Autologous peripheral blood stem cell transplantation

Harter C, Schulze B, Goldschmidt H, Benner A, Geiss HK, Hoppe-Tichy T et al. Piperachlin/tazobactam vs ceftazidime in the treatment of neutropenic fever in patients with acute leukemia or foUowing autologous peripheral blood stem cell transplantation a prospective randomized trial. Bone Marrow Transplant 2006 37 373-79. 

Reichardt, V. L., Okada, C. Y, Liso, A., Benike, C. J., Stockert-Goldstein, K. E., Engleman, E. G., Blume, K. G., and Levy, R. 1999. Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma A feasibility study. Blood 93 2411-2419. 

Garrido SM, Chauncey TR. Neuroleptic malignant syndrome following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 1998 21(4) 427-8. 

Colby C, McAfee S, Sackstein R, Finkelstein D, Fishman J, Spitzer T. A prospective randomized trial comparing the toxicity and safety of atovaquone with trimethoprim/sulfamethoxazole as Pneumocystis carinii pneumonia prophylaxis following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 1999 24(8) 897-902. 

Sawada M, Tsurumi H, Kara T, Goto H, Yamada T, Oyama M, Moriwaki H. Graft failure of autologous peripheral blood stem cell transplantation due to acute metabohc acidosis associated with total parenteral nutrition in a patient with relapsed breast cancer. Acta Haematol 2000 102(3) 157-9. 

Between September 1995 and November 2000, 70 patients were vaccinated after autologous peripheral blood stem cell transplantation (ASCT ) with one of two formulations of Theratope (Biomira, Edmonton, Alberta, Canada) coupled with Detox B SE (Detox B) (Corixa, Hamilton, MT). The difference between the two formulations was that the later one has an increased ratio of STn conjugated to KLH compared to the first formulation. The vaccination schedule for the two different formulations was previously published as well as medical treatment history of ASCT patients 18). 

Nash RA, Bowen JD, McSweeney PA, et al. High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation in severe multiple sclerosis. Blood 2003 102 2364-2372. 

Krause SW, Rothe G, Gnad M, Reichle A, Andreesen R (2003) Blood leukocyte subsets and cytokine profile after autologous peripheral blood stem cell transplantation. Ann He-matol 82 628-636... 

Kessinger A, Schmit-Pokorny K, Smith D, Armitage J. Cryopreservation and infusion of autologous peripheral blood stem cells. Bone Marrow Transplant 1990 5(Suppl l) 25-7. 

Fuchs M, Scheid C, Schulz A, Diehl V, Sohngen D. Trimethoprim/sulfamethoxazole prophylaxis impairs function of mobilised autologous peripheral blood stem cells. Bone Marrow Transplant 2000 26(7) 815-16. 

Kessinger A, Armitage JO, Landmark JD, et al. Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy. Blood 1988 71 723-727. 

PBSCs Peripheral blood stem cells hematopoietic cells found in peripheral blood that have the capability to give rise to several different types of mature blood cells. PBSCs are used for autologous transplantation (transplantation with one s own cells) and allogeneic transplantation (transplantation with someone etse s cells)... 

Twenty months after finishing her chemotherapy, the woman had a relapse of breast cancer. The cancer was now unresponsive to standard doses of chemotherapy. The decision was made to treat the patient with high-dose chemotherapy followed by autologous stem cell transplantation. Which of the following drugs is most likely to be used to mobilize the peripheral blood stem cells needed for the patient s autologous stem cell transplantation ... 

The success of transplantation with peripheral blood stem cells depends upon infusion of adequate numbers of hematopoietic stem cells. Administration of G-CSF to the donor (in the case of autologous transplantation, the patient who also will be the recipient of the transplantation) greatly increases the number of hematopoietic stem cells harvested from the donor s blood and available for the transplantation procedure. The answer is (B). 

Dreger P, Kloss M, Petersen B, Haferlach T, et al. 1995. -Autologous progenitor cell transplantation Prior exposure to stem cell-toxic drugs determines yield and engraft-ment of peripheral blood progenitor cell but not of bone marrow grafts. Blood. 86 3970-3978. 

In conclusion, clonality analysis is fundamental criteria for the diagnosis of many types of lymphoma and an essential tool for the differentiation between lymphoma and other benign or unclassified hyperplasic lymphoid lesions or pseudolymphoma. Additionally clonality analysis is also useful for the screening of bone marrow before autologous bone marrow or stem cell transplantation or for the detection of minimal residual disease in bone marrow and peripheral blood. 

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