Immunol 1994 14 190-204. 

Benhammou, K.L.M., Strook, M.A., Sullivan, B., Logel, J., Raschen, K., Gotti, C., Leonard, S. [3H] nicotine binding in peripheral blood cells of smokers is correlated with the number of cigarettes smoked per day. Neuropharmacology. 39 2818, 2000. 

For carrying out fundamental research in this direction, the model (biotestsystem), based on the cocultivation of the peripheric blood cells of the Humans with the various infection diseases agents such as Diphtheria, Tularemia, Tuberculosis, Cholera, HIV-infection is developed [7],... 

Unexplained alterations in peripheral blood cell lines or histopathologic findings might suggest that cytologic evaluation of the bone marrow would be appropriate. 

Baj Z, Majewska E, Zeman K, et al. 1994. The effect of chronic exposure to formaldehyde, phenol and organic chlorohydrocarbons on peripheral blood cells and the immune system in humans. J Invest Allergol Clin Immunol 4 186-191. 

The in vivo micronucleus test is used for the detection of damage to chromosomes as well as the mitotic apparatus in bone marrow or peripheral blood cells of rodents. The assay system has been well standardized.14-17 The basic features of the test system are (1) the effect of the test chemical is observed in anucleated polychromatic erythrocytes (PCEs) (2) PCEs have a relatively short lifespan, so that any micronuclei they contain must have been generated as a result of recently induced chromosome damage (3) micronuclei are readily identifiable and their distribution is well defined and (4) the frequency of induced micronuclei in PCEs is dependent on sampling times. 

Studies performed at RCRM have shown that hematopoietic and immune systems reconstitution after irradiation depends greatly on the functional abilities of the stem cells. Subset analysis and expression of CD34-i- antigens on bone marrow and peripheral blood cells were studied in Chernobyl accident clean-up workers including patients with leukemia and myelodysplasia and patients exposed to the natural levels of irradiation (table 2). 

Benbassat J (1974) The transition from tadpole to frog haemoglobin during natural amphibian metamorphosis. I. Protein synthesis by peripheral blood cells in vitro. J Cell Sci 15 347-357... 

Several studies have shown no evidence of mutagenicity or teratogenicity. Chromosome damage was induced in bone marrow cells of rats by intraperitoneal injection of 10-50mg/kg per day for 5 days and in peripheral blood cells of fetal lambs treated in utero with 50-250mg/%. °... 

Except for the treatment of acute nonlymphocytic leukemia, mitoxantrone therapy generally should not be given to patients with baseline neutrophil counts less than 1500 cells/mm. In order to monitor the occurrence of bone marrow suppression, primarily neutropenia, which may be severe and result in infection, it is recommended that frequent peripheral blood cell counts be performed on all patients receiving mitoxantrone. 

Hematotoxicity, defined as drug-induced altered production of peripheral blood cells, is most commonly associated with antiproliferative oncology compounds but is also caused by drugs for various indications, covering a wide pharmacology and chemical structure diversity (Table 17.1). This vast variety of chemical structures makes it difficult to predict hematotoxicity by in silica approaches and to model... 

In vivo in mouse liver, DNA strand breaks were induced by 1,2-dichloroethane after intraperitoneal injection or oral exposure but not after inhalation. DNA single strand-breaks were also obserx-ed in liver cells after gavage of rats. In vivo in mice, single studies with the spot test and sister chromatid exchange were inconclusive and positive, respectively no micronuclei were found in bone marrow or peripheral blood cells of mice. 

Methyl bromide induced micronuclei in bone-marrow and peripheral blood cells of rats and mice. 

MVM, Mieronueleus test, Tg.AC mouse peripheral blood cells in vivo - 12 pg/mouse skin Tice et al. (1997)... 

Gessi S, Cattabriga E, Avitabile A, Gafa R, Lanza G, Cavazzini L, Bianchi N, Gambari R, Feo C, Liboni A, Gullini S, Leung E, Mac Lennan S, Borea PA (2004) Elevated expression of A3 adenosine receptors in human colorectal cancer is reflected in peripheral blood cells. Clin Cancer Res 10(17) 5895-5901... 

Verthelyi, D., Ishii, K., Gursel, M., Takeshita, F. and Klinman, D. (2001) Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol., 166,2372-2377. 

Fig. 6.9. Peripheral blood cells from a normal volunteer, a patient receiving chemotherapy, and a patient with B-cell leukemia. Normal cells appear as a tight cluster of lymphocytes with a diffuse group of monocytes on their shoulder possessing brighter FSC and SSC and a large cluster of cells with high SSC (neutrophils). The patient receiving chemotherapy has clusters in similar positions, but with far fewer lymphocytes that merge at their top end into the monocytes. The leukemic patient s cells are almost exclusively lymphocytes, which have slightly lower FSC than normal cells. Data files were provided by Marc Langweiler and Sharon Rich.

Patients, suffering apparently from the same type of tumor, often respond differently to Pt-chemotherapy. Therefore, a research program has been started on the Pt-adduct formation and repair in the DNA of the nucleated peripheral blood cells of these patients. Figure 22 shows the number of intrastrand crosslinks on pGG sequences per 109... 

Oughton JA, Pereira CB, DeKrey GK, et al. 1995. Phenotypic analysis of spleen, thymus, and peripheral blood cells in aged C57BL/6 mice following long-term exposure to... 

Tracy PB, Eide LL, Mann KG. Human prothrombinase complex assembly and function on isolated peripheral blood cell populations,] Biol Chem 1985 260 21 19-2124. 

Brunner, G., Nguyen, H., Gabrilove, J., Rifkin, D.B., and Wilson, E.L. 1993. Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells. Blood 81 631-638. 

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