Peripheral blood stem cell analysis

Anonymous. Allogeneic peripheral blood stem-cell compared with bone marrow transplantation in the management of hematologic malignancies An individual patient data meta-analysis of nine randomized trials. J Clin Oncol 2005 23 5074-5087. 

Murata M, Harada M, Kato S, Takahashi S, Ogawa H, Okamoto S, Tsuchiya S, Sakamaki H, Akiyama Y, Kodera Y. Peripheral blood stem cell mobilization and apheresis analysis of adverse events in 94 normal donors. Bone Marrow Transplant 1999 24(10) 1065-71. 

Currently, there is no published literature documenting health outcome or economic benefits provided by a pharmacist to a bone marrow transplant patient. There are several review articles analyzing the economics of bone marrow transplant, peripheral blood stem cell transplant, and outpatient-based transplant.The articles refer to various detailed cost-effective and cost-minimization studies. Unfortunately, they do not breakdown the cost analysis studies to note the impact a pharmacist has on the total cost of a bone marrow transplant procedure. The input provided by a pharmacist to the bone marrow transplant team is substantial and necessary for a cancer center to remain competitive and fiscally responsible. There is a strong need for bone marrow transplant pharmacists to generate outcome data and collectively or individually publish the benefits of retaining a pharmacist on the bone marrow transplant team. 

Cutler C, Giri S, Jeyapalan S, et al. Acute and chronic graft-versus-host disease after allogeneic peripheral blood stem cell and bone marrow transplantation A meta-analysis. J CUn Oncol 2001 19 3685-3691. 

Magagnoli, M., Masci, G., Castagna, L., et al., 2006. Prophylaxis of central venous catheter-related thrombosis with mini dose warfarin in patients treated with high-dose chemotherapy and peripheral-blood stem cell transplantation retrospective analysis of 228 cancer patients. Am. J. Hematol. 81 (1), 1-4. 

Studies performed at RCRM have shown that hematopoietic and immune systems reconstitution after irradiation depends greatly on the functional abilities of the stem cells. Subset analysis and expression of CD34-i- antigens on bone marrow and peripheral blood cells were studied in Chernobyl accident clean-up workers including patients with leukemia and myelodysplasia and patients exposed to the natural levels of irradiation (table 2). 

In conclusion, clonality analysis is fundamental criteria for the diagnosis of many types of lymphoma and an essential tool for the differentiation between lymphoma and other benign or unclassified hyperplasic lymphoid lesions or pseudolymphoma. Additionally clonality analysis is also useful for the screening of bone marrow before autologous bone marrow or stem cell transplantation or for the detection of minimal residual disease in bone marrow and peripheral blood. 

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