Hematotoxicity prediction

Hematotoxicity, defined as drug-induced altered production of peripheral blood cells, is most commonly associated with antiproliferative oncology compounds but is also caused by drugs for various indications, covering a wide pharmacology and chemical structure diversity (Table 17.1). This vast variety of chemical structures makes it difficult to predict hematotoxicity by in silica approaches and to model... 

Qualification of the tier 1 assays with the limited number of compounds indicated that the cell lines were able to predict the in vivo hematotoxicity potential of compounds, but further qualification using more compounds and specifically noncytotoxic compounds are still required. 

Krishnan K, Pelekis M. 1995. Hematotoxic interactions occurrence, mechanisms and predictability. Toxicology 105 355-364. 

Several NSAIDs, including aspirin, ibuprofen, and piroxicam, increase serum levels of methotrexate by interfering with its renal clearance. The adverse effects of methotrexate, including its hematotoxicity are predictably increased. The answer is (J). 

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