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Nicotine binding

The nAChR subtypes vary in response to pharmacological manipulation. The a7 receptors have a low affinity for nicotine and are sensitive to a-bungarotoxin (a-BTX) antagonism, whereas the heteromeric nAChRs are not.14 The p2 containing (p2 asterisk denotes the presence of additional subunits) nAChRs have the highest affinity for nicotine binding and some selectivity for antagonism... [Pg.24]

Benhammou, K.L.M., Strook, M.A., Sullivan, B., Logel, J., Raschen, K., Gotti, C., Leonard, S. [3H] nicotine binding in peripheral blood cells of smokers is correlated with the number of cigarettes smoked per day. Neuropharmacology. 39 2818, 2000. [Pg.47]

Benwell, M., Balfour, D., Anderson, J. Evidence that tobacco smoking increases the density of (—)-pH]nicotine binding site in human brain. J. Neurochem. 50 1243, 1988. [Pg.47]

Breese, C., Marks, M., Logel, J. et al. Effect of smoking history on [3H]nicotine binding in human postmortem brain. J. Pharmacol. Exp. Then 282 7, 1997. [Pg.47]

Marks, M., Pauly, J., Gross, S. et al. Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J. Neurosci. 2765, 1992. [Pg.48]

Lebargy, F. et al., Tobacco smoking induces expression of very-high-affinity nicotine binding sites on blood polymorphonuclear cells, Am. J. Respir. Crit. Care Med., 153,1056,1996. [Pg.539]

Costa LG, Murphy SD. 1983a. [3H]Nicotine binding in rat brain Alterations after chronic acetylcholinesterase inhibition. J Pharmacol Exp Ther 226 392-397. [Pg.181]

Abdulla FA, Bradbury E, Calaminici MR, Lippiello PM, Wonnacott S, Gray JA, Sinden JD. (1996). Relationship between up-regulation of nicotine binding sites... [Pg.445]

London ED, Waller SB, Wamsiey JK. (1985). Autoradiographic localization of [3H] nicotine binding sites in the rat brain. Neurosci Lett. 53 179-84. [Pg.526]

Bhat RV, Marks Ml, Collins AC (1994) Effects of chronic nicotine infusion on kinetics of high-afHnity nicotine binding. 1 Neurochem 62 574-581... [Pg.105]

Chen DN, Patrick JW (1997) The a-bungarotoxin-binding nicotinic acetylcholine receptor from rat brain contains only the a7 subunit, J Biol Chem 272 24024-24029 Clarke PBS, Schwartz RD, Paul SM, Pert CB, Pert A (1985) Nicotinic binding in rat brain autoradiographic comparison of [ H]acetylcholine, [ H]nicotine, and [ I]-alpha-bungarotoxin, J Neurosci 5 1307-1315... [Pg.106]

Lippiello PM, Sears SB, Fernandes KG (1987) Kinetics and mechanism of L-[ H]nicotine binding to putative high affinity receptor sites in rat brain. Mol Pharmacol 31 392-400... [Pg.108]

Marks Ml, Collins AC (1982) Characterization of nicotine binding in mouse brain and comparison with the binding of a-bungarotoxin and quinuclidinyl benzilate. Mol Pharmacol 22 554-564 Marks Ml, Burch JB, Collins AC (1983) Effects of chronic nicotine infusion on tolerance development and nicotinic receptors. J Pharmacol Exp Ther 226 817-825 Marks Ml, Stitzel JA, Romm E, Wehner JM, Collins AC (1986) Nicotinic binding sites in rat and mouse brain comparison of acetylchohne, nicotine, and alpha-bungarotoxin. Mol Pharmacol 30 427 36... [Pg.109]

Marks Ml, Campbell SM, Romm E, Collins AC (1991) Genotype influences the development of tolerance to nicotine in the mouse. J Pharmacol Exp Ther 259 392 02 Marks MJ, Pauly JR, Gross SD, Deneris ES, Hermans-Borgmeyer I, Heinemann SF, Collins AC (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci 12 2765-2784... [Pg.109]

Whiteaker P, Peterson CG, Xu W, McIntosh JM, Paylor R, Beaudet AL, Collins AC, Marks MJ (2002) Involvement of the alpha3 subunit in central nicotinic binding populations, J Neurosci 22 2522-2529... [Pg.112]

The most parsimonious model for upregulation that acconunodates current information suggests that nicotine binding to inunature subnnits enhances receptor assembly by provoking quaternary structure rearrangements (that might resnlt in altered subunit stoichiometry), leading to accelerated maturation of nAChRs and a net... [Pg.193]

Fig. 4 Current model for nicotine upregulation of a4p2 nAChRs. a Schematic of a ceU indicating major steps in the lifecycle of a nAChR. Nicotine accumulates within the cell. Within the endoplasmic reticulum, nicotine binds to nAChR subunits to facilitate assembly, or binds at the interface of an aP subunit pair to enhance maturation of a pentameric nAChR (Sallette et al. 2004, 2005). The strong influence of nicotine on maturation of the P2 subunit might also favour a change in nAChR stoichiometry, from (a4)3(P2)2 to (a4)2(P2)3 (Moroni et al. 2006). These actions could result in an increase in the membrane insertion of competent nAChRs. The possibflity of an additional action of nicotine to impede nAChR turnover or degradation is indicated by the dotted line, b Binding of nicotine to the extracellular domain of unassembled nAChR subunits facilitates assembly, c Binding of nicotine at an aP interface facilitates maturation of a pentameric nAChR. Items b and c adapted from Nashmi and Lester (2007), with permission from Elsevier... Fig. 4 Current model for nicotine upregulation of a4p2 nAChRs. a Schematic of a ceU indicating major steps in the lifecycle of a nAChR. Nicotine accumulates within the cell. Within the endoplasmic reticulum, nicotine binds to nAChR subunits to facilitate assembly, or binds at the interface of an aP subunit pair to enhance maturation of a pentameric nAChR (Sallette et al. 2004, 2005). The strong influence of nicotine on maturation of the P2 subunit might also favour a change in nAChR stoichiometry, from (a4)3(P2)2 to (a4)2(P2)3 (Moroni et al. 2006). These actions could result in an increase in the membrane insertion of competent nAChRs. The possibflity of an additional action of nicotine to impede nAChR turnover or degradation is indicated by the dotted line, b Binding of nicotine to the extracellular domain of unassembled nAChR subunits facilitates assembly, c Binding of nicotine at an aP interface facilitates maturation of a pentameric nAChR. Items b and c adapted from Nashmi and Lester (2007), with permission from Elsevier...
Observed increased nicotine binding ranging from 20-50%, with a mean value of around 30% . . changes in... [Pg.474]

See other pages where Nicotine binding is mentioned: [Pg.326]    [Pg.40]    [Pg.40]    [Pg.41]    [Pg.41]    [Pg.41]    [Pg.61]    [Pg.184]    [Pg.34]    [Pg.90]    [Pg.93]    [Pg.94]    [Pg.95]    [Pg.95]    [Pg.96]    [Pg.98]    [Pg.155]    [Pg.163]    [Pg.167]    [Pg.174]    [Pg.175]    [Pg.197]    [Pg.201]    [Pg.418]    [Pg.473]    [Pg.509]    [Pg.268]   
See also in sourсe #XX -- [ Pg.90 , Pg.93 , Pg.94 , Pg.95 , Pg.98 , Pg.418 ]

See also in sourсe #XX -- [ Pg.450 ]



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