Human bone marrow

Broxmeyer HE, Sherry B, Lu L, et al. Myelopoietic enhancing effects of murine macrophage inflammatory proteins 1 and 2 on colony formation in vitro by murine and human bone marrow granulocyte/macrophage progenitor cells. J Exp Med... 

Fedyk ER, Ryyan DH, Ritterman I, Springer TA. Maturation decreases responsiveness of human bone marrow B lineage cells to stromal-derived factor 1 (SDF-1). J Leukoc Biol 1999 66(4) 667-673. 

Honczarenko M, Douglas RS, Mathias C, Lee B, Ratajczak MZ, Silberstein LE. SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells. Blood 1999 94(9) 2990-2998. 

Conti, A., Conconi, S., Hertens, E. et al. (2000). Evidence for melatonin synthesis in mouse and human bone marrow cells. J. Pineal Res. 28, 193-202. 

Schweitzer KM, Vicart P, Delouis C, Paulin D, Drager AM, Langenhuijsen MM, Weksler BB. Characterization of a newly established human bone marrow endothelial cell line distinct adhesive properties for hematopoietic progenitors compared with human umbilical vein endothelial cells. Lab Invest 1997 76 25-36. 

Tao, H. and Ma, D. D. Evidence for transdifferentiation of human bone marrow-derived stem cells recent progress and controversies. Pathology 35 6-13,2003. 

Devlin RD, Reddy SV, Savino R, Ciliberto G, Roodman GD (1998) IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or l,25(OH)2D3, on osteoclast-like cell formation in normal human bone marrow cultures. J Bone Miner Res 13 393-399... 

C4. Chackal-Roy, R. M., Niemeyer, C., More, M., and Zetter, B. R., Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow. J. Clin. Invest. 84, 43-50 (1989). 

When the nitroso analogue became available131 this hypothesis was tested experimentally. Nitroso-CAP has proved to be considerably more toxic to cultured human bone marrow cells than CAP and to irreversibly inhibit DNA synthesis as well as the growth of... 

Three years later, Lajtha, Oliver, and Ellis performed similar studies with human bone-marrow cultures exposed to 32P, or 14C-adenine. Control smears were treated with M HC1 at 60 °C for 6.5 min to remove 32P not incorporated into DNA. Grain counts were made over individual nuclei so that the rate of uptake into DNA could be estimated. The cycle time for the dividing cells in the culture was 40-48 h. DNA synthesis took 12-15 h in the second half of the cycle and was divided from mitosis by a 3-4 h non-synthesizing period (G2). 

Lajtha, L.G., Oliver, R., Ellis, F. (1954). Incorporation of 32P and 14C adenine into DNA by human bone-marrow cells in vitro. Brit. J. Cancer 8, 367-399. 

Kocher, A.A., Schuster, M.D., Szabolcs, M.J., Takuma, S., Burkhoff, D., Wang, J., Homma, S., Edwards, N.M. and Itescu, S. (2001). Neovascularization of ischemic myocardium by human bone marrow derived angioblasts prevents cardiomyoc34e apoptosis, reduces remodeling and improves cardiac function. Nat Med 7, 430-446. 

Quirici N, Soligo D, Caneva L, Servida E, Bossolasco P, Deliliers GL. Differentiation and expansion of endothelial cells from human bone marrow CD133( +) cells. BrJ Haematol 2001 115 186-194. 

Fernandez-Aviles F, San Roman JA, Garcia-Frade J, Fernandez ME, Penarrubia MJ, de la Fuente L, Gomez-Bueno M, Cantalapiedro A, Fernandez J, Gutierrez O, Sanchez PL, Hernandez C, Sanz R, Garcia-Sancho J, Sanchez A. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Cite Res 2004 95 742-748. 

Pereira, A. and Dean, B. (2006) Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells a potential in vitro system for the study of agranulocytosis. Biochemical Pharmacology, 71, 783—793. 

Coumarin was not toxic at concentrations up to 100 pg/mL to human peripheral blood mononuclear cells in vitro. Coumarin and its metabolite, 7-hydroxycoumarin, produced significant suppression of human bone marrow progenitor stem cell activity at concentrations greater than 200 pg/mL, whereas coumarin concentrations of 25 pg/mL and above produced suppression of murine bone marrow progenitor stem cell activity (Gallicchio et al., 1989). 

Fig. 2.4. Human bone marrow smear, stained with Wright-Giemsa s stain (a) transmission acoustic, 900 MHz (b) transmitted light (Lemons and Quate 1979).

Adhesion of mononuclear cells from human bone marrow aspirates (BM-MNC) to tissue culture plastic and removal of nonadherent cells during the first days of culture selects for a population of proliferating spindle-shaped fibroblast-like non-... 

Miao, Z., Jin, J., Chen, L., et al. (2006), Isolation of mesenchymal stem cells from human placenta Comparison with human bone marrow mesenchymal stem cells, Cell. Biol. Int., 30(9), 681-687. 

Lazarus, H. M., Haynesworth, S. E., Gerson, S. L., Rosenthal,N. S., and Caplan,A. I. (1995), Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells) Implications for therapeutic use, Bone Marrow Transplant., 16(4), 557-564. 

Colter, D. C, Class, R., DiGirolamo, . M., Prockop, D. J. (2000), Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow, Proc. Nat. Acad. Sci. USA, 97(7), 3213-3218. 

Wagner, W., Wein, F., Seckinger, A., et al. (2005), Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood, Exp. Hematol., 33(11), 1402-1416. 

Monticone, M., Liu, Y.,Tonachini, L., et al. (2004), Gene expression profile of human bone marrow stromal cells determined by restriction fragment differential display analysis, /. Cell. Biochem, 92(4), 733-744. 

Di Nicola, M., Carlo-Stella, C., Magni, M., et al. (2002), Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli, Blood, 99(10), 3838-3843. 

Chen, J., Li, Y., Zhang, R., Katakowski, M., Gautam, S.C., Xu, Y., Lu, M., Zhang, Z., Chopp, M. (2004). Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis. Brain Res, 1005,21-8. 

CIH, Chromosome aberrations, human bone-marrow cells in vitro (+) NT 0.1 Marx et al. (1983)... 

Maniglier-Poulet. C.. Cheng, X., Ruth, J.A. Ross, D. (1995) Metabolism of 1,3-butadiene to butadiene monoxide in mouse and human bone marrow cells. Chem.-biol. Interact., 91, 119-129... 

Catechol may be oxidized by peroxidases to the reactive intennediate benzo-1,2-quinone, which readily binds to proteins (Bhat et al., 1988) this process, catalysed by rat or human bone-marrow cells in the presence of H2O2 (0.1 mM), is stimulated by phenol (0.1-10 mM), and decreased by hydroquinone and by glutathione, which conjugates with benzo-l,2-quinone. These phenols (phenol, catechol and hydroquinone) may play a role in benzene toxicity to bone marrow all three are formed as benzene metabolites (Smith et al., 1989) and they interact in several ways as far as their bioactivation by (myelo)peroxidases is concerned (Smith et al., 1989 Subrahmanyam et al., 1990). 

Bhat. R.V. Subrahmanyam, y.y., Sadler, A., Ross, D. (1988) Bioactivation of catechol in rat and human bone marrow cells. Toxicol, appl. Pharmacol, 94, 297-304... 

Moran, J.L., Siegel, D., Sun, X.-M. Ross, D. (1996) Induction of apoptosis by benzene metabolites in HL60 and CD34 human bone marrow progenitor cells. Mol. Pharmacol., 50, 610-615... 

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