Peripheral blood progenitor cell mobilization

Leukine Sargramostim (GM-CSF) Immunex Autologous bone marrow transplantation, neutropenia resulting from chemotherapy, peripheral blood progenitor cell mobilization, and transplantation... 

Autologous bone marrow transplant Neutropenia resulting from chemotherapy Allogeneic bone marrow transplant Peripheral blood progenitor cell mobilization Leukemias (leukopenias and fungal infection) March 1991 Sept. 1995 Nov. 1995 Dec. 1995 Nov. 1996... 

Support for peripheral blood progenitor cell mobilization and transplantation Becaplermin Lower extremity diabetic neuropathic ulcers... 

Reddy RL. Mobilization and collection of peripheral blood progenitor cells for transplantation. Transfus Apher Sci 2005 32 63-72. 

Stem cell transplantation Mobilization of peripheral blood progenitor cells (PBPCs) Patients with nonmyeloid malignancies treated with stem cell transplantation... 

Mobilization of peripheral blood progenitor cells (PBPCs)... 

Epoetin combined with parenteral iron is effective and safe for moderate and severe iron deficiency anemia during pregnancy (26), and iron supplementation is often required (27). The use of epoetin in combination with intravenous iron makes collection of larger numbers of autologous erythrocyte units feasible. However, epoetin does not synergize with G-CSF for the mobilization of peripheral blood progenitor cells in healthy donors (28). 

Guidelines for the appropriate use of hemopoietic growth factors in children have been proposed by a panel of European experts, who carefully summarized the potential indications and recommendations, and concluded that adult guidelines are apphcable to children in most cases (9). The authors considered that growth factors should be used in children for only a hmited number of circumstances prophylaxis or treatment in low-risk patients treated with chemotherapy, routine use in aplastic anemia, and mobilization of peripheral blood progenitor cells in healthy pediatric donors. 

Stem cell factor amplifies the proliferation and mobilization of myeloid, erythroid, and megakaryocyte colonies when combined with a lineage-specific hemopoietic growth factor (for example G-CSF, IL-3). Stem cell factor, added to other recombinant hemopoietic cytokines, is used to increase the mobilization of peripheral blood progenitor cells. 

Smith TJ, Hillner BE, Schmitz N, et al. Economic analysis of a randomized clinical trial to compare filgrastim-mobilized peripheral blood progenitor cell transplantation with autologous bone marrow transplantation in patients with Hodgkin s and non-Hodgkin s lymphoma. J CUn Oncol 1997 15 5-10. 

Egress of more mature cells from the bone marrow occurs through the endothelial cell barrier. Release of cells such as neutrophils may be stimulated by complement, steroids, or endotoxin. Immature (progenitor) cells that may ultimately become any one of the blood cellular components can be mobilized from the bone marrow into peripheral blood by the administration of a cytotoxic chemotherapy drug (e.g., cyclophosphamide) or a colony-stimulating factor (G-CSE or GM-CSE). This process is commonly referred to as priming the bone marrow for peripheral blood progenitor or stem cell transplantation (see Chap. 134). 

Prior to peripheral blood stem cell harvesting, however, the stem cells must be mobilized or stimulated to enter the peripheral blood. The mobilization process is set into motion by stressing neutrophils and osteoclasts into activity by the use of cytokines with, or without chemotherapy. This results in the shedding and release of membrane-bound stem cell factor (SCF), proliferation of progenitor cells and activation or degradation of various adhesion molecules. Stem cells can be mobilized to enter the peripheral... 

Kawano Y., Kobune M., Chiba H., Nakamura K., Takimoto R., Takada K., Ito Y., Kato J., Hamada H. and Niitsu Y. (2006) Ex vivo expansion of G-CSF-mobilized peripheral blood CD133-I- progenitor cells on coculture with human stromal cells, Exp Hematol 34(2), 150-158. 

Hematologic and coagulation factors Sargramostatin, human recombinant GM-CSF, produced in a yeast (5. cerevisiae) expression system Leukine 19.5,16.8,15.5 (mixture) Mobilization of hematopoietic progenitor cells into peripheral blood... 

Aiuti, A., Webb, I. J., Bleul, C., Springer, T., and Gutierrez-Ramos, J. C. (1997). The chemokine SDF-1 is a chemoattractant for human CD34-I- hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34-I- progenitors to peripheral blood. J. Exp. Med. 185, 111-120. 

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